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• W2022819073 abstract "The biological role of quadruplexes and polyamines has been independently associated with cancer. However, quadruplex-polyamine mediated transcriptional regulation remain unaddressed. Herein, using c-MYC quadruplex model, we have attempted to understand quadruplex-polyamine interaction and its role in transcriptional regulation. We initially employed biophysical approach involving CD, UV and FRET to understand the role of polyamines (spermidine and spermine) on conformation, stability, molecular recognition of quadruplex and to investigate the effect of polyamines on quadruplex-Watson Crick duplex transition. Our study demonstrates that polyamines affect the c-MYC quadruplex conformation, perturb its recognition properties and delays duplex formation. The relative free energy difference (DeltaDeltaG degrees) between the duplex and quadruplex structure indicate that polyamines stabilize and favor c-MYC quadruplex over duplex. Further, we investigated the influence of polyamine mediated perturbation of this equilibrium on c-MYC expression. Our results suggest that polyamines induce structural transition of c-MYC quadruplex to a transcriptionally active motif with distinctive molecular recognition property, which drives c-MYC expression. These findings may allow exploiting quadruplex-polyamines interaction for developing antiproliferative strategies to combat aberrant gene expression." @default.
• W2022819073 created "2016-06-24" @default.
• W2022819073 creator A5010098057 @default.
• W2022819073 creator A5022524918 @default.
• W2022819073 creator A5064636651 @default.
• W2022819073 date "2009-03-26" @default.
• W2022819073 modified "2023-10-14" @default.
• W2022819073 title "Elevated polyamines induce c-MYC overexpression by perturbing quadruplex–WC duplex equilibrium" @default.
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• W2022819073 doi "https://doi.org/10.1093/nar/gkp196" @default.
• W2022819073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2691834" @default.
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• W2022819073 hasPublicationYear "2009" @default.
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