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- W2022849967 abstract "A multifunctional carrier combining B/T cell epitopes (i), a built-in vaccine adjuvant (ii), and a universal T cell epitope (iii) for the construction of potent and specific immunogenic conjugates is presented. The IL-1β(163−171) fragment known to reproduce the immunostimulatory and adjuvant effects of the whole IL-1β without possessing any of the pro-inflammatory properties of IL-1β was covalently anchored to the N-terminus of the Sequential Oligopeptide Carrier, SOCn, formed by the repeating tripeptide unit Lys-Aib-Gly. A promiscuous T cell epitope derived from the tetanus toxin, TT(593−599), was also positioned in the carboxy terminus of SOCn as a universal immunogen to provide broad immunogenicity. Selected B/T cell epitopes from the Sm and La/SSB autoantigens, against which is directed the humoral autoimmunity in patients with systemic lupus erythematosus and Sjögren's Syndrome, respectively, were coupled to the Lys-NεH2 groups of the carrier, and the formulated constructs were administered in animals following the conventional immunization protocol of complete/incomplete Freund's adjuvant. The induced immune responses were compared with that produced when the Sm- and La/SSB-reconstituted immunogenic conjugates were injected alone. High titers of specific antibodies recognizing the priming construct, as well as the cognate autoantigen, were obtained when administered alone without the assistance of Freund's adjuvant. It is concluded that our approach provides the conceptual and experimental framework for the development of multifunctional immunogenic conjugates eliciting enhanced, specific, and prolonged humoral response for usage as human vaccine candidates." @default.
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- W2022849967 date "2005-06-10" @default.
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- W2022849967 title "A Peptide Carrier with a Built-In Vaccine Adjuvant: Construction of Immunogenic Conjugates" @default.
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- W2022849967 doi "https://doi.org/10.1021/bc049703m" @default.
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