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- W2022825094 abstract "Summary The generation of large amounts of induced CD4 + CD25 + Foxp3 + regulatory T (iTreg) cells is of great interest for several immunotherapy applications, therefore a better understanding of signals controlling iTreg cell differentiation and expansion is required. There is evidence that oxidative metabolism may regulate several key signalling pathways in T cells. This prompted us to investigate the effects of oxygenation on iTreg cell generation by comparing the effects of atmospheric (21%) or of low (5%) O 2 concentrations on the phenotype of bead‐stimulated murine splenic CD4 + T cells from Foxp3‐KI‐GFP T‐cell receptor transgenic mice. The production of intracellular reactive oxygen species was shown to play a major role in the generation of iTreg cells, a process characterized by increased levels of Sirt1, PTEN and Glut1 on the committed cells, independently of the level of oxygenation. The suppressive function of iTreg cells generated either in atmospheric or low oxygen levels was equivalent. However, greater yields of iTreg cells were obtained under low oxygenation, resulting from a higher proliferative rate of the committed Treg cells and higher levels of Foxp3, suggesting a better stability of the differentiation process. Higher expression of Glut1 detected on iTreg cells generated under hypoxic culture conditions provides a likely explanation for the enhanced proliferation of these cells as compared to those cultured under ambient oxygen. Such results have important implications for understanding Treg cell homeostasis and developing in vitro protocols for the generation of Treg cells from naive T lymphocytes." @default.
- W2022825094 created "2016-06-24" @default.
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- W2022825094 date "2015-02-13" @default.
- W2022825094 modified "2023-10-16" @default.
- W2022825094 title "Hypoxic culture conditions enhance the generation of regulatory T cells" @default.
- W2022825094 cites W1502206782 @default.
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- W2022825094 cites W1944753949 @default.
- W2022825094 cites W1967590823 @default.
- W2022825094 cites W1970602197 @default.
- W2022825094 cites W1970662865 @default.
- W2022825094 cites W1970763537 @default.
- W2022825094 cites W1971202292 @default.
- W2022825094 cites W1973393458 @default.
- W2022825094 cites W1982461497 @default.
- W2022825094 cites W1986158733 @default.
- W2022825094 cites W1986391308 @default.
- W2022825094 cites W1986925527 @default.
- W2022825094 cites W1991263620 @default.
- W2022825094 cites W1992250154 @default.
- W2022825094 cites W1992949662 @default.
- W2022825094 cites W1995858393 @default.
- W2022825094 cites W1999875730 @default.
- W2022825094 cites W2005299533 @default.
- W2022825094 cites W2011653139 @default.
- W2022825094 cites W2016496152 @default.
- W2022825094 cites W2019918813 @default.
- W2022825094 cites W2022970298 @default.
- W2022825094 cites W2027562106 @default.
- W2022825094 cites W2031959283 @default.
- W2022825094 cites W2036755369 @default.
- W2022825094 cites W2041079472 @default.
- W2022825094 cites W2043237487 @default.
- W2022825094 cites W2055563043 @default.
- W2022825094 cites W2056721231 @default.
- W2022825094 cites W2057635215 @default.
- W2022825094 cites W2061037963 @default.
- W2022825094 cites W2064228332 @default.
- W2022825094 cites W2072954179 @default.
- W2022825094 cites W2073526321 @default.
- W2022825094 cites W2075391300 @default.
- W2022825094 cites W2086485066 @default.
- W2022825094 cites W2089251600 @default.
- W2022825094 cites W2089887386 @default.
- W2022825094 cites W2089916504 @default.
- W2022825094 cites W2091041420 @default.
- W2022825094 cites W2093969306 @default.
- W2022825094 cites W2094807579 @default.
- W2022825094 cites W2097478351 @default.
- W2022825094 cites W2102619095 @default.
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- W2022825094 cites W2127123481 @default.
- W2022825094 cites W2131234404 @default.
- W2022825094 cites W2134053452 @default.
- W2022825094 cites W2139595663 @default.
- W2022825094 cites W2140999266 @default.
- W2022825094 cites W2142491530 @default.
- W2022825094 cites W2145353379 @default.
- W2022825094 cites W2145487507 @default.
- W2022825094 cites W2146409195 @default.
- W2022825094 cites W2157739158 @default.
- W2022825094 cites W2160458616 @default.
- W2022825094 cites W2162873738 @default.
- W2022825094 cites W2168244648 @default.
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- W2022825094 doi "https://doi.org/10.1111/imm.12388" @default.
- W2022825094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4557680" @default.
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