Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022854575> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2022854575 endingPage "1829" @default.
- W2022854575 startingPage "1823" @default.
- W2022854575 abstract "OBJECTIVE: To assess if low (1.25 mg) and/or standard (5 mg) doses of the ACE inhibitor ramipril could prevent progression of microalbuminuria (incipient diabetic nephropathy) in normotensive type 1 diabetic patients. RESEARCH DESIGN AND METHODS: This study, using a multicenter randomized placebo-controlled double-blind parallel group, was conducted over 2 years in 28 outpatient diabetic clinics in the U.K. and Ireland. We screened 334 type 1 diabetic patients with suspected microalbuminuria and normal blood pressure; of these, 140 patients 18-65 years of age with a diagnosis of type 1 diabetes and persistent microalbuminuria, defined as urinary albumin excretion rate (AER) of 20-200 microg/min, were enrolled in the study. RESULTS: The proportion of patients progressing to macroalbuminuria was reduced in the ramipril groups but did not reach statistical significance over 2 years. AER was significantly lower at year 2 in the combined ramipril-treated patients versus placebo (P = 0.013). More patients on ramipril regressed to normoalbuminuria (<20 microg/min), with 11% for 1.25 mg ramipril, 20% for 5 mg ramipril, and 4% for placebo (P = 0.053). Blood pressure was significantly reduced to a similar extent with both 1.25 and 5 mg ramipril. Supine systolic blood pressure increased from 130 to 134 mmHg in the placebo group and fell in the 1.25 mg ramipril group (from 132 to 129 mmHg) and in the 5 mg ramipril group (from 134 to 130 mmHg) (P = 0.003, compared with placebo). No statistically significant changes were observed in glomerular filtration rate (GFR) between the placebo- and ramipril-treated groups during the 2-year period. CONCLUSIONS: Microalbuminuria is reduced significantly by ramipril treatment in type 1 diabetic patients without hypertension. Although the magnitude of the response was greater, there is no significant difference between responses to 1.25 or 5 mg ramipril. Small but highly significant reductions in systolic and mean arterial pressures occur in ramipril-treated patients. GFR is stable at this stage of the evolution of diabetic nephropathy and is unaffected by ramipril treatment for 2 years." @default.
- W2022854575 created "2016-06-24" @default.
- W2022854575 creator A5008621821 @default.
- W2022854575 creator A5049693275 @default.
- W2022854575 creator A5063312418 @default.
- W2022854575 creator A5075232700 @default.
- W2022854575 creator A5084853808 @default.
- W2022854575 date "2000-12-01" @default.
- W2022854575 modified "2023-10-16" @default.
- W2022854575 title "Low-dose ramipril reduces microalbuminuria in type 1 diabetic patients without hypertension: results of a randomized controlled trial." @default.
- W2022854575 doi "https://doi.org/10.2337/diacare.23.12.1823" @default.
- W2022854575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11128360" @default.
- W2022854575 hasPublicationYear "2000" @default.
- W2022854575 type Work @default.
- W2022854575 sameAs 2022854575 @default.
- W2022854575 citedByCount "98" @default.
- W2022854575 countsByYear W20228545752012 @default.
- W2022854575 countsByYear W20228545752013 @default.
- W2022854575 countsByYear W20228545752014 @default.
- W2022854575 countsByYear W20228545752015 @default.
- W2022854575 countsByYear W20228545752016 @default.
- W2022854575 countsByYear W20228545752017 @default.
- W2022854575 countsByYear W20228545752018 @default.
- W2022854575 countsByYear W20228545752020 @default.
- W2022854575 countsByYear W20228545752021 @default.
- W2022854575 countsByYear W20228545752022 @default.
- W2022854575 countsByYear W20228545752023 @default.
- W2022854575 crossrefType "journal-article" @default.
- W2022854575 hasAuthorship W2022854575A5008621821 @default.
- W2022854575 hasAuthorship W2022854575A5049693275 @default.
- W2022854575 hasAuthorship W2022854575A5063312418 @default.
- W2022854575 hasAuthorship W2022854575A5075232700 @default.
- W2022854575 hasAuthorship W2022854575A5084853808 @default.
- W2022854575 hasBestOaLocation W20228545751 @default.
- W2022854575 hasConcept C126322002 @default.
- W2022854575 hasConcept C126894567 @default.
- W2022854575 hasConcept C134018914 @default.
- W2022854575 hasConcept C142724271 @default.
- W2022854575 hasConcept C204787440 @default.
- W2022854575 hasConcept C27016395 @default.
- W2022854575 hasConcept C27081682 @default.
- W2022854575 hasConcept C2777180221 @default.
- W2022854575 hasConcept C2779611605 @default.
- W2022854575 hasConcept C2779888176 @default.
- W2022854575 hasConcept C2779922275 @default.
- W2022854575 hasConcept C2781203188 @default.
- W2022854575 hasConcept C555293320 @default.
- W2022854575 hasConcept C71924100 @default.
- W2022854575 hasConcept C84393581 @default.
- W2022854575 hasConceptScore W2022854575C126322002 @default.
- W2022854575 hasConceptScore W2022854575C126894567 @default.
- W2022854575 hasConceptScore W2022854575C134018914 @default.
- W2022854575 hasConceptScore W2022854575C142724271 @default.
- W2022854575 hasConceptScore W2022854575C204787440 @default.
- W2022854575 hasConceptScore W2022854575C27016395 @default.
- W2022854575 hasConceptScore W2022854575C27081682 @default.
- W2022854575 hasConceptScore W2022854575C2777180221 @default.
- W2022854575 hasConceptScore W2022854575C2779611605 @default.
- W2022854575 hasConceptScore W2022854575C2779888176 @default.
- W2022854575 hasConceptScore W2022854575C2779922275 @default.
- W2022854575 hasConceptScore W2022854575C2781203188 @default.
- W2022854575 hasConceptScore W2022854575C555293320 @default.
- W2022854575 hasConceptScore W2022854575C71924100 @default.
- W2022854575 hasConceptScore W2022854575C84393581 @default.
- W2022854575 hasIssue "12" @default.
- W2022854575 hasLocation W20228545751 @default.
- W2022854575 hasLocation W20228545752 @default.
- W2022854575 hasOpenAccess W2022854575 @default.
- W2022854575 hasPrimaryLocation W20228545751 @default.
- W2022854575 hasRelatedWork W1801358138 @default.
- W2022854575 hasRelatedWork W2006242568 @default.
- W2022854575 hasRelatedWork W2010554522 @default.
- W2022854575 hasRelatedWork W2025439636 @default.
- W2022854575 hasRelatedWork W2032111989 @default.
- W2022854575 hasRelatedWork W2038657938 @default.
- W2022854575 hasRelatedWork W2104195310 @default.
- W2022854575 hasRelatedWork W2391103614 @default.
- W2022854575 hasRelatedWork W4246548707 @default.
- W2022854575 hasRelatedWork W4301386985 @default.
- W2022854575 hasVolume "23" @default.
- W2022854575 isParatext "false" @default.
- W2022854575 isRetracted "false" @default.
- W2022854575 magId "2022854575" @default.
- W2022854575 workType "article" @default.