FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022811924> ?p ?o ?g. }

• W2022811924 endingPage "5365" @default.
• W2022811924 startingPage "5357" @default.
• W2022811924 abstract "Nuclear factor κB (NF-κB), as an antiapoptotic factor, crucially affects the outcomes of cancer treatments, being one of the major culprits of resistance to chemotherapy. In this study, we investigated whether dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-κB inhibitor, can enhance antitumor activities of taxanes in anaplastic thyroid cancer (ATC) cells. Taxanes induced NF-κB activation in ATC cells, which could compromise the therapeutic effect of the drugs. However, DHMEQ, by inhibiting the nuclear translocation of NF-κB, completely suppressed the DNA binding capacities of NF-κB and lowered the levels of nuclear NF-κB protein. Compared with single treatment (either taxane or DHMEQ), the combined treatment strongly potentiated apoptosis, confirmed by cell survival assay; Western blotting for poly (ADP-ribose) polymerase, caspase 3, X-linked inhibitor of apoptosis, and survivin; and flow cytometry for annexin V. Furthermore, we also demonstrate for the first time that the combined treatment showed significantly greater inhibitory effect on tumor growth in a nude mice xenograft model. These findings suggest that taxanes are able to induce NF-κB activation in ATC cells, which could attenuate antitumor activities of the drugs, but inhibition of NF-κB by DHMEQ creates a chemosensitive environment and greatly enhances apoptosis in taxanes-treated ATC cells in vitro and in vivo. Thus, DHMEQ may emerge as an attractive therapeutic strategy to enhance the response to taxanes in ATCs." @default.
• W2022811924 created "2016-06-24" @default.
• W2022811924 creator A5002856322 @default.
• W2022811924 creator A5044470622 @default.
• W2022811924 creator A5052768130 @default.
• W2022811924 creator A5055846880 @default.
• W2022811924 creator A5061184430 @default.
• W2022811924 creator A5066183432 @default.
• W2022811924 creator A5068027963 @default.
• W2022811924 creator A5073622880 @default.
• W2022811924 creator A5084304824 @default.
• W2022811924 creator A5085279080 @default.
• W2022811924 creator A5089614669 @default.
• W2022811924 date "2008-07-24" @default.
• W2022811924 modified "2023-10-16" @default.
• W2022811924 title "Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, Enhances Antitumor Activity of Taxanes in Anaplastic Thyroid Cancer Cells" @default.
• W2022811924 cites W1481925502 @default.
• W2022811924 cites W1554632349 @default.
• W2022811924 cites W1965583590 @default.
• W2022811924 cites W1973568671 @default.
• W2022811924 cites W1976983410 @default.
• W2022811924 cites W1985955648 @default.
• W2022811924 cites W2001333573 @default.
• W2022811924 cites W2008181517 @default.
• W2022811924 cites W2013198592 @default.
• W2022811924 cites W2035364793 @default.
• W2022811924 cites W2050020691 @default.
• W2022811924 cites W2051323297 @default.
• W2022811924 cites W2052471937 @default.
• W2022811924 cites W2058399266 @default.
• W2022811924 cites W2062921699 @default.
• W2022811924 cites W2063539006 @default.
• W2022811924 cites W2066823421 @default.
• W2022811924 cites W2074350704 @default.
• W2022811924 cites W2080616952 @default.
• W2022811924 cites W2084865991 @default.
• W2022811924 cites W2094646101 @default.
• W2022811924 cites W2098169745 @default.
• W2022811924 cites W2108666727 @default.
• W2022811924 cites W2112604698 @default.
• W2022811924 cites W2117529142 @default.
• W2022811924 cites W2118566193 @default.
• W2022811924 cites W2119044641 @default.
• W2022811924 cites W2128939799 @default.
• W2022811924 cites W2133102544 @default.
• W2022811924 cites W2134994441 @default.
• W2022811924 cites W2145338027 @default.
• W2022811924 cites W2147370017 @default.
• W2022811924 cites W2151001214 @default.
• W2022811924 cites W2151837372 @default.
• W2022811924 cites W2156502916 @default.
• W2022811924 cites W2161015285 @default.
• W2022811924 cites W2167789852 @default.
• W2022811924 cites W4292283718 @default.
• W2022811924 cites W4313335080 @default.
• W2022811924 cites W4313343508 @default.
• W2022811924 doi "https://doi.org/10.1210/en.2008-0279" @default.
• W2022811924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18653704" @default.
• W2022811924 hasPublicationYear "2008" @default.
• W2022811924 type Work @default.
• W2022811924 sameAs 2022811924 @default.
• W2022811924 citedByCount "33" @default.
• W2022811924 countsByYear W20228119242012 @default.
• W2022811924 countsByYear W20228119242013 @default.
• W2022811924 countsByYear W20228119242014 @default.
• W2022811924 countsByYear W20228119242015 @default.
• W2022811924 countsByYear W20228119242016 @default.
• W2022811924 countsByYear W20228119242019 @default.
• W2022811924 countsByYear W20228119242020 @default.
• W2022811924 countsByYear W20228119242021 @default.
• W2022811924 countsByYear W20228119242022 @default.
• W2022811924 countsByYear W20228119242023 @default.
• W2022811924 crossrefType "journal-article" @default.
• W2022811924 hasAuthorship W2022811924A5002856322 @default.
• W2022811924 hasAuthorship W2022811924A5044470622 @default.
• W2022811924 hasAuthorship W2022811924A5052768130 @default.
• W2022811924 hasAuthorship W2022811924A5055846880 @default.
• W2022811924 hasAuthorship W2022811924A5061184430 @default.
• W2022811924 hasAuthorship W2022811924A5066183432 @default.
• W2022811924 hasAuthorship W2022811924A5068027963 @default.
• W2022811924 hasAuthorship W2022811924A5073622880 @default.
• W2022811924 hasAuthorship W2022811924A5084304824 @default.
• W2022811924 hasAuthorship W2022811924A5085279080 @default.
• W2022811924 hasAuthorship W2022811924A5089614669 @default.
• W2022811924 hasConcept C121608353 @default.
• W2022811924 hasConcept C126322002 @default.
• W2022811924 hasConcept C150903083 @default.
• W2022811924 hasConcept C153911025 @default.
• W2022811924 hasConcept C185592680 @default.
• W2022811924 hasConcept C190283241 @default.
• W2022811924 hasConcept C207001950 @default.
• W2022811924 hasConcept C2775975398 @default.
• W2022811924 hasConcept C2777408456 @default.
• W2022811924 hasConcept C2779761222 @default.
• W2022811924 hasConcept C2780256643 @default.
• W2022811924 hasConcept C31573885 @default.
• W2022811924 hasConcept C502942594 @default.
• W2022811924 hasConcept C553184892 @default.

• next