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• W2022872025 abstract "Abstract Although human embryonic stem cell (hESC) hold therapeutic potential, teratoma formation has deterred clinical translation. Manganese (Mn 2+ ) enters metabolically active cells through voltage‐gated calcium channels and subsequently, induces T 1 shortening. We hypothesized that serial manganese‐enhanced MRI would have theranostic effect to assess hESC survival, teratoma formation, and hESC‐derived teratoma reduction through intracellular accumulation of Mn 2+ . Firefly luciferase transduced hESCs (hESC‐Lucs) were transplanted into severe combined immunodeficient mouse hindlimbs to form teratoma. The chemotherapy group was injected with MnCl 2 intraperitoneally three times a week. The control group was given MnCl 2 only prior to manganese‐enhanced MRI. Longitudinal evaluation by manganese‐enhanced MRI and bioluminescence imaging was performed. The chemotherapy group showed significant reduction in the teratoma volume and luciferase activity at weeks 6 and 8. Histology revealed increased proportion of dead cells and caspase 3 positive cells in the chemotherapy group. Systemic administration of MnCl 2 enabled simultaneous monitoring and elimination of hESC‐derived teratoma cells by higher intracellular accumulation of Mn 2+ . Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc." @default.
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• W2022872025 date "2011-12-21" @default.
• W2022872025 modified "2023-10-10" @default.
• W2022872025 title "Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma" @default.
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• W2022872025 doi "https://doi.org/10.1002/mrm.23262" @default.
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