FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022833813> ?p ?o ?g. }

• W2022833813 endingPage "387" @default.
• W2022833813 startingPage "382" @default.
• W2022833813 abstract "Interferon alpha (IFN-α) is used to treat chronic myelogenous leukaemia (CML) patients. However, its target(s) remain(s) unknown. One possibility is that there is a differing sensitivity of the leukaemic from the normal colony-forming cell (CFC) compartments to IFN-α. Co-cultures of progenitors with stromal cells provide a valuable tool to dissect direct and indirect activities of IFN-α. In this study, we have used endothelial cells (EC) as a source of stromal cells. In co-cultures of normal progenitors with EC, IFN-α increased the generation of clonogenic cells, mainly via an increased production of flt3 ligand (FL) by EC. In contrast, in co-cultures of CML progenitors with EC, IFN-α inhibited the generation of clonogenic cells, mainly by direct inhibition on the progenitors, the up-regulation of FL production by stromal cells being unable to compensate for the direct inhibitory effects of IFN-α. These data provide evidence for a differential effect of IFN-α on the growth of CML and normal CFC cells in a stromal context and suggest that an alteration in the response of CML progenitor cells to FL is important in the explanation of this differential effect." @default.
• W2022833813 created "2016-06-24" @default.
• W2022833813 creator A5003035983 @default.
• W2022833813 creator A5005668617 @default.
• W2022833813 creator A5011977231 @default.
• W2022833813 creator A5027632806 @default.
• W2022833813 creator A5031019986 @default.
• W2022833813 creator A5040244002 @default.
• W2022833813 creator A5058334809 @default.
• W2022833813 creator A5065431453 @default.
• W2022833813 creator A5069199319 @default.
• W2022833813 date "2000-05-01" @default.
• W2022833813 modified "2023-10-14" @default.
• W2022833813 title "Differential effect of interferon α on chronic myelogenous leukaemia and normal haematopoietic progenitors in a stromal cell co-culture context: role of the flt3 ligand" @default.
• W2022833813 cites W1498708301 @default.
• W2022833813 cites W1580139946 @default.
• W2022833813 cites W1955659593 @default.
• W2022833813 cites W1965180167 @default.
• W2022833813 cites W1978329599 @default.
• W2022833813 cites W1983075214 @default.
• W2022833813 cites W1985357637 @default.
• W2022833813 cites W1986065754 @default.
• W2022833813 cites W1991171923 @default.
• W2022833813 cites W1996699752 @default.
• W2022833813 cites W2012753775 @default.
• W2022833813 cites W2029602430 @default.
• W2022833813 cites W2032235066 @default.
• W2022833813 cites W2036733303 @default.
• W2022833813 cites W2037045407 @default.
• W2022833813 cites W2055352087 @default.
• W2022833813 cites W2057878394 @default.
• W2022833813 cites W2060892787 @default.
• W2022833813 cites W2081698415 @default.
• W2022833813 cites W2085397716 @default.
• W2022833813 cites W2128330870 @default.
• W2022833813 cites W2137661796 @default.
• W2022833813 cites W214380766 @default.
• W2022833813 cites W2157603347 @default.
• W2022833813 cites W2168199449 @default.
• W2022833813 cites W2171575942 @default.
• W2022833813 cites W2262683914 @default.
• W2022833813 cites W2272909078 @default.
• W2022833813 cites W2289173177 @default.
• W2022833813 cites W2301107877 @default.
• W2022833813 cites W2323252391 @default.
• W2022833813 cites W2324692248 @default.
• W2022833813 cites W232742645 @default.
• W2022833813 cites W2337277825 @default.
• W2022833813 cites W2343499784 @default.
• W2022833813 doi "https://doi.org/10.1046/j.1365-2141.2000.01917.x" @default.
• W2022833813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10848829" @default.
• W2022833813 hasPublicationYear "2000" @default.
• W2022833813 type Work @default.
• W2022833813 sameAs 2022833813 @default.
• W2022833813 citedByCount "5" @default.
• W2022833813 countsByYear W20228338132014 @default.
• W2022833813 crossrefType "journal-article" @default.
• W2022833813 hasAuthorship W2022833813A5003035983 @default.
• W2022833813 hasAuthorship W2022833813A5005668617 @default.
• W2022833813 hasAuthorship W2022833813A5011977231 @default.
• W2022833813 hasAuthorship W2022833813A5027632806 @default.
• W2022833813 hasAuthorship W2022833813A5031019986 @default.
• W2022833813 hasAuthorship W2022833813A5040244002 @default.
• W2022833813 hasAuthorship W2022833813A5058334809 @default.
• W2022833813 hasAuthorship W2022833813A5065431453 @default.
• W2022833813 hasAuthorship W2022833813A5069199319 @default.
• W2022833813 hasBestOaLocation W20228338131 @default.
• W2022833813 hasConcept C109159458 @default.
• W2022833813 hasConcept C117262875 @default.
• W2022833813 hasConcept C151730666 @default.
• W2022833813 hasConcept C16930146 @default.
• W2022833813 hasConcept C201750760 @default.
• W2022833813 hasConcept C203014093 @default.
• W2022833813 hasConcept C2776178377 @default.
• W2022833813 hasConcept C2776960273 @default.
• W2022833813 hasConcept C2778461978 @default.
• W2022833813 hasConcept C2779343474 @default.
• W2022833813 hasConcept C28328180 @default.
• W2022833813 hasConcept C502942594 @default.
• W2022833813 hasConcept C54355233 @default.
• W2022833813 hasConcept C81885089 @default.
• W2022833813 hasConcept C86803240 @default.
• W2022833813 hasConcept C95444343 @default.
• W2022833813 hasConceptScore W2022833813C109159458 @default.
• W2022833813 hasConceptScore W2022833813C117262875 @default.
• W2022833813 hasConceptScore W2022833813C151730666 @default.
• W2022833813 hasConceptScore W2022833813C16930146 @default.
• W2022833813 hasConceptScore W2022833813C201750760 @default.
• W2022833813 hasConceptScore W2022833813C203014093 @default.
• W2022833813 hasConceptScore W2022833813C2776178377 @default.
• W2022833813 hasConceptScore W2022833813C2776960273 @default.
• W2022833813 hasConceptScore W2022833813C2778461978 @default.
• W2022833813 hasConceptScore W2022833813C2779343474 @default.
• W2022833813 hasConceptScore W2022833813C28328180 @default.
• W2022833813 hasConceptScore W2022833813C502942594 @default.
• W2022833813 hasConceptScore W2022833813C54355233 @default.
• W2022833813 hasConceptScore W2022833813C81885089 @default.
• W2022833813 hasConceptScore W2022833813C86803240 @default.

• next