Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022852477> ?p ?o ?g. }
- W2022852477 endingPage "R1249" @default.
- W2022852477 startingPage "R1244" @default.
- W2022852477 abstract "The mitochondrial mass of rat brain and liver remained unchanged on aging in young adults, old adults, and senescent animals (28, 60, and 92 wk of age); the values were 15–17 and 29–31 mg protein/g for brain and liver, respectively. The whole aging process was associated with an increased content of the oxidation products, thiobarbituric acid-reactive substances and protein carbonyls, by 61–69% in brain and 36–45% in liver, respectively. The activities of critical enzymes for mitochondrial function, mitochondrial nitric oxide synthase, Mn-superoxide dismutase, complex I, and complex IV, decreased progressively during aging with activity losses of 73, 37, 29, and 28%, respectively, in the brain and 47, 46, 30, and 24% in the liver of senescent rats compared with young adults. Brain mitochondria isolated from aged rats showed increased mitochondrial fragility, as assayed by mitochondrial marker enzyme activities in the postmitochondrial supernatant, and increased volume and water permeability, as assayed by light scattering. Liver mitochondria isolated from young and old rats did not show differences in fragility and water permeability. A subpopulation of brain mitochondria with increased size and fragility was differentiated in aging rats, whereas liver showed a homogeneous mitochondrial population." @default.
- W2022852477 created "2016-06-24" @default.
- W2022852477 creator A5018281101 @default.
- W2022852477 creator A5077692069 @default.
- W2022852477 date "2004-11-01" @default.
- W2022852477 modified "2023-10-10" @default.
- W2022852477 title "Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging" @default.
- W2022852477 cites W134928204 @default.
- W2022852477 cites W1488808855 @default.
- W2022852477 cites W1489253375 @default.
- W2022852477 cites W149805343 @default.
- W2022852477 cites W1506520614 @default.
- W2022852477 cites W1545371073 @default.
- W2022852477 cites W1585796965 @default.
- W2022852477 cites W1750690213 @default.
- W2022852477 cites W1850791929 @default.
- W2022852477 cites W1969856624 @default.
- W2022852477 cites W1974817453 @default.
- W2022852477 cites W1977328014 @default.
- W2022852477 cites W1979905257 @default.
- W2022852477 cites W1991615758 @default.
- W2022852477 cites W2004079184 @default.
- W2022852477 cites W2005325031 @default.
- W2022852477 cites W2005381951 @default.
- W2022852477 cites W2009426634 @default.
- W2022852477 cites W2010004460 @default.
- W2022852477 cites W2014007422 @default.
- W2022852477 cites W2023945500 @default.
- W2022852477 cites W2025028134 @default.
- W2022852477 cites W2025978032 @default.
- W2022852477 cites W2026610291 @default.
- W2022852477 cites W2027395393 @default.
- W2022852477 cites W2030134419 @default.
- W2022852477 cites W2030496404 @default.
- W2022852477 cites W2040215374 @default.
- W2022852477 cites W2042706799 @default.
- W2022852477 cites W2042801832 @default.
- W2022852477 cites W2043286970 @default.
- W2022852477 cites W2049212848 @default.
- W2022852477 cites W2075943643 @default.
- W2022852477 cites W2081595932 @default.
- W2022852477 cites W2085115255 @default.
- W2022852477 cites W2085396235 @default.
- W2022852477 cites W2091380103 @default.
- W2022852477 cites W2094466584 @default.
- W2022852477 cites W2113007696 @default.
- W2022852477 cites W2113595720 @default.
- W2022852477 cites W2132826785 @default.
- W2022852477 cites W2138758680 @default.
- W2022852477 cites W2164772129 @default.
- W2022852477 cites W2200701933 @default.
- W2022852477 cites W2218000086 @default.
- W2022852477 cites W2328722618 @default.
- W2022852477 cites W4211173016 @default.
- W2022852477 doi "https://doi.org/10.1152/ajpregu.00226.2004" @default.
- W2022852477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15271654" @default.
- W2022852477 hasPublicationYear "2004" @default.
- W2022852477 type Work @default.
- W2022852477 sameAs 2022852477 @default.
- W2022852477 citedByCount "250" @default.
- W2022852477 countsByYear W20228524772012 @default.
- W2022852477 countsByYear W20228524772013 @default.
- W2022852477 countsByYear W20228524772014 @default.
- W2022852477 countsByYear W20228524772015 @default.
- W2022852477 countsByYear W20228524772016 @default.
- W2022852477 countsByYear W20228524772017 @default.
- W2022852477 countsByYear W20228524772018 @default.
- W2022852477 countsByYear W20228524772019 @default.
- W2022852477 countsByYear W20228524772020 @default.
- W2022852477 countsByYear W20228524772021 @default.
- W2022852477 countsByYear W20228524772022 @default.
- W2022852477 countsByYear W20228524772023 @default.
- W2022852477 crossrefType "journal-article" @default.
- W2022852477 hasAuthorship W2022852477A5018281101 @default.
- W2022852477 hasAuthorship W2022852477A5077692069 @default.
- W2022852477 hasConcept C111133373 @default.
- W2022852477 hasConcept C126322002 @default.
- W2022852477 hasConcept C134018914 @default.
- W2022852477 hasConcept C13591479 @default.
- W2022852477 hasConcept C181199279 @default.
- W2022852477 hasConcept C185592680 @default.
- W2022852477 hasConcept C190283241 @default.
- W2022852477 hasConcept C2775838275 @default.
- W2022852477 hasConcept C2776151105 @default.
- W2022852477 hasConcept C2777504301 @default.
- W2022852477 hasConcept C2777622882 @default.
- W2022852477 hasConcept C2780829032 @default.
- W2022852477 hasConcept C28859421 @default.
- W2022852477 hasConcept C2908647359 @default.
- W2022852477 hasConcept C31573885 @default.
- W2022852477 hasConcept C519581460 @default.
- W2022852477 hasConcept C55493867 @default.
- W2022852477 hasConcept C71924100 @default.
- W2022852477 hasConcept C86803240 @default.
- W2022852477 hasConcept C99454951 @default.
- W2022852477 hasConceptScore W2022852477C111133373 @default.
- W2022852477 hasConceptScore W2022852477C126322002 @default.
- W2022852477 hasConceptScore W2022852477C134018914 @default.