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• W2022851134 abstract "The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P=0.0012-0.04), and one in the 3'-untranslated region (P=2 x 10(-7)) that displayed associations with UC. Moreover, meprin-alpha mRNA was decreased in inflamed mucosa of IBD patients. Meprin-alpha knockout mice exhibited a more severe intestinal injury and inflammation than their wild-type counterparts following oral administration of dextran sulfate sodium. Collectively, the data implicate MEP1A as a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD." @default.
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• W2022851134 date "2009-05-01" @default.
• W2022851134 modified "2023-09-30" @default.
• W2022851134 title "MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease" @default.
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• W2022851134 doi "https://doi.org/10.1038/mi.2009.3" @default.
• W2022851134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670347" @default.
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