FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022822585> ?p ?o ?g. }

• W2022822585 endingPage "162" @default.
• W2022822585 startingPage "153" @default.
• W2022822585 abstract "Effects of chronic L-deprenyl administration on hyperactive behaviour and brain monoamine levels were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. SHR were hyperactive, impulsive and had impaired sustained attention when tested with a multiple 2-min fixed interval (FI) 5-min extinction (EXT) schedule of reinforcement. Even low, 0.25 mg/kg, doses of chronically-administered L-deprenyl reduced the impulsiveness (bursts of responses with short interresponse times) of SHR, without altering the general hyperactivity or the impaired sustained attention. The drug had no effect on WKY behaviour. The levels of noradrenaline (NA), dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, measured in neostriatum, nucleus accumbens and frontal cortex, showed that L-deprenyl effectively inhibited monoamine oxidase (MAO) activity. These results suggest that impulsiveness is a behavioural component that may be operating independent of the other components, like hyperactivity and deficient sustained attention, and that can be reduced by chronic MAO-B inhibition with L-deprenyl in this strain of rats. The positive effect of L-deprenyl on impulsiveness is discussed as due either to normalization of an asymmetric dopaminergic activity in the nucleus accumbens, or to a restoration of normal DA function in the prefrontal cortex." @default.
• W2022822585 created "2016-06-24" @default.
• W2022822585 creator A5039869688 @default.
• W2022822585 creator A5048173015 @default.
• W2022822585 creator A5066363929 @default.
• W2022822585 creator A5069367925 @default.
• W2022822585 date "1998-07-01" @default.
• W2022822585 modified "2023-10-18" @default.
• W2022822585 title "Chronic l-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder" @default.
• W2022822585 cites W1840385220 @default.
• W2022822585 cites W1934404972 @default.
• W2022822585 cites W1969280290 @default.
• W2022822585 cites W1976456194 @default.
• W2022822585 cites W1983106271 @default.
• W2022822585 cites W1986671246 @default.
• W2022822585 cites W1991471569 @default.
• W2022822585 cites W1994806628 @default.
• W2022822585 cites W2000571453 @default.
• W2022822585 cites W2007497289 @default.
• W2022822585 cites W2007766526 @default.
• W2022822585 cites W2008388316 @default.
• W2022822585 cites W2010928169 @default.
• W2022822585 cites W2013167152 @default.
• W2022822585 cites W2019492962 @default.
• W2022822585 cites W2030432141 @default.
• W2022822585 cites W2031536221 @default.
• W2022822585 cites W2035523609 @default.
• W2022822585 cites W2050499198 @default.
• W2022822585 cites W2052236435 @default.
• W2022822585 cites W2055702550 @default.
• W2022822585 cites W2066249560 @default.
• W2022822585 cites W2067683471 @default.
• W2022822585 cites W2073505373 @default.
• W2022822585 cites W2074521517 @default.
• W2022822585 cites W2080714711 @default.
• W2022822585 cites W2095434227 @default.
• W2022822585 cites W2104685833 @default.
• W2022822585 cites W2111012319 @default.
• W2022822585 cites W2113002353 @default.
• W2022822585 cites W2113082650 @default.
• W2022822585 cites W2117771667 @default.
• W2022822585 cites W2169246339 @default.
• W2022822585 cites W4301698877 @default.
• W2022822585 doi "https://doi.org/10.1016/s0166-4328(97)00176-9" @default.
• W2022822585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9708846" @default.
• W2022822585 hasPublicationYear "1998" @default.
• W2022822585 type Work @default.
• W2022822585 sameAs 2022822585 @default.
• W2022822585 citedByCount "56" @default.
• W2022822585 countsByYear W20228225852012 @default.
• W2022822585 countsByYear W20228225852013 @default.
• W2022822585 countsByYear W20228225852014 @default.
• W2022822585 countsByYear W20228225852017 @default.
• W2022822585 countsByYear W20228225852019 @default.
• W2022822585 countsByYear W20228225852020 @default.
• W2022822585 crossrefType "journal-article" @default.
• W2022822585 hasAuthorship W2022822585A5039869688 @default.
• W2022822585 hasAuthorship W2022822585A5048173015 @default.
• W2022822585 hasAuthorship W2022822585A5066363929 @default.
• W2022822585 hasAuthorship W2022822585A5069367925 @default.
• W2022822585 hasConcept C126322002 @default.
• W2022822585 hasConcept C134018914 @default.
• W2022822585 hasConcept C137183658 @default.
• W2022822585 hasConcept C15744967 @default.
• W2022822585 hasConcept C169760540 @default.
• W2022822585 hasConcept C169900460 @default.
• W2022822585 hasConcept C170493617 @default.
• W2022822585 hasConcept C181199279 @default.
• W2022822585 hasConcept C185592680 @default.
• W2022822585 hasConcept C187714386 @default.
• W2022822585 hasConcept C2775864247 @default.
• W2022822585 hasConcept C2775894120 @default.
• W2022822585 hasConcept C2776024655 @default.
• W2022822585 hasConcept C2776134090 @default.
• W2022822585 hasConcept C2776552330 @default.
• W2022822585 hasConcept C2779134260 @default.
• W2022822585 hasConcept C2779734285 @default.
• W2022822585 hasConcept C2781195155 @default.
• W2022822585 hasConcept C513476851 @default.
• W2022822585 hasConcept C55493867 @default.
• W2022822585 hasConcept C71924100 @default.
• W2022822585 hasConceptScore W2022822585C126322002 @default.
• W2022822585 hasConceptScore W2022822585C134018914 @default.
• W2022822585 hasConceptScore W2022822585C137183658 @default.
• W2022822585 hasConceptScore W2022822585C15744967 @default.
• W2022822585 hasConceptScore W2022822585C169760540 @default.
• W2022822585 hasConceptScore W2022822585C169900460 @default.
• W2022822585 hasConceptScore W2022822585C170493617 @default.
• W2022822585 hasConceptScore W2022822585C181199279 @default.
• W2022822585 hasConceptScore W2022822585C185592680 @default.
• W2022822585 hasConceptScore W2022822585C187714386 @default.
• W2022822585 hasConceptScore W2022822585C2775864247 @default.
• W2022822585 hasConceptScore W2022822585C2775894120 @default.
• W2022822585 hasConceptScore W2022822585C2776024655 @default.
• W2022822585 hasConceptScore W2022822585C2776134090 @default.
• W2022822585 hasConceptScore W2022822585C2776552330 @default.
• W2022822585 hasConceptScore W2022822585C2779134260 @default.
• W2022822585 hasConceptScore W2022822585C2779734285 @default.

• next