FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022824575> ?p ?o ?g. }

• W2022824575 endingPage "603" @default.
• W2022824575 startingPage "594" @default.
• W2022824575 abstract "Several studies have demonstrated a consistent increase in the CD8+ T-cell subset of pigs following infection with porcine reproductive and respiratory virus (PRRSV). Consequently, it has been suggested that CD8+ T-cells may play an important role in protection against this infection. In order to test this hypothesis, we examined five 5-week-old pigs, which had been depleted for CD8+ T-cells by treatment with anti-CD8 mAb injections, starting 2 days before inoculation with PRRSV. Virus-inoculated and sham-inoculated age-matched pigs served as controls. Blood samples were collected continuously, together with organ material at necropsy, to study kinetics of leukocyte subpopulations, antibody production and virus persistence in individual pigs. Significant lower CD8+ T-cell counts on day 0, that is, before virus challenge, in the anti-CD8 mAb treated pigs compared to the control pigs, confirmed the depletion effect of specific mAb therapy. Almost complete depletion of cell subsets expressing the CD8+ antigen was obtained on day 2 and 5 post infection (PI) with nadir less than 1% of peripheral blood mononuclear cells (PBMC). One week PI, an increase in T-cell subsets was observed for both anti-CD8 mAb treated pigs and virus-inoculated control pigs. T-memory cells and cytotoxic T-cells reached levels comparative with the virus-inoculated control pigs on days 8 and 12 PI, respectively, whereas NKcells remained suppressed for the rest of the experimental period. An extraordinary increase of T-helper cells in the anti-CD8 mAb treated pigs with a significantly higher level than in the virus-inoculated and sham-inoculated control pigs, was observed from day 12 PI. In conclusion, it was established that CD8+ T-cell depletion in the early phase of PRRSV infection neither caused increased disease nor influenced the ability to clear virus in the treated pigs." @default.
• W2022824575 created "2016-06-24" @default.
• W2022824575 creator A5008916053 @default.
• W2022824575 creator A5037617983 @default.
• W2022824575 creator A5038883321 @default.
• W2022824575 date "2004-12-01" @default.
• W2022824575 modified "2023-10-05" @default.
• W2022824575 title "Temporary CD8⁺T-Cell Depletion in Pigs Does Not Exacerbate Infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)" @default.
• W2022824575 cites W1625897096 @default.
• W2022824575 cites W1963943639 @default.
• W2022824575 cites W1977563342 @default.
• W2022824575 cites W1982039078 @default.
• W2022824575 cites W1984594080 @default.
• W2022824575 cites W1987499490 @default.
• W2022824575 cites W1990350083 @default.
• W2022824575 cites W1990890248 @default.
• W2022824575 cites W1991504179 @default.
• W2022824575 cites W1996355868 @default.
• W2022824575 cites W1996799820 @default.
• W2022824575 cites W1999385941 @default.
• W2022824575 cites W2019099694 @default.
• W2022824575 cites W2027045581 @default.
• W2022824575 cites W2030522563 @default.
• W2022824575 cites W2034259915 @default.
• W2022824575 cites W2041498251 @default.
• W2022824575 cites W2050007720 @default.
• W2022824575 cites W2074979811 @default.
• W2022824575 cites W2081758923 @default.
• W2022824575 cites W2091009744 @default.
• W2022824575 cites W2102272195 @default.
• W2022824575 cites W2116523016 @default.
• W2022824575 cites W2122732465 @default.
• W2022824575 cites W2129620275 @default.
• W2022824575 cites W2140296277 @default.
• W2022824575 cites W2157227966 @default.
• W2022824575 doi "https://doi.org/10.1089/vim.2004.17.594" @default.
• W2022824575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15671757" @default.
• W2022824575 hasPublicationYear "2004" @default.
• W2022824575 type Work @default.
• W2022824575 sameAs 2022824575 @default.
• W2022824575 citedByCount "33" @default.
• W2022824575 countsByYear W20228245752012 @default.
• W2022824575 countsByYear W20228245752013 @default.
• W2022824575 countsByYear W20228245752015 @default.
• W2022824575 countsByYear W20228245752016 @default.
• W2022824575 countsByYear W20228245752017 @default.
• W2022824575 countsByYear W20228245752018 @default.
• W2022824575 countsByYear W20228245752021 @default.
• W2022824575 countsByYear W20228245752022 @default.
• W2022824575 countsByYear W20228245752023 @default.
• W2022824575 crossrefType "journal-article" @default.
• W2022824575 hasAuthorship W2022824575A5008916053 @default.
• W2022824575 hasAuthorship W2022824575A5037617983 @default.
• W2022824575 hasAuthorship W2022824575A5038883321 @default.
• W2022824575 hasConcept C105702510 @default.
• W2022824575 hasConcept C137061746 @default.
• W2022824575 hasConcept C154317977 @default.
• W2022824575 hasConcept C159047783 @default.
• W2022824575 hasConcept C159654299 @default.
• W2022824575 hasConcept C16685009 @default.
• W2022824575 hasConcept C167672396 @default.
• W2022824575 hasConcept C202751555 @default.
• W2022824575 hasConcept C203014093 @default.
• W2022824575 hasConcept C2522874641 @default.
• W2022824575 hasConcept C2776090121 @default.
• W2022824575 hasConcept C2779819720 @default.
• W2022824575 hasConcept C534529494 @default.
• W2022824575 hasConcept C542903549 @default.
• W2022824575 hasConcept C55493867 @default.
• W2022824575 hasConcept C71924100 @default.
• W2022824575 hasConcept C86803240 @default.
• W2022824575 hasConcept C8891405 @default.
• W2022824575 hasConceptScore W2022824575C105702510 @default.
• W2022824575 hasConceptScore W2022824575C137061746 @default.
• W2022824575 hasConceptScore W2022824575C154317977 @default.
• W2022824575 hasConceptScore W2022824575C159047783 @default.
• W2022824575 hasConceptScore W2022824575C159654299 @default.
• W2022824575 hasConceptScore W2022824575C16685009 @default.
• W2022824575 hasConceptScore W2022824575C167672396 @default.
• W2022824575 hasConceptScore W2022824575C202751555 @default.
• W2022824575 hasConceptScore W2022824575C203014093 @default.
• W2022824575 hasConceptScore W2022824575C2522874641 @default.
• W2022824575 hasConceptScore W2022824575C2776090121 @default.
• W2022824575 hasConceptScore W2022824575C2779819720 @default.
• W2022824575 hasConceptScore W2022824575C534529494 @default.
• W2022824575 hasConceptScore W2022824575C542903549 @default.
• W2022824575 hasConceptScore W2022824575C55493867 @default.
• W2022824575 hasConceptScore W2022824575C71924100 @default.
• W2022824575 hasConceptScore W2022824575C86803240 @default.
• W2022824575 hasConceptScore W2022824575C8891405 @default.
• W2022824575 hasIssue "4" @default.
• W2022824575 hasLocation W20228245751 @default.
• W2022824575 hasLocation W20228245752 @default.
• W2022824575 hasOpenAccess W2022824575 @default.
• W2022824575 hasPrimaryLocation W20228245751 @default.
• W2022824575 hasRelatedWork W1980763727 @default.
• W2022824575 hasRelatedWork W1991811352 @default.
• W2022824575 hasRelatedWork W206556109 @default.

• next