FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022842992> ?p ?o ?g. }

• W2022842992 endingPage "556" @default.
• W2022842992 startingPage "545" @default.
• W2022842992 abstract "We examined alpha-, beta-, and gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell development. We wished to determine if TCR rearrangement and expression was lineage restricted, showed any developmental hierarchy, or could identify new subsets of T cells. Rearrangement of gamma and beta TCR genes occurred early in development but in no set order, and most T-ALLs (22/26) were of sufficient maturity to have rearranged both genes. T-ALLs preferentially rearranged C gamma 2 versus the C gamma 1 complex; no preference within the beta locus was apparent. Once rearranged, the beta TCR continued to be expressed (11/13), whereas the gamma TCR was rarely expressed (3/14). The alpha TCR was expressed only in more mature T-ALLs (8/14) that usually displayed T3. The 3A-1 T cell associated antigen appeared earliest in development followed by T11 and T3. Within pre-B cell ALL a higher incidence of lineage spillover was noted for gamma TCR rearrangements (8/17) than for beta rearrangements (3/17). This also contrasts with the only occasional rearrangement of immunoglobulin (Ig) heavy chains (3/25) in T-ALL. However, in pre-B ALL the pattern of gamma TCR usage was distinct from that of T cells, with the C gamma 1 complex utilized more frequently. Almost all ALLs could be classified as pre-B or T cell in type by combining Ig and TCR genes with monoclonal antibodies recognizing surface antigens, although examples of lineage duality were noted. Unique subpopulations of cells were discovered including two genetically uncommitted ALLs that failed to rearrange either Ig or TCR loci. Moreover, two T lymphoblasts were identified that possessed the T3 molecule but failed to express alpha plus beta TCR genes. These T-ALLs may represent a fortuitous transformation of T cell subsets with alternative T3-Ti complexes." @default.
• W2022842992 created "2016-06-24" @default.
• W2022842992 creator A5016063738 @default.
• W2022842992 creator A5019914745 @default.
• W2022842992 creator A5020347841 @default.
• W2022842992 creator A5027165899 @default.
• W2022842992 creator A5075130859 @default.
• W2022842992 creator A5075887932 @default.
• W2022842992 creator A5079843979 @default.
• W2022842992 date "1987-08-01" @default.
• W2022842992 modified "2023-09-23" @default.
• W2022842992 title "T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia." @default.
• W2022842992 cites W1504600626 @default.
• W2022842992 cites W1529342422 @default.
• W2022842992 cites W1533561364 @default.
• W2022842992 cites W1541171924 @default.
• W2022842992 cites W1564896848 @default.
• W2022842992 cites W1600313928 @default.
• W2022842992 cites W19734691 @default.
• W2022842992 cites W1981335441 @default.
• W2022842992 cites W1981856998 @default.
• W2022842992 cites W1984724325 @default.
• W2022842992 cites W1995986183 @default.
• W2022842992 cites W1997056931 @default.
• W2022842992 cites W1998985814 @default.
• W2022842992 cites W2002594142 @default.
• W2022842992 cites W2004745504 @default.
• W2022842992 cites W2006437800 @default.
• W2022842992 cites W2014669590 @default.
• W2022842992 cites W2017963255 @default.
• W2022842992 cites W2022341531 @default.
• W2022842992 cites W2026615255 @default.
• W2022842992 cites W2032312044 @default.
• W2022842992 cites W2032652840 @default.
• W2022842992 cites W2033010633 @default.
• W2022842992 cites W2033938686 @default.
• W2022842992 cites W2036509722 @default.
• W2022842992 cites W2038165289 @default.
• W2022842992 cites W2038879439 @default.
• W2022842992 cites W2041503596 @default.
• W2022842992 cites W2048137603 @default.
• W2022842992 cites W2050778085 @default.
• W2022842992 cites W2051183563 @default.
• W2022842992 cites W2051985758 @default.
• W2022842992 cites W2052948419 @default.
• W2022842992 cites W2053677240 @default.
• W2022842992 cites W2054878761 @default.
• W2022842992 cites W2060333964 @default.
• W2022842992 cites W2062057016 @default.
• W2022842992 cites W2062832392 @default.
• W2022842992 cites W2069637913 @default.
• W2022842992 cites W2071500044 @default.
• W2022842992 cites W2076899085 @default.
• W2022842992 cites W2079305869 @default.
• W2022842992 cites W2079418862 @default.
• W2022842992 cites W2079588771 @default.
• W2022842992 cites W2081885904 @default.
• W2022842992 cites W2082919075 @default.
• W2022842992 cites W2086143621 @default.
• W2022842992 cites W2089331987 @default.
• W2022842992 cites W2098643663 @default.
• W2022842992 cites W2135215155 @default.
• W2022842992 cites W2142800802 @default.
• W2022842992 cites W2147367754 @default.
• W2022842992 cites W2152171889 @default.
• W2022842992 cites W2163451755 @default.
• W2022842992 cites W2172719686 @default.
• W2022842992 cites W2319793285 @default.
• W2022842992 cites W2337101530 @default.
• W2022842992 cites W2338997062 @default.
• W2022842992 cites W2340010154 @default.
• W2022842992 cites W2340094023 @default.
• W2022842992 cites W2413172769 @default.
• W2022842992 doi "https://doi.org/10.1172/jci113103" @default.
• W2022842992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/442268" @default.
• W2022842992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3497178" @default.
• W2022842992 hasPublicationYear "1987" @default.
• W2022842992 type Work @default.
• W2022842992 sameAs 2022842992 @default.
• W2022842992 citedByCount "79" @default.
• W2022842992 countsByYear W20228429922012 @default.
• W2022842992 countsByYear W20228429922019 @default.
• W2022842992 crossrefType "journal-article" @default.
• W2022842992 hasAuthorship W2022842992A5016063738 @default.
• W2022842992 hasAuthorship W2022842992A5019914745 @default.
• W2022842992 hasAuthorship W2022842992A5020347841 @default.
• W2022842992 hasAuthorship W2022842992A5027165899 @default.
• W2022842992 hasAuthorship W2022842992A5075130859 @default.
• W2022842992 hasAuthorship W2022842992A5075887932 @default.
• W2022842992 hasAuthorship W2022842992A5079843979 @default.
• W2022842992 hasBestOaLocation W20228429921 @default.
• W2022842992 hasConcept C104317684 @default.
• W2022842992 hasConcept C147483822 @default.
• W2022842992 hasConcept C153911025 @default.
• W2022842992 hasConcept C19317047 @default.
• W2022842992 hasConcept C199360897 @default.
• W2022842992 hasConcept C2776090121 @default.
• W2022842992 hasConcept C2776174256 @default.

• next