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• W2022811909 startingPage "e39809" @default.
• W2022811909 abstract "Background Mucus stasis in chronic obstructive pulmonary disease (COPD) is a significant contributor to morbidity and mortality. Potentiators of cystic fibrosis transmembrane conductance regulator (CFTR) activity pharmacologically enhance CFTR function; ivacaftor is one such agent approved to treat CF patients with the G551D-CFTR gating mutation. CFTR potentiators may also be useful for other diseases of mucus stasis, including COPD. Methods and Findings In primary human bronchial epithelial cells, exposure to cigarette smoke extract diminished CFTR-mediated anion transport (65.8±0.2% of control, P<0.005) and mucociliary transport (0.17±0.05 µm/sec vs. 2.4±0.47 µm/sec control, P<0.05) by reducing airway surface liquid depth (7.3±0.6 µm vs. 13.0±0.6 µm control, P<0.005) and augmenting mucus expression (by 64%, P<0.05) without altering transepithelial resistance. Smokers with or without COPD had reduced CFTR activity measured by nasal potential difference compared to age-matched non-smokers (−6.3±1.4 and −8.0±2.0 mV, respectively vs. −15.2±2.7 mV control, each P<0.005, n = 12–14/group); this CFTR decrement was associated with symptoms of chronic bronchitis as measured by the Breathlessness Cough and Sputum Score (r = 0.30, P<0.05) despite controlling for smoking (r = 0.31, P<0.05). Ivacaftor activated CFTR-dependent chloride transport in non-CF epithelia and ameliorated the functional CFTR defect induced by smoke to 185±36% of non-CF control (P<0.05), thereby increasing airway surface liquid (from 7.3±0.6 µm to 10.1±0.4 µm, P<0.005) and mucociliary transport (from 0.27±0.11 µm/s to 2.7±0.28 µm/s, P<0.005). Conclusions Cigarette smoking reduces CFTR activity and is causally related to reduced mucus transport in smokers due to inhibition of CFTR dependent fluid transport. These effects are reversible by the CFTR potentiator ivacaftor, representing a potential therapeutic strategy to augment mucociliary clearance in patients with smoking related lung disease." @default.
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• W2022811909 date "2012-06-29" @default.
• W2022811909 modified "2023-10-16" @default.
• W2022811909 title "A Pharmacologic Approach to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Smoking Related Lung Disease" @default.
• W2022811909 cites W1576360914 @default.
• W2022811909 cites W1966809899 @default.
• W2022811909 cites W1970644262 @default.
• W2022811909 cites W1974884925 @default.
• W2022811909 cites W1980731449 @default.
• W2022811909 cites W1982938776 @default.
• W2022811909 cites W1984653141 @default.
• W2022811909 cites W1988269377 @default.
• W2022811909 cites W2013426880 @default.
• W2022811909 cites W2017483828 @default.
• W2022811909 cites W2031854098 @default.
• W2022811909 cites W2035131077 @default.
• W2022811909 cites W2045325107 @default.
• W2022811909 cites W2045484190 @default.
• W2022811909 cites W2045749557 @default.
• W2022811909 cites W2050548922 @default.
• W2022811909 cites W2075656141 @default.
• W2022811909 cites W2077732883 @default.
• W2022811909 cites W2077799959 @default.
• W2022811909 cites W2080083110 @default.
• W2022811909 cites W2082353409 @default.
• W2022811909 cites W2084643753 @default.
• W2022811909 cites W2096867732 @default.
• W2022811909 cites W2098115046 @default.
• W2022811909 cites W2099627512 @default.
• W2022811909 cites W2100186169 @default.
• W2022811909 cites W2101594367 @default.
• W2022811909 cites W2105062499 @default.
• W2022811909 cites W2105216609 @default.
• W2022811909 cites W2114700246 @default.
• W2022811909 cites W2117975450 @default.
• W2022811909 cites W2121996960 @default.
• W2022811909 cites W2138127281 @default.
• W2022811909 cites W2138471350 @default.
• W2022811909 cites W2140868856 @default.
• W2022811909 cites W2145466675 @default.
• W2022811909 cites W2146729060 @default.
• W2022811909 cites W2149437855 @default.
• W2022811909 cites W2149658463 @default.
• W2022811909 cites W2150168038 @default.
• W2022811909 cites W2152355434 @default.
• W2022811909 cites W2152702795 @default.
• W2022811909 cites W2154841232 @default.
• W2022811909 cites W2159814661 @default.
• W2022811909 cites W2168768310 @default.
• W2022811909 cites W2313829157 @default.
• W2022811909 cites W2330410882 @default.
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• W2022811909 doi "https://doi.org/10.1371/journal.pone.0039809" @default.
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