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- W2022842077 abstract "The relation between depression and neurological disorders is generally construed as unidirectional and expressed as an increased risk of depression in the presence of a neurological disorder. In the past 15 years, however, data from several studies have suggested the existence of a bidirectional relation between depression and various neurological disorders, including dementia, epilepsy, stroke, and Parkinson's disease. This relation is expressed by an increased risk of occurrence or a worse prognosis of these disorders in individuals with a history of depression. For example, many studies have shown an increased prevalence of depression in patients with dementia. However, using data from a case-register study of almost 23 000 patients with an affective disorder, L Kessing and P Andersen suggested that the relation expressed as the number of major depressive episodes leading to an inpatient admission increased the risk of developing dementia. 1 Kessing LV Andersen PK Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?. J Neurol Neurosurg Psychiatry. 2004; 75: 1662-1666 Crossref PubMed Scopus (309) Google Scholar Thus patients with three admissions had close to a three-times increased rate of dementia (95% CI 0·64–13·2), compared with patients with only one admission. In a separate study of 1003 elderly patients (all with a Mini Mental State score >26), the presence of significant depressive symptoms at baseline predicted a higher risk of cognitive decline 4 years later. 2 Paterniti S Verdier-Taillefer MH Dufouil C et al. Depressive symptoms and cognitive decline in elderly people: longitudinal study. Br J Psychiatry. 2002; 181: 406-410 Crossref PubMed Scopus (191) Google Scholar Structural and functional neuroanatomical changes in primary major depressive disorders might help to explain these data." @default.
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- W2022842077 date "2005-10-01" @default.
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- W2022842077 title "Depression and the risk of neurological disorders" @default.
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