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- W2022857511 abstract "Calpains are calcium-modulated proteases which respond to Ca2+ signals by removing limited portions of protein substrates, thereby irreversibly modifying their function(s). Members of this protease family are present in a variety of organisms ranging from mammals to plants; some of them are ubiquitously expressed, while others are tissue specific. Although calpains are apparently involved in a multitude of physiological and pathological events, their functions are still poorly understood. In two cases, however, the alteration of a member of the calpain family has been clearly identified as being responsible for a human disease: the loss of function of calpain 3 causes limb girdle muscular dystrophy type 2A, and mutations in the gene coding for calpain 10 have been shown to correlate with non-insulin-dependent diabetes." @default.
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- W2022857511 creator A5058573872 @default.
- W2022857511 date "2004-10-01" @default.
- W2022857511 modified "2023-10-13" @default.
- W2022857511 title "Calpain-related diseases" @default.
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- W2022857511 doi "https://doi.org/10.1016/j.bbrc.2004.07.126" @default.
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