FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022874530> ?p ?o ?g. }

• W2022874530 endingPage "444" @default.
• W2022874530 startingPage "437" @default.
• W2022874530 abstract "Corticotropin-releasing factor (CRF) is considered to be a main adrenocorticotropin-releasing factor in vertebrates. In non-mammalian species, CRF and related peptides cause the release of thyroid-stimulating hormone (TSH) from the anterior pituitary. The actions of CRF peptides are mediated by two G protein coupled receptors (CRF1 and CRF2) that have different ligand specificities. Using ligands that bind preferentially or selectively to the CRF2 we tested the hypothesis that TSH release by the amphibian pituitary gland is mediated by the CRF2. Injection of frog CRF, urocortin 1 or the CRF2-specific ligand urocortin 3 all produced significant, acute increases (by 2 h) in plasma thyroxine concentration in prometamorphic tadpoles. Chronic injections of CRF peptides accelerated tadpole metamorphosis, and the peptides with the highest affinity for the CRF2 (urocortin 1 and sauvagine) had the greatest potency. Ligands selective for the CRF2 (frog urocortin 3, mouse urocortins 2 and 3) all accelerated tadpole metamorphosis. We then tested frog urocortins 1 and 3, mouse urocortin 2 and sauvagine for their TSH-releasing activity using dispersed frog anterior pituitary cells in culture. All of the peptides tested markedly enhanced the release of TSH. Secretagogue-induced TSH release was completely blocked by the general CRF receptor antagonist astressin or the CRF2-specific antagonist antisauvagine-30. Conversely, the type 1 CRF receptor-specific antagonist antalarmin had no effect on TSH secretion. Our results support the hypothesis that CRF-induced TSH release by the amphibian pituitary gland is mediated by the CRF2." @default.
• W2022874530 created "2016-06-24" @default.
• W2022874530 creator A5013407142 @default.
• W2022874530 creator A5054371209 @default.
• W2022874530 creator A5067989882 @default.
• W2022874530 creator A5069642074 @default.
• W2022874530 creator A5077297035 @default.
• W2022874530 creator A5090112112 @default.
• W2022874530 date "2007-02-01" @default.
• W2022874530 modified "2023-10-11" @default.
• W2022874530 title "Involvement of the corticotropin-releasing factor (CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland" @default.
• W2022874530 cites W1487863689 @default.
• W2022874530 cites W1963677931 @default.
• W2022874530 cites W1968883430 @default.
• W2022874530 cites W1974381386 @default.
• W2022874530 cites W1983701838 @default.
• W2022874530 cites W1984282042 @default.
• W2022874530 cites W1989684809 @default.
• W2022874530 cites W1989918919 @default.
• W2022874530 cites W1990277797 @default.
• W2022874530 cites W1993512624 @default.
• W2022874530 cites W2001765569 @default.
• W2022874530 cites W2002508149 @default.
• W2022874530 cites W2006207326 @default.
• W2022874530 cites W2010503048 @default.
• W2022874530 cites W2021837980 @default.
• W2022874530 cites W2023169407 @default.
• W2022874530 cites W2024858299 @default.
• W2022874530 cites W2028710649 @default.
• W2022874530 cites W2033104894 @default.
• W2022874530 cites W2034584065 @default.
• W2022874530 cites W2036128032 @default.
• W2022874530 cites W2043662794 @default.
• W2022874530 cites W2044331640 @default.
• W2022874530 cites W2046013541 @default.
• W2022874530 cites W2048381373 @default.
• W2022874530 cites W2050477306 @default.
• W2022874530 cites W2052530157 @default.
• W2022874530 cites W2059692874 @default.
• W2022874530 cites W2065838029 @default.
• W2022874530 cites W2071818452 @default.
• W2022874530 cites W2085498925 @default.
• W2022874530 cites W2095036452 @default.
• W2022874530 cites W2095646540 @default.
• W2022874530 cites W2098918701 @default.
• W2022874530 cites W2120835858 @default.
• W2022874530 cites W2128570623 @default.
• W2022874530 cites W2148447743 @default.
• W2022874530 cites W2158871620 @default.
• W2022874530 cites W2162862956 @default.
• W2022874530 cites W4236983279 @default.
• W2022874530 cites W4249181252 @default.
• W2022874530 cites W4250902819 @default.
• W2022874530 cites W4251063968 @default.
• W2022874530 cites W4376848280 @default.
• W2022874530 doi "https://doi.org/10.1016/j.ygcen.2006.11.002" @default.
• W2022874530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17188689" @default.
• W2022874530 hasPublicationYear "2007" @default.
• W2022874530 type Work @default.
• W2022874530 sameAs 2022874530 @default.
• W2022874530 citedByCount "48" @default.
• W2022874530 countsByYear W20228745302013 @default.
• W2022874530 countsByYear W20228745302014 @default.
• W2022874530 countsByYear W20228745302015 @default.
• W2022874530 countsByYear W20228745302016 @default.
• W2022874530 countsByYear W20228745302017 @default.
• W2022874530 countsByYear W20228745302018 @default.
• W2022874530 countsByYear W20228745302019 @default.
• W2022874530 countsByYear W20228745302021 @default.
• W2022874530 countsByYear W20228745302022 @default.
• W2022874530 countsByYear W20228745302023 @default.
• W2022874530 crossrefType "journal-article" @default.
• W2022874530 hasAuthorship W2022874530A5013407142 @default.
• W2022874530 hasAuthorship W2022874530A5054371209 @default.
• W2022874530 hasAuthorship W2022874530A5067989882 @default.
• W2022874530 hasAuthorship W2022874530A5069642074 @default.
• W2022874530 hasAuthorship W2022874530A5077297035 @default.
• W2022874530 hasAuthorship W2022874530A5090112112 @default.
• W2022874530 hasConcept C126322002 @default.
• W2022874530 hasConcept C134018914 @default.
• W2022874530 hasConcept C170493617 @default.
• W2022874530 hasConcept C2776216936 @default.
• W2022874530 hasConcept C2776885963 @default.
• W2022874530 hasConcept C2777658017 @default.
• W2022874530 hasConcept C2777688879 @default.
• W2022874530 hasConcept C2779029589 @default.
• W2022874530 hasConcept C2780161494 @default.
• W2022874530 hasConcept C49039625 @default.
• W2022874530 hasConcept C71315377 @default.
• W2022874530 hasConcept C71924100 @default.
• W2022874530 hasConcept C86803240 @default.
• W2022874530 hasConceptScore W2022874530C126322002 @default.
• W2022874530 hasConceptScore W2022874530C134018914 @default.
• W2022874530 hasConceptScore W2022874530C170493617 @default.
• W2022874530 hasConceptScore W2022874530C2776216936 @default.
• W2022874530 hasConceptScore W2022874530C2776885963 @default.
• W2022874530 hasConceptScore W2022874530C2777658017 @default.
• W2022874530 hasConceptScore W2022874530C2777688879 @default.

• next