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• W2022863426 abstract "In this research we studied the effect of interleukin-1 beta (IL-1 beta) on the cervix.Vaginal suppositories of a low dose of IL-1 beta (200 ng) were applied to non-pregnant and pregnant rabbits. Results were compared with a control group which were treated only by placebo. Water concentration, collagen content, collagenase and elastase activities were measured. Neutrophil numbers in the cervical connective tissue were counted. Also, interleukin-8 (IL-8) was measured in the supernatant of homogenized cervical tissue treated by IL-1 beta.Water contents of the tested cervices were increased (P < 0.006 and 0.03, respectively), whereas collagen content was markedly decreased (P < 0.0004 and 0.001, respectively). Collagenase activity was found to be increased in non-pregnant and pregnant cervices treated by IL-1 beta (P < 0.02 and 0.002, respectively). Also, elastase activity of these cervices were significantly increased compared to the control group (P < 0.0007 and 0.001, respectively). Neutrophil invasion was observed in the cervical connective tissues after application of IL-1 beta. IL-8 was significantly elevated (P < 0.0001) in the treated cervices.Interaction between IL-1 and IL-8 is suspected to be essential for cervical ripening." @default.
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• W2022863426 date "1995-05-01" @default.
• W2022863426 modified "2023-10-17" @default.
• W2022863426 title "The effect of interleukin-1 in rabbit cervical ripening" @default.
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• W2022863426 doi "https://doi.org/10.1016/0028-2243(95)02085-3" @default.
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