FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022834873> ?p ?o ?g. }

• W2022834873 endingPage "158" @default.
• W2022834873 startingPage "153" @default.
• W2022834873 abstract "Four consecutive patients with alcoholic cirrhosis and hepatorenal syndrome were treated with misoprostol, a synthetic methylester prostaglandin E1 analogue at twice the dosage advocated for anti-ulcer therapy (i.e., 0.4 mg four times per day orally) and albumin infusions. The mean urinary output obtained over the 3 days preceding misoprostol administration was 250, 315, 550 and 195 ml per 24 h, respectively, in the four patients, despite adequate volume expansion by plasma albumin to reach normal or high central venous pressure. Diuresis increased to 1450, 2440, 925 and 1300 ml, respectively, on days 2–4 after onset of therapy. Serum creatinine levels were 71, 51, 33 and 35 mg/l before and dropped to 26, 21, 13 and 17 mg/l during treatment. All patients had hyponatraemia (117–128 mequiv/l) which normalized, although they were continued on a low sodium intake of less than 10 mequiv per 24 h. Urinary sodium excretion increased from 0.4-3 mmol per 24 h, to 15–40 in the first two cases and only slightly to 3–5 in the last two patients. Three patients died after 10, 30 and 40 days due to oesophageal bleeding, encephalopathy or pulmonary infection, whereas one patient underwent an orthotopic liver transplantation when her serum creatinine attained a level of 13 mg/l. In the first patient, hepatorenal syndrome recurred 10 days after stopping the misoprostol treatment. High doses of misoprostol in the presence of adequate volume expansion thus seem to produce marked diuresis and creatininuria as well as mild natriuresis. It constitutes an acceptable treatment which will temporarily improve the kidney function in the hepatorenal syndrome. The mechanism is unclear; prostaglandin E1 (PGE1) could counteract circulating vasoconstrictor agents, thus restoring indirectly the kidney circulation or it could act at the liver level and counteract a hypothetically hormonal substance released by diseased liver cells." @default.
• W2022834873 created "2016-06-24" @default.
• W2022834873 creator A5036810251 @default.
• W2022834873 creator A5068910750 @default.
• W2022834873 creator A5079075767 @default.
• W2022834873 creator A5080844718 @default.
• W2022834873 creator A5088236321 @default.
• W2022834873 creator A5090645179 @default.
• W2022834873 date "1990-09-01" @default.
• W2022834873 modified "2023-10-16" @default.
• W2022834873 title "Reversal of hepatorenal syndrome in four patients by peroral misoprostol (prostaglandin E1 analogue) and albumin administration" @default.
• W2022834873 cites W1483437251 @default.
• W2022834873 cites W1514495514 @default.
• W2022834873 cites W1547710474 @default.
• W2022834873 cites W1552268612 @default.
• W2022834873 cites W1564556829 @default.
• W2022834873 cites W1649143309 @default.
• W2022834873 cites W1979651804 @default.
• W2022834873 cites W1981972230 @default.
• W2022834873 cites W1993812341 @default.
• W2022834873 cites W2000348380 @default.
• W2022834873 cites W2029995728 @default.
• W2022834873 cites W2036487592 @default.
• W2022834873 cites W2038927390 @default.
• W2022834873 cites W2040553060 @default.
• W2022834873 cites W2042816070 @default.
• W2022834873 cites W2053548152 @default.
• W2022834873 cites W2054641887 @default.
• W2022834873 cites W2068305029 @default.
• W2022834873 cites W2074468494 @default.
• W2022834873 cites W2075082491 @default.
• W2022834873 cites W2080247064 @default.
• W2022834873 cites W2094187011 @default.
• W2022834873 cites W2104649857 @default.
• W2022834873 cites W2105920220 @default.
• W2022834873 cites W2152488901 @default.
• W2022834873 cites W2153581028 @default.
• W2022834873 cites W2302676728 @default.
• W2022834873 cites W2316727422 @default.
• W2022834873 cites W4252706829 @default.
• W2022834873 cites W4360754244 @default.
• W2022834873 doi "https://doi.org/10.1016/0168-8278(90)90106-2" @default.
• W2022834873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2123913" @default.
• W2022834873 hasPublicationYear "1990" @default.
• W2022834873 type Work @default.
• W2022834873 sameAs 2022834873 @default.
• W2022834873 citedByCount "76" @default.
• W2022834873 countsByYear W20228348732012 @default.
• W2022834873 countsByYear W20228348732013 @default.
• W2022834873 countsByYear W20228348732014 @default.
• W2022834873 countsByYear W20228348732016 @default.
• W2022834873 countsByYear W20228348732018 @default.
• W2022834873 countsByYear W20228348732019 @default.
• W2022834873 crossrefType "journal-article" @default.
• W2022834873 hasAuthorship W2022834873A5036810251 @default.
• W2022834873 hasAuthorship W2022834873A5068910750 @default.
• W2022834873 hasAuthorship W2022834873A5079075767 @default.
• W2022834873 hasAuthorship W2022834873A5080844718 @default.
• W2022834873 hasAuthorship W2022834873A5088236321 @default.
• W2022834873 hasAuthorship W2022834873A5090645179 @default.
• W2022834873 hasConcept C126322002 @default.
• W2022834873 hasConcept C141071460 @default.
• W2022834873 hasConcept C159641895 @default.
• W2022834873 hasConcept C2776125364 @default.
• W2022834873 hasConcept C2776988256 @default.
• W2022834873 hasConcept C2777214474 @default.
• W2022834873 hasConcept C2778642596 @default.
• W2022834873 hasConcept C2779199973 @default.
• W2022834873 hasConcept C2779234561 @default.
• W2022834873 hasConcept C2779547328 @default.
• W2022834873 hasConcept C2779837120 @default.
• W2022834873 hasConcept C2780306776 @default.
• W2022834873 hasConcept C42219234 @default.
• W2022834873 hasConcept C54355233 @default.
• W2022834873 hasConcept C71924100 @default.
• W2022834873 hasConcept C86803240 @default.
• W2022834873 hasConcept C90924648 @default.
• W2022834873 hasConceptScore W2022834873C126322002 @default.
• W2022834873 hasConceptScore W2022834873C141071460 @default.
• W2022834873 hasConceptScore W2022834873C159641895 @default.
• W2022834873 hasConceptScore W2022834873C2776125364 @default.
• W2022834873 hasConceptScore W2022834873C2776988256 @default.
• W2022834873 hasConceptScore W2022834873C2777214474 @default.
• W2022834873 hasConceptScore W2022834873C2778642596 @default.
• W2022834873 hasConceptScore W2022834873C2779199973 @default.
• W2022834873 hasConceptScore W2022834873C2779234561 @default.
• W2022834873 hasConceptScore W2022834873C2779547328 @default.
• W2022834873 hasConceptScore W2022834873C2779837120 @default.
• W2022834873 hasConceptScore W2022834873C2780306776 @default.
• W2022834873 hasConceptScore W2022834873C42219234 @default.
• W2022834873 hasConceptScore W2022834873C54355233 @default.
• W2022834873 hasConceptScore W2022834873C71924100 @default.
• W2022834873 hasConceptScore W2022834873C86803240 @default.
• W2022834873 hasConceptScore W2022834873C90924648 @default.
• W2022834873 hasIssue "2" @default.
• W2022834873 hasLocation W20228348731 @default.
• W2022834873 hasLocation W20228348732 @default.
• W2022834873 hasOpenAccess W2022834873 @default.

• next