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- W2022815027 abstract "Microtubule-associated proteins (MAPs) promote tubulin polymerization, whereas colchicine inhibits this process. In this paper, MAPs have been shown to inhibit colchicine binding to tubulin in a competitive manner. Attempts were made to identify which of the MAPs fraction(s) was responsible; both tau protein (a thermostable molecule with a molecular weight of approximately 70,000) and a high molecular weight fraction (HMW) were able to compete with colchicine. In contrast, Mg2+, which also induces microtubule assembly in vitro, had no effect on colchicine binding to tubulin." @default.
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- W2022815027 title "Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins." @default.
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- W2022815027 doi "https://doi.org/10.1073/pnas.76.1.86" @default.
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