FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022839023> ?p ?o ?g. }

• W2022839023 endingPage "119" @default.
• W2022839023 startingPage "112" @default.
• W2022839023 abstract "Biphasic effects of 1,25-dihydroxyvitamin D-3 on DNA synthesis were shown in primary cultured (24 h) chick embryo myoblasts exposed to physiological concentrations of the hormone. The sterol stimulated [3H]thymidine incorporation into DNA in proliferating myoblasts, e.g., at early stages of culture prior to cell fusion or in high serum-treated cells. The opposite effects were observed during the subsequent stage of myoblast differentiation in low-serum media. The mitogenic effect of 1,25-dihydroxyvitamin D-3 was correlated with an increase in c-myc mRNA and a decrease in c-fos mRNA levels, whereas its inhibitory action on DNA synthesis was accompanied by increased myofibrillar and microsomal protein synthesis and an elevation of creatine kinase activity, the latter suggesting a stimulation of muscle cell differentiation by the sterol. These data are in agreement with the results of previous morphological studies. Treatment of myoblasts with the calcium ionophore X-537 A or the phorbol ester TPA caused only a transient stimulation of [3H]thymidine incorporation into DNA, which occurred earlier than the response elicited by 1,25-dihydroxyvitamin D-3, suggesting that changes in intracellular Ca2+ and kinase C activity are not major mediators of the hormone effects. A similar temporal profile of changes in calmodulin mRNA levels as that of [3H]thymidine incorporation into DNA was observed after treatment of myoblasts with the sterol, in accordance with the role of calmodulin in the regulation of cell proliferation. 1,25-dihydroxyvitamin D-3 may play a function in embryonic muscle growth and differentiation." @default.
• W2022839023 created "2016-06-24" @default.
• W2022839023 creator A5059268113 @default.
• W2022839023 creator A5062612045 @default.
• W2022839023 creator A5070051089 @default.
• W2022839023 date "1989-11-01" @default.
• W2022839023 modified "2023-09-27" @default.
• W2022839023 title "Modulation of DNA synthesis in cultured muscle cells by 1,25-dihydroxyvitamin D-3" @default.
• W2022839023 cites W1480005617 @default.
• W2022839023 cites W1489567813 @default.
• W2022839023 cites W1489729774 @default.
• W2022839023 cites W1523493483 @default.
• W2022839023 cites W1531695673 @default.
• W2022839023 cites W1579204819 @default.
• W2022839023 cites W1775749144 @default.
• W2022839023 cites W1809073012 @default.
• W2022839023 cites W1975167498 @default.
• W2022839023 cites W1988586478 @default.
• W2022839023 cites W1992472345 @default.
• W2022839023 cites W1996298164 @default.
• W2022839023 cites W1999141041 @default.
• W2022839023 cites W2012883868 @default.
• W2022839023 cites W2018108516 @default.
• W2022839023 cites W2021253208 @default.
• W2022839023 cites W2022525159 @default.
• W2022839023 cites W2036152484 @default.
• W2022839023 cites W2041013238 @default.
• W2022839023 cites W2064896297 @default.
• W2022839023 cites W2074345417 @default.
• W2022839023 cites W2093641160 @default.
• W2022839023 cites W2113524103 @default.
• W2022839023 cites W2117031050 @default.
• W2022839023 cites W2140314600 @default.
• W2022839023 cites W2145708538 @default.
• W2022839023 cites W2149637850 @default.
• W2022839023 cites W2164515753 @default.
• W2022839023 cites W2417343450 @default.
• W2022839023 cites W414608619 @default.
• W2022839023 doi "https://doi.org/10.1016/0167-4889(89)90022-0" @default.
• W2022839023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2510826" @default.
• W2022839023 hasPublicationYear "1989" @default.
• W2022839023 type Work @default.
• W2022839023 sameAs 2022839023 @default.
• W2022839023 citedByCount "43" @default.
• W2022839023 countsByYear W20228390232012 @default.
• W2022839023 countsByYear W20228390232013 @default.
• W2022839023 countsByYear W20228390232014 @default.
• W2022839023 countsByYear W20228390232016 @default.
• W2022839023 countsByYear W20228390232017 @default.
• W2022839023 countsByYear W20228390232020 @default.
• W2022839023 crossrefType "journal-article" @default.
• W2022839023 hasAuthorship W2022839023A5059268113 @default.
• W2022839023 hasAuthorship W2022839023A5062612045 @default.
• W2022839023 hasAuthorship W2022839023A5070051089 @default.
• W2022839023 hasConcept C126322002 @default.
• W2022839023 hasConcept C134018914 @default.
• W2022839023 hasConcept C153911025 @default.
• W2022839023 hasConcept C181199279 @default.
• W2022839023 hasConcept C184235292 @default.
• W2022839023 hasConcept C195794163 @default.
• W2022839023 hasConcept C207200792 @default.
• W2022839023 hasConcept C24998067 @default.
• W2022839023 hasConcept C2776989580 @default.
• W2022839023 hasConcept C2777108182 @default.
• W2022839023 hasConcept C29688787 @default.
• W2022839023 hasConcept C552990157 @default.
• W2022839023 hasConcept C55493867 @default.
• W2022839023 hasConcept C62112901 @default.
• W2022839023 hasConcept C64241487 @default.
• W2022839023 hasConcept C71924100 @default.
• W2022839023 hasConcept C86803240 @default.
• W2022839023 hasConceptScore W2022839023C126322002 @default.
• W2022839023 hasConceptScore W2022839023C134018914 @default.
• W2022839023 hasConceptScore W2022839023C153911025 @default.
• W2022839023 hasConceptScore W2022839023C181199279 @default.
• W2022839023 hasConceptScore W2022839023C184235292 @default.
• W2022839023 hasConceptScore W2022839023C195794163 @default.
• W2022839023 hasConceptScore W2022839023C207200792 @default.
• W2022839023 hasConceptScore W2022839023C24998067 @default.
• W2022839023 hasConceptScore W2022839023C2776989580 @default.
• W2022839023 hasConceptScore W2022839023C2777108182 @default.
• W2022839023 hasConceptScore W2022839023C29688787 @default.
• W2022839023 hasConceptScore W2022839023C552990157 @default.
• W2022839023 hasConceptScore W2022839023C55493867 @default.
• W2022839023 hasConceptScore W2022839023C62112901 @default.
• W2022839023 hasConceptScore W2022839023C64241487 @default.
• W2022839023 hasConceptScore W2022839023C71924100 @default.
• W2022839023 hasConceptScore W2022839023C86803240 @default.
• W2022839023 hasIssue "2" @default.
• W2022839023 hasLocation W20228390231 @default.
• W2022839023 hasLocation W20228390232 @default.
• W2022839023 hasOpenAccess W2022839023 @default.
• W2022839023 hasPrimaryLocation W20228390231 @default.
• W2022839023 hasRelatedWork W1984619393 @default.
• W2022839023 hasRelatedWork W2031737195 @default.
• W2022839023 hasRelatedWork W2034768996 @default.
• W2022839023 hasRelatedWork W2042786471 @default.
• W2022839023 hasRelatedWork W2054992011 @default.

• next