FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022865527> ?p ?o ?g. }

• W2022865527 endingPage "212" @default.
• W2022865527 startingPage "205" @default.
• W2022865527 abstract "Adipocyte number, a determinant of adipose tissue mass, reflects the balance between the rates of proliferation/differentiation vs. apoptosis of preadipocytes. The percentage of 3T3-L1 preadipocytes undergoing cell death following serum deprivation was reduced by 10 nM insulin-like growth factor (IGF)-1 (from 50.0 +/- 0.7% for control starved cells to 27.5 +/- 3.1%). TUNEL staining confirmed the apoptotic nature of the cell death. The protective effect of IGF-1 was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin, and LY294002, but was unaffected by rapamycin, PD98059, or SB203580, which inhibit mammalian target of rapamycin (mTOR), ERK kinase (MEK1), and p38 MAPK respectively. Exogenous PI(3,4,5)P3 (10 microM), the principal product of IGF-1-stimulated PI3K in 3T3-L1 preadipocytes, had a modest survival effect on its own, reducing cell death from 47.9 +/- 3.4% to 35.6 +/- 3.5%. When added to the combination of IGF-1 and LY294002, PI(3,4,5)P3 reversed most of the inhibitory effect of LY294002 on IGF-1-dependent cell survival, protein kinase B/Akt phosphorylation, and caspase-3 activity. Taken together, these results implicate PI(3,4,5)P3 as a necessary signal for the anti-apoptotic action of IGF-1 on 3T3-L1 preadipocytes." @default.
• W2022865527 created "2016-06-24" @default.
• W2022865527 creator A5056252373 @default.
• W2022865527 creator A5080610661 @default.
• W2022865527 creator A5082979482 @default.
• W2022865527 creator A5083432878 @default.
• W2022865527 creator A5084271543 @default.
• W2022865527 date "2001-01-01" @default.
• W2022865527 modified "2023-09-27" @default.
• W2022865527 title "Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes**This work was supported by a grant (to A.S.) from the Medical Research Council of Canada." @default.
• W2022865527 cites W12631990 @default.
• W2022865527 cites W1490480018 @default.
• W2022865527 cites W1568605582 @default.
• W2022865527 cites W1791888878 @default.
• W2022865527 cites W1797700808 @default.
• W2022865527 cites W1969161473 @default.
• W2022865527 cites W1975290731 @default.
• W2022865527 cites W1989709491 @default.
• W2022865527 cites W1993836723 @default.
• W2022865527 cites W1993855694 @default.
• W2022865527 cites W1995757037 @default.
• W2022865527 cites W2002127663 @default.
• W2022865527 cites W2004205588 @default.
• W2022865527 cites W2013739995 @default.
• W2022865527 cites W2015449775 @default.
• W2022865527 cites W2020331673 @default.
• W2022865527 cites W2024306318 @default.
• W2022865527 cites W2028782957 @default.
• W2022865527 cites W2033801757 @default.
• W2022865527 cites W2037051425 @default.
• W2022865527 cites W2047826668 @default.
• W2022865527 cites W2050104368 @default.
• W2022865527 cites W2052816937 @default.
• W2022865527 cites W2056028922 @default.
• W2022865527 cites W2061046384 @default.
• W2022865527 cites W2066921963 @default.
• W2022865527 cites W2077321849 @default.
• W2022865527 cites W2079537922 @default.
• W2022865527 cites W2083308747 @default.
• W2022865527 cites W2085952650 @default.
• W2022865527 cites W2091915045 @default.
• W2022865527 cites W2093658838 @default.
• W2022865527 cites W2097767970 @default.
• W2022865527 cites W2100837269 @default.
• W2022865527 cites W2114291961 @default.
• W2022865527 cites W2116189789 @default.
• W2022865527 cites W2120662932 @default.
• W2022865527 cites W2147114673 @default.
• W2022865527 cites W2150264258 @default.
• W2022865527 cites W2155437852 @default.
• W2022865527 cites W2166833447 @default.
• W2022865527 cites W2167490100 @default.
• W2022865527 cites W2169260922 @default.
• W2022865527 cites W2321420381 @default.
• W2022865527 cites W2331405500 @default.
• W2022865527 cites W2346833085 @default.
• W2022865527 cites W81827842 @default.
• W2022865527 doi "https://doi.org/10.1210/endo.142.1.7902" @default.
• W2022865527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11145583" @default.
• W2022865527 hasPublicationYear "2001" @default.
• W2022865527 type Work @default.
• W2022865527 sameAs 2022865527 @default.
• W2022865527 citedByCount "40" @default.
• W2022865527 countsByYear W20228655272012 @default.
• W2022865527 countsByYear W20228655272013 @default.
• W2022865527 countsByYear W20228655272014 @default.
• W2022865527 countsByYear W20228655272015 @default.
• W2022865527 countsByYear W20228655272016 @default.
• W2022865527 countsByYear W20228655272020 @default.
• W2022865527 countsByYear W20228655272021 @default.
• W2022865527 countsByYear W20228655272022 @default.
• W2022865527 crossrefType "journal-article" @default.
• W2022865527 hasAuthorship W2022865527A5056252373 @default.
• W2022865527 hasAuthorship W2022865527A5080610661 @default.
• W2022865527 hasAuthorship W2022865527A5082979482 @default.
• W2022865527 hasAuthorship W2022865527A5083432878 @default.
• W2022865527 hasAuthorship W2022865527A5084271543 @default.
• W2022865527 hasBestOaLocation W20228655271 @default.
• W2022865527 hasConcept C126322002 @default.
• W2022865527 hasConcept C134018914 @default.
• W2022865527 hasConcept C142536801 @default.
• W2022865527 hasConcept C170493617 @default.
• W2022865527 hasConcept C171089720 @default.
• W2022865527 hasConcept C184235292 @default.
• W2022865527 hasConcept C190283241 @default.
• W2022865527 hasConcept C2775960820 @default.
• W2022865527 hasConcept C2776175234 @default.
• W2022865527 hasConcept C2776912716 @default.
• W2022865527 hasConcept C2778308172 @default.
• W2022865527 hasConcept C2780610907 @default.
• W2022865527 hasConcept C2780689927 @default.
• W2022865527 hasConcept C31573885 @default.
• W2022865527 hasConcept C55493867 @default.
• W2022865527 hasConcept C57074206 @default.
• W2022865527 hasConcept C62478195 @default.
• W2022865527 hasConcept C71924100 @default.
• W2022865527 hasConcept C75217442 @default.
• W2022865527 hasConcept C86554907 @default.

• next