Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022859914> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2022859914 endingPage "1712" @default.
- W2022859914 startingPage "1703" @default.
- W2022859914 abstract "With the recent demonstration of a continuous electrophoretic moving bed enantiomer separation at mg/h throughputs, interest has now turned to scaling up the process for use as a benchtop pharmaceutical production tool. To scale the method, a steady-state mathematical model was developed that predicts the process response to changes in input feed rate and counterflow or moving bed velocities. The vortex-stabilized apparatus used for the separation was modeled using four regions based on the different hydrodynamic flows in each section. Concentration profiles were then derived on the basis of the properties of the Piperoxan-sulfated beta-cyclodextrin system being studied. The effects of different regional flow rates on the concentration profiles were evaluated and used to predict the maximum processing rate and the hydrodynamic profiles required for a separation. Although the model was able to qualitatively predict the shapes of the concentration profiles and show where the theoretical limits of operation existed, it was not able to quantitatively match the data from actual enantiomer separations to better than 50% accuracy. This is believed to be due to the simplifying assumptions involved, namely, the neglect of electric field variations and the lack of a competitive binding isotherm in the analysis. Although the model cannot accurately predict concentrations from a separation, it provides a good theoretical framework for analyzing how the process responds to changes in counterflow rate, feed rate, and the properties of the molecules being separated." @default.
- W2022859914 created "2016-06-24" @default.
- W2022859914 creator A5019019814 @default.
- W2022859914 creator A5054071526 @default.
- W2022859914 date "2003-01-01" @default.
- W2022859914 modified "2023-09-30" @default.
- W2022859914 title "Development of a Segmented Model for a Continuous Electrophoretic Moving Bed Enantiomer Separation" @default.
- W2022859914 cites W2000442037 @default.
- W2022859914 cites W2005799053 @default.
- W2022859914 cites W2009368029 @default.
- W2022859914 cites W2019252123 @default.
- W2022859914 cites W2021560264 @default.
- W2022859914 cites W2040066028 @default.
- W2022859914 cites W2112176018 @default.
- W2022859914 cites W2114437820 @default.
- W2022859914 cites W2199795547 @default.
- W2022859914 cites W2325643658 @default.
- W2022859914 cites W2335676503 @default.
- W2022859914 cites W4252816543 @default.
- W2022859914 doi "https://doi.org/10.1021/bp034072g" @default.
- W2022859914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656145" @default.
- W2022859914 hasPublicationYear "2003" @default.
- W2022859914 type Work @default.
- W2022859914 sameAs 2022859914 @default.
- W2022859914 citedByCount "10" @default.
- W2022859914 countsByYear W20228599142013 @default.
- W2022859914 countsByYear W20228599142019 @default.
- W2022859914 crossrefType "journal-article" @default.
- W2022859914 hasAuthorship W2022859914A5019019814 @default.
- W2022859914 hasAuthorship W2022859914A5054071526 @default.
- W2022859914 hasConcept C105795698 @default.
- W2022859914 hasConcept C111919701 @default.
- W2022859914 hasConcept C121332964 @default.
- W2022859914 hasConcept C150394285 @default.
- W2022859914 hasConcept C172120300 @default.
- W2022859914 hasConcept C178790620 @default.
- W2022859914 hasConcept C185592680 @default.
- W2022859914 hasConcept C186060115 @default.
- W2022859914 hasConcept C2524010 @default.
- W2022859914 hasConcept C2776061190 @default.
- W2022859914 hasConcept C2778088075 @default.
- W2022859914 hasConcept C2780232233 @default.
- W2022859914 hasConcept C33923547 @default.
- W2022859914 hasConcept C41008148 @default.
- W2022859914 hasConcept C43617362 @default.
- W2022859914 hasConcept C486523 @default.
- W2022859914 hasConcept C57879066 @default.
- W2022859914 hasConcept C86803240 @default.
- W2022859914 hasConcept C98045186 @default.
- W2022859914 hasConcept C99844830 @default.
- W2022859914 hasConceptScore W2022859914C105795698 @default.
- W2022859914 hasConceptScore W2022859914C111919701 @default.
- W2022859914 hasConceptScore W2022859914C121332964 @default.
- W2022859914 hasConceptScore W2022859914C150394285 @default.
- W2022859914 hasConceptScore W2022859914C172120300 @default.
- W2022859914 hasConceptScore W2022859914C178790620 @default.
- W2022859914 hasConceptScore W2022859914C185592680 @default.
- W2022859914 hasConceptScore W2022859914C186060115 @default.
- W2022859914 hasConceptScore W2022859914C2524010 @default.
- W2022859914 hasConceptScore W2022859914C2776061190 @default.
- W2022859914 hasConceptScore W2022859914C2778088075 @default.
- W2022859914 hasConceptScore W2022859914C2780232233 @default.
- W2022859914 hasConceptScore W2022859914C33923547 @default.
- W2022859914 hasConceptScore W2022859914C41008148 @default.
- W2022859914 hasConceptScore W2022859914C43617362 @default.
- W2022859914 hasConceptScore W2022859914C486523 @default.
- W2022859914 hasConceptScore W2022859914C57879066 @default.
- W2022859914 hasConceptScore W2022859914C86803240 @default.
- W2022859914 hasConceptScore W2022859914C98045186 @default.
- W2022859914 hasConceptScore W2022859914C99844830 @default.
- W2022859914 hasIssue "6" @default.
- W2022859914 hasLocation W20228599141 @default.
- W2022859914 hasLocation W20228599142 @default.
- W2022859914 hasOpenAccess W2022859914 @default.
- W2022859914 hasPrimaryLocation W20228599141 @default.
- W2022859914 hasRelatedWork W1580066879 @default.
- W2022859914 hasRelatedWork W167020229 @default.
- W2022859914 hasRelatedWork W1968939682 @default.
- W2022859914 hasRelatedWork W2011496689 @default.
- W2022859914 hasRelatedWork W2029340849 @default.
- W2022859914 hasRelatedWork W2035049039 @default.
- W2022859914 hasRelatedWork W2123542616 @default.
- W2022859914 hasRelatedWork W2143398766 @default.
- W2022859914 hasRelatedWork W2357816337 @default.
- W2022859914 hasRelatedWork W2372875043 @default.
- W2022859914 hasVolume "19" @default.
- W2022859914 isParatext "false" @default.
- W2022859914 isRetracted "false" @default.
- W2022859914 magId "2022859914" @default.
- W2022859914 workType "article" @default.