FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022821993> ?p ?o ?g. }

• W2022821993 endingPage "1514" @default.
• W2022821993 startingPage "1510" @default.
• W2022821993 abstract "Are the four candidate loci (rs7867029, rs7174015, rs12870438 and rs724078) for human male fertility traits, identified in a genome-wide association study (GWAS) of a Hutterite population in the USA, associated with male infertility in a Japanese population?rs7867029, rs7174015 and rs12870438 are significantly associated with the risk of male infertility in a Japanese population.Recently, a GWAS of a Hutterite population in the USA revealed that 41 single-nucleotide polymorphisms (SNPs) were significantly correlated with family size or birth rate. Of these, four SNPs (rs7867029, rs7174015, rs12870438 and rs724078) were found to be associated with semen parameters in ethnically diverse men from Chicago.This is a case-control association study in a total of 917 Japanese subjects, including 791 fertile men, 76 patients with azoospermia and 50 patients with oligozoospermia.Azoospermia was diagnosed on the basis of semen analysis (the absence of sperm in ejaculate), serum hormone levels and physical examinations. Oligozoospermia was defined as a sperm concentration of <20 × 10(6)/ml. We excluded patients with any known cause of infertility (i.e. obstructive azoospermia, varicocele, cryptorchidism, hypogonadotropic hypogonadism, karyotype abnormalities or complete deletion of AZF a, b or c). The SNPs rs7867029, rs7174015, rs12870438 and rs724078 were genotyped using DNA from peripheral blood samples and either restriction fragment length polymorphism PCR or TaqMan probes. Genetic associations between the four SNPs and male infertility were assessed using a logistic regression analysis under three different comparative models (additive, recessive or dominant).The genotypes of all four SNPs were in Hardy-Weinberg equilibrium in the fertile controls. The SNPs rs7867029 and rs7174015 are associated with oligozoospermia [rs7867029: odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.07-2.68, P = 0.024 (log-additive); rs7174015: OR = 6.52, 95% CI = 1.57-27.10, P = 0.0099 (dominant)] and rs12870438 is associated with azoospermia (OR = 10.90, 95% CI = 2.67-44.60, P = 0.00087 (recessive)] and oligozoospermia [OR = 8.54, 95% CI = 1.52-47.90, P = 0.015 (recessive)]. The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing. There were no associations between rs724078 and azoospermia or oligozoospermia.Even though the sample size of case subjects was not very large, we found that three SNPs were associated with the risk of male infertility in a Japanese population.The three infertility-associated SNPs may be contributing to a quantitative reduction in spermatogenesis.This study was supported in part by the Ministry of Health and Welfare of Japan (1013201) (to T.I.), Grant-in-Aids for Scientific Research (C) (23510242) (to A.Ta.) from the Japan Society for the Promotion of Science, the European Union (BMH4-CT96-0314) (to T. I.) and the Takeda Science Foundation (to A.Ta.). None of the authors has any competing interests to declare." @default.
• W2022821993 created "2016-06-24" @default.
• W2022821993 creator A5004974773 @default.
• W2022821993 creator A5005881937 @default.
• W2022821993 creator A5007237037 @default.
• W2022821993 creator A5012386150 @default.
• W2022821993 creator A5027945250 @default.
• W2022821993 creator A5029317187 @default.
• W2022821993 creator A5034402540 @default.
• W2022821993 creator A5035832784 @default.
• W2022821993 creator A5049331920 @default.
• W2022821993 creator A5052500921 @default.
• W2022821993 creator A5054359199 @default.
• W2022821993 creator A5056021236 @default.
• W2022821993 creator A5063128784 @default.
• W2022821993 creator A5073448109 @default.
• W2022821993 creator A5075803791 @default.
• W2022821993 creator A5081629507 @default.
• W2022821993 date "2015-04-23" @default.
• W2022821993 modified "2023-09-25" @default.
• W2022821993 title "An association study of four candidate loci for human male fertility traits with male infertility" @default.
• W2022821993 cites W189477552 @default.
• W2022821993 cites W1981829031 @default.
• W2022821993 cites W1994871422 @default.
• W2022821993 cites W2002818593 @default.
• W2022821993 cites W2014262519 @default.
