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- W2022822771 abstract "Human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes for the Tax protein, which has a transforming capacity in vitro. Tax contains at its C-terminus a binding motif for PDZ domain-containing proteins (PSD95-DLG1-ZO1). It has been shown that the C-terminal motif of Tax is involved in Tax oncogenic capacity. Ten different PDZ domain-containing proteins have been reported to interact with Tax, but the specificity of Tax-human PDZome interactions has not been investigated. The objective of this study is to obtain a comprehensive interactome map for Tax and the human PDZome and to determine a global role of Tax-PDZ interactions in HTLV-1 biology. By using different protein-protein interaction methods we have generated a Tax/human PDZome interaction map. We then performed a clustering analysis to define biological functions associated with Tax/PDZ interactions. PDZ Proteins involved in cell shape, cytoskeleton organization and membrane polarization and traffic were overrepresented, and suggest that Tax/PDZ interactions may be involved in Tax-mediated stimulation of T cell activation pathways." @default.
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- W2022822771 date "2014-01-01" @default.
- W2022822771 modified "2023-09-26" @default.
- W2022822771 title "An interaction map for HTLV-1 Tax and PDZ-containing proteins" @default.
- W2022822771 doi "https://doi.org/10.1186/1742-4690-11-s1-p101" @default.
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