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- W2022864047 abstract "The mutagenicity of oxidized adenine, 2-hydroxyadenine (2-OH-Ade), was examined using an SV40 origin-dependent in vitro replication system with a HeLa extract. 2-OH-Ade was mutagenic with an induced mutation frequency of 0.03-0.8%. 2-OH-Ade mainly caused deletion and A→G mutations. These results indicate that 2-OH-Ade is mutagenic under in vitro replication conditions. The mutation spectrum of 2-hydroxy-dATP in in vitro replication, obtained in a previous study, is discussed." @default.
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- W2022864047 date "2006-01-01" @default.
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- W2022864047 title "Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract" @default.
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- W2022864047 doi "https://doi.org/10.3123/jemsge.28.92" @default.
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