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• W2022851867 startingPage "3371" @default.
• W2022851867 abstract "There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha-Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha-lipoic acid might have beneficial effects in HD patients." @default.
• W2022851867 created "2016-06-24" @default.
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• W2022851867 date "2001-10-01" @default.
• W2022851867 modified "2023-10-14" @default.
• W2022851867 title "Lipoic acid improves survival in transgenic mouse models of Huntington's disease" @default.
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• W2022851867 doi "https://doi.org/10.1097/00001756-200110290-00044" @default.
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