Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022867574> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2022867574 endingPage "373" @default.
- W2022867574 startingPage "368" @default.
- W2022867574 abstract "Abstract Objectives Olea europaea L. subsp. africana (Mill.) P.S. Green is widely used in South Africa by traditional medicine practitioners to treat diarrhoea. However, little is known scientifically about this South African species in the treatment of diarrhoea. The main aim of the study therefore was to investigate the antidiarrhoeal effect of the leaf methanol extract of the plant species in mice. Methods The antidiarrhoeal activity of the leaf methanol extract of O. europaea subsp. africana was studied using a castor oil-induced diarrhoeal test. The antipropulsive activity of the plant extract was also investigated using the charcoal meal transit test. Standard methods were used to investigate the acute toxicity and effect of O. europaea subsp. africana on castor oil-induced intraluminal fluid accumulation. Results Leaf methanol extract of O. europaea subsp. africana and loperamide, a standard antidiarrhoeal drug, significantly reduced the number of diarrhoeal episodes induced by castor oil, significantly decreased the stool mass, significantly delayed the onset of the diarrhoea and protected the animals against castor oil-induced diarrhoea. Both O. europaea subsp. africana and loperamide significantly decreased the gastrointestinal transit of charcoal meal and castor oil-induced intraluminal fluid accumulation in mice. The LD50 value was found to be 3475 mg/kg (p.o.). Conclusions The results obtained suggest that the leaf methanol extract of O. europaea subsp. africana has an antidiarrhoeal property and that, given orally, it may be non-toxic and/or safe in mice." @default.
- W2022867574 created "2016-06-24" @default.
- W2022867574 creator A5012148558 @default.
- W2022867574 creator A5063044187 @default.
- W2022867574 date "2010-03-01" @default.
- W2022867574 modified "2023-09-27" @default.
- W2022867574 title "Evaluation of the effects of <i>Olea europaea</i> L. subsp. africana (Mill.) P.S. Green (Oleaceae) leaf methanol extract against castor oil-induced diarrhoea in mice" @default.
- W2022867574 cites W1981220433 @default.
- W2022867574 cites W1994217478 @default.
- W2022867574 cites W2002433796 @default.
- W2022867574 cites W2023417128 @default.
- W2022867574 cites W2034448056 @default.
- W2022867574 cites W2042464319 @default.
- W2022867574 cites W2042464457 @default.
- W2022867574 cites W2045763309 @default.
- W2022867574 cites W2061229425 @default.
- W2022867574 doi "https://doi.org/10.1211/jpp.62.03.0012" @default.
- W2022867574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20487221" @default.
- W2022867574 hasPublicationYear "2010" @default.
- W2022867574 type Work @default.
- W2022867574 sameAs 2022867574 @default.
- W2022867574 citedByCount "11" @default.
- W2022867574 countsByYear W20228675742012 @default.
- W2022867574 countsByYear W20228675742013 @default.
- W2022867574 countsByYear W20228675742015 @default.
- W2022867574 countsByYear W20228675742017 @default.
- W2022867574 countsByYear W20228675742020 @default.
- W2022867574 countsByYear W20228675742022 @default.
- W2022867574 countsByYear W20228675742023 @default.
- W2022867574 crossrefType "journal-article" @default.
- W2022867574 hasAuthorship W2022867574A5012148558 @default.
- W2022867574 hasAuthorship W2022867574A5063044187 @default.
- W2022867574 hasBestOaLocation W20228675741 @default.
- W2022867574 hasConcept C2777573665 @default.
- W2022867574 hasConcept C2778229996 @default.
- W2022867574 hasConcept C2778814440 @default.
- W2022867574 hasConcept C2779802037 @default.
- W2022867574 hasConcept C2780007248 @default.
- W2022867574 hasConcept C2781397471 @default.
- W2022867574 hasConcept C55493867 @default.
- W2022867574 hasConcept C556039675 @default.
- W2022867574 hasConcept C59822182 @default.
- W2022867574 hasConcept C71924100 @default.
- W2022867574 hasConcept C86803240 @default.
- W2022867574 hasConcept C90924648 @default.
- W2022867574 hasConceptScore W2022867574C2777573665 @default.
- W2022867574 hasConceptScore W2022867574C2778229996 @default.
- W2022867574 hasConceptScore W2022867574C2778814440 @default.
- W2022867574 hasConceptScore W2022867574C2779802037 @default.
- W2022867574 hasConceptScore W2022867574C2780007248 @default.
- W2022867574 hasConceptScore W2022867574C2781397471 @default.
- W2022867574 hasConceptScore W2022867574C55493867 @default.
- W2022867574 hasConceptScore W2022867574C556039675 @default.
- W2022867574 hasConceptScore W2022867574C59822182 @default.
- W2022867574 hasConceptScore W2022867574C71924100 @default.
- W2022867574 hasConceptScore W2022867574C86803240 @default.
- W2022867574 hasConceptScore W2022867574C90924648 @default.
- W2022867574 hasIssue "3" @default.
- W2022867574 hasLocation W20228675741 @default.
- W2022867574 hasLocation W20228675742 @default.
- W2022867574 hasLocation W20228675743 @default.
- W2022867574 hasOpenAccess W2022867574 @default.
- W2022867574 hasPrimaryLocation W20228675741 @default.
- W2022867574 hasRelatedWork W1981612444 @default.
- W2022867574 hasRelatedWork W2022867574 @default.
- W2022867574 hasRelatedWork W2022973195 @default.
- W2022867574 hasRelatedWork W2052121277 @default.
- W2022867574 hasRelatedWork W2070546810 @default.
- W2022867574 hasRelatedWork W2183228850 @default.
- W2022867574 hasRelatedWork W2552092950 @default.
- W2022867574 hasRelatedWork W4238801355 @default.
- W2022867574 hasRelatedWork W4297675905 @default.
- W2022867574 hasRelatedWork W58409189 @default.
- W2022867574 hasVolume "62" @default.
- W2022867574 isParatext "false" @default.
- W2022867574 isRetracted "false" @default.
- W2022867574 magId "2022867574" @default.
- W2022867574 workType "article" @default.