FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022832318> ?p ?o ?g. }

• W2022832318 endingPage "1075" @default.
• W2022832318 startingPage "1067" @default.
• W2022832318 abstract "Objective. To investigate the possible use of a 13C-uracil breath test for gastric emptying by evaluating the pharmacokinetic properties of 13C-uracil in a breath test in rats, in comparison with 13C-acetate and 13C-octanoate, traditional 13C-probes for gastric emptying. Material and methods. Absorption of the 13C-probes from different parts of the gastrointestinal tract was evaluated in fasted rats. 13C-Uracil breath tests for gastric emptying were carried out in conditions where delayed gastric emptying was induced by clonidine, quinpirole, and propantheline, and in a postoperative ileus model. Following oral administration, we measured residual 13C-uracil in the stomach and correlated the amount with the breath response. Results. All the 13C-probes employed were well absorbed from the intestine after intraduodenal administration. After intragastric administration, 13C-uracil was not absorbed from the stomach, but 13C-acetate and 13C-octanoate were partly absorbed from the stomach. The cumulative 14C-uracil recovery (%) at 168 h was 92.3, 6.3, or 0.5%, from expired gases, urine, and feces, respectively. Δ13C values in 13C-uracil breath tests were decreased in conditions characterized by delayed gastric emptying. A highly negative correlation was observed between the breath response and the residual ratio of 13C-uracil in the stomach after oral administration of 13C-uracil, indicating that 13C-uracil can be used as an in vivo probe for evaluating gastric emptying in a quantitative manner. Conclusions. This study showed that 13C-uracil has desirable pharmacokinetic properties as an in vivo probe of gastric emptying. It is thus suggested that the 13C-uracil breath test may be useful for the measurement of gastric emptying in humans." @default.
• W2022832318 created "2016-06-24" @default.
• W2022832318 creator A5003112439 @default.
• W2022832318 creator A5003520045 @default.
• W2022832318 creator A5019755982 @default.
• W2022832318 creator A5061205667 @default.
• W2022832318 creator A5062613488 @default.
• W2022832318 creator A5068652349 @default.
• W2022832318 creator A5074938137 @default.
• W2022832318 creator A5078775334 @default.
• W2022832318 date "2009-01-01" @default.
• W2022832318 modified "2023-09-25" @default.
• W2022832318 title "Desirable pharmacokinetic properties of13C-uracil as a breath test probe of gastric emptying in comparison with13C-acetate and13C-octanoate in rats" @default.
• W2022832318 cites W1504216369 @default.
• W2022832318 cites W1977718007 @default.
• W2022832318 cites W1981975007 @default.
• W2022832318 cites W1986121938 @default.
• W2022832318 cites W1987190553 @default.
• W2022832318 cites W1990624775 @default.
• W2022832318 cites W1994032248 @default.
• W2022832318 cites W1995642681 @default.
• W2022832318 cites W2003493928 @default.
• W2022832318 cites W2003701051 @default.
• W2022832318 cites W2010569836 @default.
• W2022832318 cites W2043327262 @default.
• W2022832318 cites W2045414654 @default.
• W2022832318 cites W2046907939 @default.
• W2022832318 cites W2053573574 @default.
• W2022832318 cites W2053688735 @default.
• W2022832318 cites W2067355591 @default.
• W2022832318 cites W2070442518 @default.
• W2022832318 cites W2078658164 @default.
• W2022832318 cites W2097477058 @default.
• W2022832318 cites W2110589976 @default.
• W2022832318 cites W2157103773 @default.
• W2022832318 cites W2409431705 @default.
• W2022832318 doi "https://doi.org/10.1080/00365520903114904" @default.
• W2022832318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19585373" @default.
• W2022832318 hasPublicationYear "2009" @default.
• W2022832318 type Work @default.
• W2022832318 sameAs 2022832318 @default.
• W2022832318 citedByCount "3" @default.
• W2022832318 countsByYear W20228323182013 @default.
• W2022832318 countsByYear W20228323182020 @default.
• W2022832318 crossrefType "journal-article" @default.
• W2022832318 hasAuthorship W2022832318A5003112439 @default.
• W2022832318 hasAuthorship W2022832318A5003520045 @default.
• W2022832318 hasAuthorship W2022832318A5019755982 @default.
• W2022832318 hasAuthorship W2022832318A5061205667 @default.
• W2022832318 hasAuthorship W2022832318A5062613488 @default.
• W2022832318 hasAuthorship W2022832318A5068652349 @default.
• W2022832318 hasAuthorship W2022832318A5074938137 @default.
• W2022832318 hasAuthorship W2022832318A5078775334 @default.
• W2022832318 hasConcept C112705442 @default.
• W2022832318 hasConcept C126322002 @default.
• W2022832318 hasConcept C185592680 @default.
• W2022832318 hasConcept C2775981797 @default.
• W2022832318 hasConcept C2776409635 @default.
• W2022832318 hasConcept C2779422922 @default.
• W2022832318 hasConcept C2779554091 @default.
• W2022832318 hasConcept C3020479747 @default.
• W2022832318 hasConcept C552990157 @default.
• W2022832318 hasConcept C55493867 @default.
• W2022832318 hasConcept C71924100 @default.
• W2022832318 hasConcept C90924648 @default.
• W2022832318 hasConcept C98274493 @default.
• W2022832318 hasConceptScore W2022832318C112705442 @default.
• W2022832318 hasConceptScore W2022832318C126322002 @default.
• W2022832318 hasConceptScore W2022832318C185592680 @default.
• W2022832318 hasConceptScore W2022832318C2775981797 @default.
• W2022832318 hasConceptScore W2022832318C2776409635 @default.
• W2022832318 hasConceptScore W2022832318C2779422922 @default.
• W2022832318 hasConceptScore W2022832318C2779554091 @default.
• W2022832318 hasConceptScore W2022832318C3020479747 @default.
• W2022832318 hasConceptScore W2022832318C552990157 @default.
• W2022832318 hasConceptScore W2022832318C55493867 @default.
• W2022832318 hasConceptScore W2022832318C71924100 @default.
• W2022832318 hasConceptScore W2022832318C90924648 @default.
• W2022832318 hasConceptScore W2022832318C98274493 @default.
• W2022832318 hasIssue "9" @default.
• W2022832318 hasLocation W20228323181 @default.
• W2022832318 hasLocation W20228323182 @default.
• W2022832318 hasOpenAccess W2022832318 @default.
• W2022832318 hasPrimaryLocation W20228323181 @default.
• W2022832318 hasRelatedWork W1996598762 @default.
• W2022832318 hasRelatedWork W2022832318 @default.
• W2022832318 hasRelatedWork W2046734356 @default.
• W2022832318 hasRelatedWork W2058055726 @default.
• W2022832318 hasRelatedWork W2097707093 @default.
• W2022832318 hasRelatedWork W2398085940 @default.
• W2022832318 hasRelatedWork W2410112927 @default.
• W2022832318 hasRelatedWork W2913794110 @default.
• W2022832318 hasRelatedWork W373906784 @default.
• W2022832318 hasRelatedWork W1965026317 @default.
• W2022832318 hasVolume "44" @default.
• W2022832318 isParatext "false" @default.
• W2022832318 isRetracted "false" @default.
• W2022832318 magId "2022832318" @default.

• next