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• W2022853331 endingPage "266" @default.
• W2022853331 startingPage "260" @default.
• W2022853331 abstract "Brittleness is one of the important material properties that influences the success or failure of powder compaction. We have discovered that the reciprocal of diametrical elastic strain at fracture is the most suitable tablet brittleness indices (TBIs) for quantifying brittleness of pharmaceutical tablets. The new strain based TBI is supported by both theoretical considerations and a systematic statistical analysis of friability data. It is sufficiently sensitive to changes in both tablet compositions and compaction parameters. For all tested materials, it correctly shows that tablet brittleness increases with increasing tablet porosity for the same powder. In addition, TBI increases with increasing content of a brittle excipient, lactose monohydrate, in the mixtures with a plastic excipient, microcrystalline cellulose. A probability map for achieving less than 1% tablet friability at various combinations of tablet tensile strength and TBI was constructed. Data from marketed tablets validate this probability map and a TBI value of 150 is recommended as the upper limit for pharmaceutical tablets. This TBI can be calculated from the data routinely obtained during tablet diametrical breaking test, which is commonly performed for assessing tablet mechanical strength. Therefore, it is ready for adoption for quantifying tablet brittleness to guide tablet formulation development since it does not require additional experimental work." @default.
• W2022853331 created "2016-06-24" @default.
• W2022853331 creator A5011151975 @default.
• W2022853331 creator A5089277775 @default.
• W2022853331 date "2015-06-01" @default.
• W2022853331 modified "2023-10-16" @default.
• W2022853331 title "A new tablet brittleness index" @default.
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• W2022853331 doi "https://doi.org/10.1016/j.ejpb.2015.04.007" @default.
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