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- W2022831739 abstract "Current work demonstrates a new method and a new device for simultaneous in vivo measurements of sarcomere imaging and fiber tension. Sarcomere, a building block of muscles, plays a critical role in muscle contraction. In the pathological conditions, the biomechanical properties of sarcomere and muscle fibers may be altered significantly. We developed a novel methodology by combining the optical image capture system with force measurement which allowed us to investigate the muscle cell properties in vivo under monitored/controlled tension. The methodology was validated in an in vivo rat model as well as using an in vitro corroboration setup. The in vivo evaluation provides us a powerful tool to investigate pathological changes of fibers/sarcomeres and help determine proper treatment." @default.
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- W2022831739 date "2010-08-01" @default.
- W2022831739 modified "2023-10-16" @default.
- W2022831739 title "In vivo sarcomere imaging and fiber tension measurements" @default.
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- W2022831739 doi "https://doi.org/10.1109/iembs.2010.5627513" @default.
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