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- W2022844396 abstract "The separation of basic compounds in high-pH mobile phases results in extended retention, excellent peak shapes and good chromatographic efficiency. A severe decrease in sensitivity with electrospray mass spectrometric detection in positive ion mode (ESI+-MS) is expected under conditions that suppress analyte ionization in solution. We compared the responses of a large number of various basic drugs covering a wide range of hydrophobic (log P 0.09 to 7.6) and basic character (pKa 6.8-10) in LC-ESI+-MS/MS in 0.1% formic acid in water and acetonitrile, to responses in 10mM ammonium hydrogencarbonate buffers of different pH (7.8-11), and acetonitrile. Contrary to common expectations, high-pH mobile phases do not affect negatively the responses of basic compounds in ESI+. Analyte responses and limits of detection are comparable, or most often better in high pH compared to acidic mobile phases." @default.
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- W2022844396 date "2008-02-01" @default.
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- W2022844396 title "Analysis of basic compounds by reversed-phase liquid chromatography–electrospray mass spectrometry in high-pH mobile phases" @default.
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- W2022844396 doi "https://doi.org/10.1016/j.chroma.2007.11.048" @default.
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