Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022841775> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2022841775 endingPage "300" @default.
- W2022841775 startingPage "293" @default.
- W2022841775 abstract "The high prevalence of obesity and its well documented association with the cardiovascular risk factors diabetes mellitus, dyslipidemia and hypertension represents a major problem for the general health status of industrialized societies. Although numerous studies have shown that genetic factors have a major influence on the regulation of energy homeostasis and the susceptibility to obesity, the genes and predisposing mutations involved are insufficiently understood. Among several known rodent models of obesity due to single gene mutations, mice homozygous for the obese (ob) gene exhibit massive early-onset obesity, hyperphagia, non-insulin-dependent diabetes mellitus, defective thermoregulation and infertility. Recently the ob gene was identified by positional cloning and shown to be mutated in ob/ob mice. Leptin, the product of the ob gene, is a 167-amino acid secreted protein that is synthesized exclusively in adipose tissue. With the exception of ob/ob mice, circulating plasma leptin is elevated in obesity. Administration of recombinant leptin to ob/ob mice reduces fat mass, food intake, hyperglycemia and hyperinsulinemia. The various effects of the hormone are mediated by leptin receptors expressed at high levels in the hypothalamus, but also in several other non-neuronal tissues. A mutation in the leptin receptor gene is responsible for the obese phenotype of db/db mice. Plasma leptin in humans is positively correlated with body fat mass, suggesting that leptin resistance rather than leptin deficiency is a common feature of human obesity. This review briefly summarizes the current status of the rapidly growing evidence that leptin plays an important role in the regulation of body weight and fat deposition." @default.
- W2022841775 created "2016-06-24" @default.
- W2022841775 creator A5019247471 @default.
- W2022841775 creator A5084733320 @default.
- W2022841775 date "2009-07-15" @default.
- W2022841775 modified "2023-10-01" @default.
- W2022841775 title "Regulation of energy balance by leptin" @default.
- W2022841775 doi "https://doi.org/10.1055/s-0029-1211457" @default.
- W2022841775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8886745" @default.
- W2022841775 hasPublicationYear "2009" @default.
- W2022841775 type Work @default.
- W2022841775 sameAs 2022841775 @default.
- W2022841775 citedByCount "192" @default.
- W2022841775 countsByYear W20228417752012 @default.
- W2022841775 countsByYear W20228417752013 @default.
- W2022841775 countsByYear W20228417752014 @default.
- W2022841775 countsByYear W20228417752015 @default.
- W2022841775 countsByYear W20228417752016 @default.
- W2022841775 countsByYear W20228417752017 @default.
- W2022841775 countsByYear W20228417752018 @default.
- W2022841775 countsByYear W20228417752019 @default.
- W2022841775 countsByYear W20228417752020 @default.
- W2022841775 countsByYear W20228417752022 @default.
- W2022841775 countsByYear W20228417752023 @default.
- W2022841775 crossrefType "journal-article" @default.
- W2022841775 hasAuthorship W2022841775A5019247471 @default.
- W2022841775 hasAuthorship W2022841775A5084733320 @default.
- W2022841775 hasConcept C104317684 @default.
- W2022841775 hasConcept C126322002 @default.
- W2022841775 hasConcept C127716648 @default.
- W2022841775 hasConcept C134018914 @default.
- W2022841775 hasConcept C14372207 @default.
- W2022841775 hasConcept C171089720 @default.
- W2022841775 hasConcept C2491326 @default.
- W2022841775 hasConcept C2777003273 @default.
- W2022841775 hasConcept C2777391703 @default.
- W2022841775 hasConcept C2780613262 @default.
- W2022841775 hasConcept C2780988686 @default.
- W2022841775 hasConcept C3018667095 @default.
- W2022841775 hasConcept C3020804800 @default.
- W2022841775 hasConcept C511355011 @default.
- W2022841775 hasConcept C54355233 @default.
- W2022841775 hasConcept C555293320 @default.
- W2022841775 hasConcept C71924100 @default.
- W2022841775 hasConcept C86803240 @default.
- W2022841775 hasConceptScore W2022841775C104317684 @default.
- W2022841775 hasConceptScore W2022841775C126322002 @default.
- W2022841775 hasConceptScore W2022841775C127716648 @default.
- W2022841775 hasConceptScore W2022841775C134018914 @default.
- W2022841775 hasConceptScore W2022841775C14372207 @default.
- W2022841775 hasConceptScore W2022841775C171089720 @default.
- W2022841775 hasConceptScore W2022841775C2491326 @default.
- W2022841775 hasConceptScore W2022841775C2777003273 @default.
- W2022841775 hasConceptScore W2022841775C2777391703 @default.
- W2022841775 hasConceptScore W2022841775C2780613262 @default.
- W2022841775 hasConceptScore W2022841775C2780988686 @default.
- W2022841775 hasConceptScore W2022841775C3018667095 @default.
- W2022841775 hasConceptScore W2022841775C3020804800 @default.
- W2022841775 hasConceptScore W2022841775C511355011 @default.
- W2022841775 hasConceptScore W2022841775C54355233 @default.
- W2022841775 hasConceptScore W2022841775C555293320 @default.
- W2022841775 hasConceptScore W2022841775C71924100 @default.
- W2022841775 hasConceptScore W2022841775C86803240 @default.
- W2022841775 hasIssue "04" @default.
- W2022841775 hasLocation W20228417751 @default.
- W2022841775 hasLocation W20228417752 @default.
- W2022841775 hasOpenAccess W2022841775 @default.
- W2022841775 hasPrimaryLocation W20228417751 @default.
- W2022841775 hasRelatedWork W1976946227 @default.
- W2022841775 hasRelatedWork W1981583644 @default.
- W2022841775 hasRelatedWork W2020449916 @default.
- W2022841775 hasRelatedWork W2022716990 @default.
- W2022841775 hasRelatedWork W2074115578 @default.
- W2022841775 hasRelatedWork W2159934098 @default.
- W2022841775 hasRelatedWork W2166224820 @default.
- W2022841775 hasRelatedWork W2170321707 @default.
- W2022841775 hasRelatedWork W2398688629 @default.
- W2022841775 hasRelatedWork W2772070342 @default.
- W2022841775 hasVolume "104" @default.
- W2022841775 isParatext "false" @default.
- W2022841775 isRetracted "false" @default.
- W2022841775 magId "2022841775" @default.
- W2022841775 workType "article" @default.