Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022861057> ?p ?o ?g. }
- W2022861057 endingPage "922" @default.
- W2022861057 startingPage "912" @default.
- W2022861057 abstract "RL95-2 endometrial cancer cells were used to study cytochrome P450-mediated chemopreventative mechanisms of four flavonoids found in foods. To investigate enzymatic CYP1 inhibition, intact cells were induced with benzo(a)pyrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Quercetin, kaempferol and myricetin inhibited CYP1 activity dose-dependently with IC50s ranging from 2.2 to 4 μM; while amentoflavone was inactive. Further experiments were designed to determine if flavonoids also interacted with the AhR or caused a decrease in CYP1 protein or mRNA expression. CYP1A1 protein expression was inhibited in cells co-treated with TCDD and quercetin, kaempferol or myricetin compared with TCDD alone, but amentoflavone was ineffective. Relatively higher (∼7-fold) basal levels of CYP1B1 protein were not significantly affected by flavonoid treatments. In general, at the message level significant inhibition of induced CYP1A1 or CYP1B1 was not detected following flavonoid cotreatment. Despite the common inhibitory effects of quercetin, kaempferol, and myricetin on induced CYP1A1-dependent activity and protein expression, the mechanisms of CYP1 inhibition in this cell line are complex and dependent on the CYP gene, AhR inducer and the flavonoid." @default.
- W2022861057 created "2016-06-24" @default.
- W2022861057 creator A5043741186 @default.
- W2022861057 creator A5058407840 @default.
- W2022861057 creator A5073726254 @default.
- W2022861057 creator A5090583347 @default.
- W2022861057 date "2012-08-01" @default.
- W2022861057 modified "2023-09-26" @default.
- W2022861057 title "Effects of flavonoids on CYP1 expression in RL95-2 endometrial carcinoma cells" @default.
- W2022861057 cites W1512670651 @default.
- W2022861057 cites W1561656160 @default.
- W2022861057 cites W1565276921 @default.
- W2022861057 cites W1917632018 @default.
- W2022861057 cites W1935479846 @default.
- W2022861057 cites W1964422998 @default.
- W2022861057 cites W1973524109 @default.
- W2022861057 cites W1977217437 @default.
- W2022861057 cites W1984799211 @default.
- W2022861057 cites W1990296956 @default.
- W2022861057 cites W1991056592 @default.
- W2022861057 cites W1991125347 @default.
- W2022861057 cites W1992026519 @default.
- W2022861057 cites W1993206880 @default.
- W2022861057 cites W1993375985 @default.
- W2022861057 cites W1996795806 @default.
- W2022861057 cites W2004932746 @default.
- W2022861057 cites W2005648074 @default.
- W2022861057 cites W2008478558 @default.
- W2022861057 cites W2013356649 @default.
- W2022861057 cites W2013502676 @default.
- W2022861057 cites W2025350394 @default.
- W2022861057 cites W2026322528 @default.
- W2022861057 cites W2027548206 @default.
- W2022861057 cites W2027671031 @default.
- W2022861057 cites W2029588268 @default.
- W2022861057 cites W2030559222 @default.
- W2022861057 cites W2042514640 @default.
- W2022861057 cites W2046978997 @default.
- W2022861057 cites W2049819085 @default.
- W2022861057 cites W2050456962 @default.
- W2022861057 cites W2052528439 @default.
- W2022861057 cites W2057240368 @default.
- W2022861057 cites W2069697813 @default.
- W2022861057 cites W2072103555 @default.
- W2022861057 cites W2074451871 @default.
- W2022861057 cites W2075780137 @default.
- W2022861057 cites W2078988238 @default.
- W2022861057 cites W2079648231 @default.
- W2022861057 cites W2080600450 @default.
- W2022861057 cites W2084965819 @default.
- W2022861057 cites W2087638306 @default.
- W2022861057 cites W2089229292 @default.
- W2022861057 cites W2089646327 @default.
- W2022861057 cites W2091070953 @default.
- W2022861057 cites W2098685834 @default.
- W2022861057 cites W2099433520 @default.
- W2022861057 cites W2102602516 @default.
- W2022861057 cites W2104794408 @default.
- W2022861057 cites W2107277218 @default.
- W2022861057 cites W2136147153 @default.
- W2022861057 cites W2141392884 @default.
- W2022861057 cites W2147980430 @default.
- W2022861057 cites W2159304791 @default.
- W2022861057 cites W2161233944 @default.
- W2022861057 cites W2221663590 @default.
- W2022861057 doi "https://doi.org/10.1016/j.foodchem.2012.02.002" @default.
- W2022861057 hasPublicationYear "2012" @default.
- W2022861057 type Work @default.
- W2022861057 sameAs 2022861057 @default.
- W2022861057 citedByCount "8" @default.
- W2022861057 countsByYear W20228610572012 @default.
- W2022861057 countsByYear W20228610572013 @default.
- W2022861057 countsByYear W20228610572014 @default.
- W2022861057 countsByYear W20228610572015 @default.
- W2022861057 countsByYear W20228610572016 @default.
- W2022861057 crossrefType "journal-article" @default.
- W2022861057 hasAuthorship W2022861057A5043741186 @default.
- W2022861057 hasAuthorship W2022861057A5058407840 @default.
- W2022861057 hasAuthorship W2022861057A5073726254 @default.
- W2022861057 hasAuthorship W2022861057A5090583347 @default.
- W2022861057 hasConcept C104317684 @default.
- W2022861057 hasConcept C155701950 @default.
- W2022861057 hasConcept C181199279 @default.
- W2022861057 hasConcept C185592680 @default.
- W2022861057 hasConcept C2225953 @default.
- W2022861057 hasConcept C2776268974 @default.
- W2022861057 hasConcept C2777810353 @default.
- W2022861057 hasConcept C2778004101 @default.
- W2022861057 hasConcept C2778173338 @default.
- W2022861057 hasConcept C2779054382 @default.
- W2022861057 hasConcept C2781263971 @default.
- W2022861057 hasConcept C526171541 @default.
- W2022861057 hasConcept C55493867 @default.
- W2022861057 hasConcept C86803240 @default.
- W2022861057 hasConcept C98274493 @default.
- W2022861057 hasConceptScore W2022861057C104317684 @default.
- W2022861057 hasConceptScore W2022861057C155701950 @default.
- W2022861057 hasConceptScore W2022861057C181199279 @default.