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- W2022871382 abstract "A new test, called the ‘playground maze’, is described. Rat exploratory responses to a single novel object are measured in the context of responses to 7 familiar objects in a familiar environment. Responses are measured as time spent in areas around the objects on a circular open field. These times are expressed as percentages of the total time spent exploring all the objects and a value which is significantly greater than the expected chance level (12.5%) indicates a novelty response. The paths traversed by the animals on the maze are also recorded and the lengths of these give a measure of locomotion. Preliminary experiments on the effects of chlordiazepoxide (CDP) (1–5 mg/kg) and amphetamine (1.5–4 mg/kg) are reported. CDP significantly increased the novelty response but had no effect on locomotion. Amphetamine treatment at 4 mg/kg abolished the response to novel objects while lower doses (1.5 and 2 mg/kg) did not affect it. All 3 doses of amphetamine significantly increased locomotion. This test provides a new way of measuring the exploratory response to novelty under low stress conditions and allows the separation of drug effects on directed exploration and locomotion." @default.
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- W2022871382 date "1992-07-01" @default.
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- W2022871382 title "The playground maze: a new method for measuring directed exploration in the rat" @default.
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- W2022871382 doi "https://doi.org/10.1016/0165-0270(92)90026-a" @default.
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