Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022851289> ?p ?o ?g. }
- W2022851289 endingPage "3353" @default.
- W2022851289 startingPage "3344" @default.
- W2022851289 abstract "Abstract Objective Treatment options for rheumatoid arthritis range from symptomatic approaches to modern molecular interventions such as inhibition of inflammatory mediators. Inhibition of inflammation by platelet‐rich plasma (PRP) has been proposed as a treatment for tendinitis and osteoarthritis. The present study was undertaken to investigate the effect of PRP on antigen‐induced arthritis (AIA) of the knee joint in a large animal model. Methods Six‐month‐old pigs (n = 10) were systemically immunized by bovine serum albumin (BSA) injection, and arthritis was induced by intraarticular BSA injection. PRP was injected into the knee joints of 5 of the animals after 2 weeks. An additional 5 animals received no systemic immunization (controls). Signs of arthritis were documented by plain histologic analysis, Safranin O staining, and immunohistochemistry analysis for type II collagen (CII), interleukin‐6 (IL‐6), and vascular endothelial growth factor (VEGF). Interleukin‐1β (IL‐1β), IL‐6, tumor necrosis factor α (TNFα), VEGF, and insulin‐like growth factor 1 (IGF‐1) protein content was measured by Luminex assay. Results In the pigs with AIA, plain histologic analysis revealed severe arthritic changes in the synovium. Safranin O and CII staining showed decreased proteoglycan and CII content in cartilage. Immunohistochemistry analysis revealed increased levels of IL‐6 and VEGF in synovium and cartilage, and protein concentrations of IL‐6, VEGF, IL‐1β, and IGF‐1 in synovium and cartilage were elevated as well; in addition, TNFα protein was increased in cartilage. Treatment with PRP led to attenuation of these arthritic changes in the synovium and cartilage. Conclusion We have described a porcine model of AIA. Experiments using this model demonstrated that PRP can attenuate arthritic changes as assessed histologically and based on protein synthesis of typical inflammatory mediators in the synovial membrane and cartilage." @default.
- W2022851289 created "2016-06-24" @default.
- W2022851289 creator A5004175518 @default.
- W2022851289 creator A5019166148 @default.
- W2022851289 creator A5029544067 @default.
- W2022851289 creator A5039656929 @default.
- W2022851289 creator A5054147971 @default.
- W2022851289 creator A5055531816 @default.
- W2022851289 creator A5057789441 @default.
- W2022851289 creator A5076071583 @default.
- W2022851289 creator A5077525847 @default.
- W2022851289 creator A5090335543 @default.
- W2022851289 date "2011-10-28" @default.
- W2022851289 modified "2023-10-17" @default.
- W2022851289 title "Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint" @default.
- W2022851289 cites W132781887 @default.
- W2022851289 cites W1480259844 @default.
- W2022851289 cites W1538140233 @default.
- W2022851289 cites W1670891845 @default.
- W2022851289 cites W1910182103 @default.
- W2022851289 cites W1966509471 @default.
- W2022851289 cites W1976066154 @default.
- W2022851289 cites W1977117158 @default.
- W2022851289 cites W1978005832 @default.
- W2022851289 cites W1982597887 @default.
- W2022851289 cites W1985111027 @default.
- W2022851289 cites W1987738128 @default.
- W2022851289 cites W2006050540 @default.
- W2022851289 cites W2008439967 @default.
- W2022851289 cites W2008793234 @default.
- W2022851289 cites W2015460060 @default.
- W2022851289 cites W2022422194 @default.
- W2022851289 cites W2023623228 @default.
- W2022851289 cites W2023976647 @default.
- W2022851289 cites W2026269197 @default.
- W2022851289 cites W2027365426 @default.
- W2022851289 cites W2032848182 @default.
- W2022851289 cites W2034251584 @default.
- W2022851289 cites W2037328562 @default.
- W2022851289 cites W2041368501 @default.
- W2022851289 cites W2044378191 @default.
- W2022851289 cites W2056813079 @default.
- W2022851289 cites W2064563396 @default.
- W2022851289 cites W2072361992 @default.
- W2022851289 cites W2081249822 @default.
- W2022851289 cites W2086521814 @default.
- W2022851289 cites W2087905782 @default.
- W2022851289 cites W2096813909 @default.
- W2022851289 cites W2136652158 @default.
- W2022851289 cites W2136871488 @default.
- W2022851289 cites W2138305712 @default.
- W2022851289 cites W2139457077 @default.
- W2022851289 cites W2144342799 @default.
- W2022851289 cites W2148373785 @default.
- W2022851289 cites W2155493931 @default.
- W2022851289 cites W2155702314 @default.
- W2022851289 cites W2168789685 @default.
- W2022851289 cites W2168902269 @default.
- W2022851289 cites W2187685373 @default.
- W2022851289 cites W68704341 @default.
- W2022851289 cites W976481605 @default.
- W2022851289 doi "https://doi.org/10.1002/art.30547" @default.
- W2022851289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21769848" @default.
- W2022851289 hasPublicationYear "2011" @default.
- W2022851289 type Work @default.
- W2022851289 sameAs 2022851289 @default.
- W2022851289 citedByCount "94" @default.
- W2022851289 countsByYear W20228512892012 @default.
- W2022851289 countsByYear W20228512892013 @default.
- W2022851289 countsByYear W20228512892014 @default.
- W2022851289 countsByYear W20228512892015 @default.
- W2022851289 countsByYear W20228512892016 @default.
- W2022851289 countsByYear W20228512892017 @default.
- W2022851289 countsByYear W20228512892018 @default.
- W2022851289 countsByYear W20228512892019 @default.
- W2022851289 countsByYear W20228512892020 @default.
- W2022851289 countsByYear W20228512892021 @default.
- W2022851289 countsByYear W20228512892022 @default.
- W2022851289 countsByYear W20228512892023 @default.
- W2022851289 crossrefType "journal-article" @default.
- W2022851289 hasAuthorship W2022851289A5004175518 @default.
- W2022851289 hasAuthorship W2022851289A5019166148 @default.
- W2022851289 hasAuthorship W2022851289A5029544067 @default.
- W2022851289 hasAuthorship W2022851289A5039656929 @default.
- W2022851289 hasAuthorship W2022851289A5054147971 @default.
- W2022851289 hasAuthorship W2022851289A5055531816 @default.
- W2022851289 hasAuthorship W2022851289A5057789441 @default.
- W2022851289 hasAuthorship W2022851289A5076071583 @default.
- W2022851289 hasAuthorship W2022851289A5077525847 @default.
- W2022851289 hasAuthorship W2022851289A5090335543 @default.
- W2022851289 hasConcept C105702510 @default.
- W2022851289 hasConcept C126322002 @default.
- W2022851289 hasConcept C142724271 @default.
- W2022851289 hasConcept C167734588 @default.
- W2022851289 hasConcept C17991360 @default.
- W2022851289 hasConcept C203014093 @default.
- W2022851289 hasConcept C204232928 @default.
- W2022851289 hasConcept C204787440 @default.