Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022854476> ?p ?o ?g. }
- W2022854476 endingPage "293" @default.
- W2022854476 startingPage "286" @default.
- W2022854476 abstract "In addition to immunologic derangement, hematological abnormalities have been reported in the majority of patients with acquired immunodeficiency syndrome (AIDS). In this study 15 patients with AIDS or AIDS-related complex (ARC) were evaluated for the in vitro growth of hemopoietic progenitor cells. In all patients a significant reduction of growth (mean +/- SEM) of colony-forming unit-granulocyte, erythrocyte, macrophage, (megakaryocyte) (CFU-GEM) (1.2 +/- 0.3), burst-forming unit-erythroid (BFU-E) (17 +/- 10), CFU-megakaryocyte (CFU-Mk) (1.7 +/- 0.6), and CFU-granulocyte-macrophage (CFU-GM) (35 +/- 10) was observed in comparison with normal controls. Depletion of T cells from the bone marrow before culture led to a significant increase in colony growth, which indicated an imbalance of the normally modulating T cell subsets. This increase was reversed by readdition of autologous T cells causing a decrease in colony growth to a degree, dependent on the T4 to T8 ratio. A decreased number of hemopoietic progenitor cells and/or a defective modulation of progenitor cell growth, normally carried out by T lymphocyte subsets, might be the cause of the hematological abnormalities in AIDS patients." @default.
- W2022854476 created "2016-06-24" @default.
- W2022854476 creator A5013231760 @default.
- W2022854476 creator A5048448909 @default.
- W2022854476 creator A5066213019 @default.
- W2022854476 date "1987-08-01" @default.
- W2022854476 modified "2023-09-29" @default.
- W2022854476 title "Defective in vitro growth of the hemopoietic progenitor cells in the acquired immunodeficiency syndrome." @default.
- W2022854476 cites W1493755175 @default.
- W2022854476 cites W1504229548 @default.
- W2022854476 cites W1966814642 @default.
- W2022854476 cites W1968873679 @default.
- W2022854476 cites W1969918569 @default.
- W2022854476 cites W1970587354 @default.
- W2022854476 cites W1977282539 @default.
- W2022854476 cites W1984340871 @default.
- W2022854476 cites W1991337645 @default.
- W2022854476 cites W1996221727 @default.
- W2022854476 cites W200132638 @default.
- W2022854476 cites W2018759145 @default.
- W2022854476 cites W2032905651 @default.
- W2022854476 cites W2034001362 @default.
- W2022854476 cites W2040243725 @default.
- W2022854476 cites W2043218931 @default.
- W2022854476 cites W2046690158 @default.
- W2022854476 cites W2053665678 @default.
- W2022854476 cites W2054955535 @default.
- W2022854476 cites W2056064314 @default.
- W2022854476 cites W2060641378 @default.
- W2022854476 cites W2061130650 @default.
- W2022854476 cites W2064632541 @default.
- W2022854476 cites W2068021117 @default.
- W2022854476 cites W2069658043 @default.
- W2022854476 cites W2078715033 @default.
- W2022854476 cites W2082865861 @default.
- W2022854476 cites W2084868357 @default.
- W2022854476 cites W2088613116 @default.
- W2022854476 cites W2097779050 @default.
- W2022854476 cites W2218895233 @default.
- W2022854476 cites W2319153630 @default.
- W2022854476 cites W2320441301 @default.
- W2022854476 cites W2334837504 @default.
- W2022854476 cites W2334923455 @default.
- W2022854476 cites W2397202651 @default.
- W2022854476 cites W2409061835 @default.
- W2022854476 cites W2428819485 @default.
- W2022854476 cites W70261316 @default.
- W2022854476 cites W96083460 @default.
- W2022854476 doi "https://doi.org/10.1172/jci113071" @default.
- W2022854476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/442236" @default.
- W2022854476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3497175" @default.
- W2022854476 hasPublicationYear "1987" @default.
- W2022854476 type Work @default.
- W2022854476 sameAs 2022854476 @default.
- W2022854476 citedByCount "160" @default.
- W2022854476 countsByYear W20228544762013 @default.
- W2022854476 countsByYear W20228544762014 @default.
- W2022854476 countsByYear W20228544762016 @default.
- W2022854476 countsByYear W20228544762017 @default.
- W2022854476 countsByYear W20228544762020 @default.
- W2022854476 countsByYear W20228544762021 @default.
- W2022854476 countsByYear W20228544762022 @default.
- W2022854476 crossrefType "journal-article" @default.
- W2022854476 hasAuthorship W2022854476A5013231760 @default.
- W2022854476 hasAuthorship W2022854476A5048448909 @default.
- W2022854476 hasAuthorship W2022854476A5066213019 @default.
- W2022854476 hasBestOaLocation W20228544761 @default.
- W2022854476 hasConcept C109159458 @default.
- W2022854476 hasConcept C192285135 @default.
- W2022854476 hasConcept C201750760 @default.
- W2022854476 hasConcept C202751555 @default.
- W2022854476 hasConcept C203014093 @default.
- W2022854476 hasConcept C2777607303 @default.
- W2022854476 hasConcept C2777983669 @default.
- W2022854476 hasConcept C2779705218 @default.
- W2022854476 hasConcept C2780007613 @default.
- W2022854476 hasConcept C28328180 @default.
- W2022854476 hasConcept C2910905871 @default.
- W2022854476 hasConcept C523546767 @default.
- W2022854476 hasConcept C54355233 @default.
- W2022854476 hasConcept C55493867 @default.
- W2022854476 hasConcept C86803240 @default.
- W2022854476 hasConcept C8891405 @default.
- W2022854476 hasConcept C95444343 @default.
- W2022854476 hasConceptScore W2022854476C109159458 @default.
- W2022854476 hasConceptScore W2022854476C192285135 @default.
- W2022854476 hasConceptScore W2022854476C201750760 @default.
- W2022854476 hasConceptScore W2022854476C202751555 @default.
- W2022854476 hasConceptScore W2022854476C203014093 @default.
- W2022854476 hasConceptScore W2022854476C2777607303 @default.
- W2022854476 hasConceptScore W2022854476C2777983669 @default.
- W2022854476 hasConceptScore W2022854476C2779705218 @default.
- W2022854476 hasConceptScore W2022854476C2780007613 @default.
- W2022854476 hasConceptScore W2022854476C28328180 @default.
- W2022854476 hasConceptScore W2022854476C2910905871 @default.
- W2022854476 hasConceptScore W2022854476C523546767 @default.
- W2022854476 hasConceptScore W2022854476C54355233 @default.
- W2022854476 hasConceptScore W2022854476C55493867 @default.