Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022865852> ?p ?o ?g. }
- W2022865852 abstract "Nitric oxide (NO) generated by the reduction of sodium nitrite with sodium dithionite caused damage to plasmid Bluescript DNA leading to strand breaks and base modifications. The NO-plasmid DNA was highly immunogenic in rabbits. The antibody activity was inhibited to the extent of 86% with the immunogen as inhibitor, indicating the induction of immunogen specific antibodies. However, delineating the antigenic specificity of anti-NO-plasmid DNA antibodies by competition ELISA, multiple cross-reactivity was observed. The antibodies recognised B-, A- and allied conformations. The visual detection of immune complex formation with native and NO-plasmid DNA reiterated preferential binding with modified plasmid DNA. DNA modified by nitric oxide presents unique epitopes which may be one of the factors in antigen-driven autoimmune response in systemic lupus erythematosus." @default.
- W2022865852 created "2016-06-24" @default.
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- W2022865852 date "2001-09-01" @default.
- W2022865852 modified "2023-09-24" @default.
- W2022865852 title "Antigen binding characteristics of antibodies induced against nitric oxide modified plasmid DNA" @default.
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- W2022865852 doi "https://doi.org/10.1016/s0304-4165(01)00162-3" @default.
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