• W2022821993 cites W2014805268 @default.
• W2022821993 cites W2024193594 @default.
• W2022821993 cites W2024328683 @default.
• W2022821993 cites W2041087789 @default.
• W2022821993 cites W2041398518 @default.
• W2022821993 cites W2046853623 @default.
• W2022821993 cites W2053222044 @default.
• W2022821993 cites W2064951687 @default.
• W2022821993 cites W2069277865 @default.
• W2022821993 cites W2075020898 @default.
• W2022821993 cites W2079526098 @default.
• W2022821993 cites W2092500318 @default.
• W2022821993 cites W2122822889 @default.
• W2022821993 cites W2128319895 @default.
• W2022821993 cites W2133731514 @default.
• W2022821993 cites W2133797252 @default.
• W2022821993 cites W2137378851 @default.
• W2022821993 cites W2146783046 @default.
• W2022821993 cites W2169580995 @default.
• W2022821993 cites W2321125662 @default.
• W2022821993 cites W2438963268 @default.
• W2022821993 doi "https://doi.org/10.1093/humrep/dev088" @default.
• W2022821993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25908656" @default.
• W2022821993 hasPublicationYear "2015" @default.
• W2022821993 type Work @default.
• W2022821993 sameAs 2022821993 @default.
• W2022821993 citedByCount "27" @default.
• W2022821993 countsByYear W20228219932015 @default.
• W2022821993 countsByYear W20228219932016 @default.
• W2022821993 countsByYear W20228219932017 @default.
• W2022821993 countsByYear W20228219932018 @default.
• W2022821993 countsByYear W20228219932020 @default.
• W2022821993 countsByYear W20228219932021 @default.
• W2022821993 countsByYear W20228219932022 @default.
• W2022821993 countsByYear W20228219932023 @default.
• W2022821993 crossrefType "journal-article" @default.
• W2022821993 hasAuthorship W2022821993A5004974773 @default.
• W2022821993 hasAuthorship W2022821993A5005881937 @default.
• W2022821993 hasAuthorship W2022821993A5007237037 @default.
• W2022821993 hasAuthorship W2022821993A5012386150 @default.
• W2022821993 hasAuthorship W2022821993A5027945250 @default.
• W2022821993 hasAuthorship W2022821993A5029317187 @default.
• W2022821993 hasAuthorship W2022821993A5034402540 @default.
• W2022821993 hasAuthorship W2022821993A5035832784 @default.
• W2022821993 hasAuthorship W2022821993A5049331920 @default.
• W2022821993 hasAuthorship W2022821993A5052500921 @default.
• W2022821993 hasAuthorship W2022821993A5054359199 @default.
• W2022821993 hasAuthorship W2022821993A5056021236 @default.
• W2022821993 hasAuthorship W2022821993A5063128784 @default.
• W2022821993 hasAuthorship W2022821993A5073448109 @default.
• W2022821993 hasAuthorship W2022821993A5075803791 @default.
• W2022821993 hasAuthorship W2022821993A5081629507 @default.
• W2022821993 hasBestOaLocation W20228219931 @default.
• W2022821993 hasConcept C104317684 @default.
• W2022821993 hasConcept C106208931 @default.
• W2022821993 hasConcept C135763542 @default.
• W2022821993 hasConcept C153209595 @default.
• W2022821993 hasConcept C2777338322 @default.
• W2022821993 hasConcept C2777420699 @default.
• W2022821993 hasConcept C2777589648 @default.
• W2022821993 hasConcept C2777688143 @default.
• W2022821993 hasConcept C2778093475 @default.
• W2022821993 hasConcept C2779234561 @default.
• W2022821993 hasConcept C2908647359 @default.
• W2022821993 hasConcept C54355233 @default.
• W2022821993 hasConcept C71924100 @default.
• W2022821993 hasConcept C86803240 @default.
• W2022821993 hasConcept C99454951 @default.
• W2022821993 hasConceptScore W2022821993C104317684 @default.
• W2022821993 hasConceptScore W2022821993C106208931 @default.
• W2022821993 hasConceptScore W2022821993C135763542 @default.
• W2022821993 hasConceptScore W2022821993C153209595 @default.

• next