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- W2022861725 abstract "Results: Villin-Cre Sphk1flox/flox mice had significant higher colitis with longer segment of ulceration compared to Sphk1flox/flox mice (p 3mm were significantly decreased in villin-Cre Sphk1flox/flox Apcmin/+ mice compared with littermates. Histologic grade was more severe in Sphk1flox/flox Apcmin/+ mice compared with villin-Cre Sphk1flox/flox Apcmin/+ mice (invasive caricinoma, 71% vs 13%, p < 0.05). The expression of Sphk2 and the b-catenin target genes cyclin D1/c-myc were decreased in Sphk1-deficient tumors. The activities of b-catenin (nucleus), cyclin D1 and c-myc and were significantly decreased in villin-Cre Sphk1flox/flox Apcmin/+ mice compared with littermates in both IHC and Western blot analyses. In AOM/DSS CAC model, tumor number and size were not significantly different between Sphk1flox/flox and villin-Cre Sphk1flox/flox mice but there was a change of tumor size distribution between two groups. Conclusions: Epithelial deletion of Sphk1 inhibits CAC in Apcmin/+-DSS model in mice by the modulation of b-catenin and its target signal pathway." @default.
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- W2022861725 date "2014-02-01" @default.
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- W2022861725 title "DOP008 The absence of the Triggering Receptor Expressed on Myeloid Cells type-2 (TREM-2) induces a transmissible and protective intestinal microbiota for colitis and colitis associated cancer" @default.
- W2022861725 doi "https://doi.org/10.1016/s1873-9946(14)60033-7" @default.
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