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- W2022853814 abstract "Quercetin, a ubiquitous flavonoid in plants, inhibited the incorporation of [32P]inorganic phosphate (32Pi) into phospholipid of HeLa cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Among the flavonoids tested, luteolin was the most effective in inhibiting the action of TPA. Studies on structure-activity relationships demonstrated that more hydroxylated flavones and flavonols had stronger inhibitory effects. Quercetin and luteolin also inhibited enhancement of 32Pi-incorporation into phospholipid by dihydroteleocidin B, another potent tumor promoter. The inhibitory effect of quercetin on the biological action of tumor promoters is interesting in relation to the non-carcinogenicity of this flavonoid in animals, in spite of its mutagenicity." @default.
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- W2022853814 date "1983-11-01" @default.
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- W2022853814 title "Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters" @default.
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- W2022853814 doi "https://doi.org/10.1016/0304-3835(83)90075-7" @default.
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