Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022876420> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2022876420 endingPage "55" @default.
- W2022876420 startingPage "49" @default.
- W2022876420 abstract "A series of n-alcohols and n-alkylthiols with carbon chains from 2 to 12 were examined for the inhibition of soybean lipoxygenase-1 (L-1). The alcohol produces a competitive inhibition, the extent of which increases with an increase in the carbon number of alkyl chain up to 8. Whereas the inhibition of the alkylthiol is noncompetitive, the extent of which is almost independent from the carbon number. From the behavior of pKi dependence on the carbon number of the alcohol, the decyl group appears to be optimum to bind to L-1. The thermodynamic analysis for the inhibition based upon van 't Hoff equation indicates positive enthalpy and entropy changes for the binding of the alcohol to the enzyme and negative enthalpy and positive to negative entropy changes for that of the alkylthiol. These observations suggest that the alcohol inhibits L-1 by binding of the hydrophobic alkyl tail to the catalytic site of the enzyme by a hydrophobic interaction. The alkylthiol inhibits by binding of the nucleophilic sulfhydryl head to a polarizable region of the enzyme and the alkyl tail to a hydrophobic region of the enzyme free from the steric hindrance as an anchor." @default.
- W2022876420 created "2016-06-24" @default.
- W2022876420 creator A5027879440 @default.
- W2022876420 creator A5069862344 @default.
- W2022876420 creator A5075164259 @default.
- W2022876420 creator A5091176815 @default.
- W2022876420 date "1992-04-01" @default.
- W2022876420 modified "2023-10-18" @default.
- W2022876420 title "Inhibition of soybean lipoxygenase-1 by n-alcohols and n-alkylthiols" @default.
- W2022876420 cites W132394417 @default.
- W2022876420 cites W1506442914 @default.
- W2022876420 cites W1589239098 @default.
- W2022876420 cites W192080578 @default.
- W2022876420 cites W1974337166 @default.
- W2022876420 cites W1978342320 @default.
- W2022876420 cites W1978968275 @default.
- W2022876420 cites W1989382417 @default.
- W2022876420 cites W2003306293 @default.
- W2022876420 cites W2011745680 @default.
- W2022876420 cites W2015784659 @default.
- W2022876420 cites W2030040673 @default.
- W2022876420 cites W2032790996 @default.
- W2022876420 cites W2038355634 @default.
- W2022876420 cites W2043885312 @default.
- W2022876420 cites W2047908599 @default.
- W2022876420 cites W2051260648 @default.
- W2022876420 cites W2075705506 @default.
- W2022876420 cites W2076704773 @default.
- W2022876420 cites W2082082651 @default.
- W2022876420 cites W2082731945 @default.
- W2022876420 cites W2097204946 @default.
- W2022876420 cites W2168191531 @default.
- W2022876420 cites W4256608107 @default.
- W2022876420 doi "https://doi.org/10.1016/0005-2760(92)90154-n" @default.
- W2022876420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1567907" @default.
- W2022876420 hasPublicationYear "1992" @default.
- W2022876420 type Work @default.
- W2022876420 sameAs 2022876420 @default.
- W2022876420 citedByCount "16" @default.
- W2022876420 countsByYear W20228764202014 @default.
- W2022876420 countsByYear W20228764202021 @default.
- W2022876420 crossrefType "journal-article" @default.
- W2022876420 hasAuthorship W2022876420A5027879440 @default.
- W2022876420 hasAuthorship W2022876420A5069862344 @default.
- W2022876420 hasAuthorship W2022876420A5075164259 @default.
- W2022876420 hasAuthorship W2022876420A5091176815 @default.
- W2022876420 hasConcept C121332964 @default.
- W2022876420 hasConcept C150757390 @default.
- W2022876420 hasConcept C155647269 @default.
- W2022876420 hasConcept C161790260 @default.
- W2022876420 hasConcept C178790620 @default.
- W2022876420 hasConcept C178907741 @default.
- W2022876420 hasConcept C181199279 @default.
- W2022876420 hasConcept C185592680 @default.
- W2022876420 hasConcept C201194858 @default.
- W2022876420 hasConcept C2780263894 @default.
- W2022876420 hasConcept C2780857362 @default.
- W2022876420 hasConcept C2781066024 @default.
- W2022876420 hasConcept C3288061 @default.
- W2022876420 hasConcept C71240020 @default.
- W2022876420 hasConcept C90260826 @default.
- W2022876420 hasConcept C97355855 @default.
- W2022876420 hasConceptScore W2022876420C121332964 @default.
- W2022876420 hasConceptScore W2022876420C150757390 @default.
- W2022876420 hasConceptScore W2022876420C155647269 @default.
- W2022876420 hasConceptScore W2022876420C161790260 @default.
- W2022876420 hasConceptScore W2022876420C178790620 @default.
- W2022876420 hasConceptScore W2022876420C178907741 @default.
- W2022876420 hasConceptScore W2022876420C181199279 @default.
- W2022876420 hasConceptScore W2022876420C185592680 @default.
- W2022876420 hasConceptScore W2022876420C201194858 @default.
- W2022876420 hasConceptScore W2022876420C2780263894 @default.
- W2022876420 hasConceptScore W2022876420C2780857362 @default.
- W2022876420 hasConceptScore W2022876420C2781066024 @default.
- W2022876420 hasConceptScore W2022876420C3288061 @default.
- W2022876420 hasConceptScore W2022876420C71240020 @default.
- W2022876420 hasConceptScore W2022876420C90260826 @default.
- W2022876420 hasConceptScore W2022876420C97355855 @default.
- W2022876420 hasIssue "1" @default.
- W2022876420 hasLocation W20228764201 @default.
- W2022876420 hasLocation W20228764202 @default.
- W2022876420 hasOpenAccess W2022876420 @default.
- W2022876420 hasPrimaryLocation W20228764201 @default.
- W2022876420 hasRelatedWork W1517688432 @default.
- W2022876420 hasRelatedWork W2010787206 @default.
- W2022876420 hasRelatedWork W2022876420 @default.
- W2022876420 hasRelatedWork W2032439797 @default.
- W2022876420 hasRelatedWork W2147427301 @default.
- W2022876420 hasRelatedWork W2317667020 @default.
- W2022876420 hasRelatedWork W2324898221 @default.
- W2022876420 hasRelatedWork W2949515063 @default.
- W2022876420 hasRelatedWork W2951317955 @default.
- W2022876420 hasRelatedWork W632982918 @default.
- W2022876420 hasVolume "1125" @default.
- W2022876420 isParatext "false" @default.
- W2022876420 isRetracted "false" @default.
- W2022876420 magId "2022876420" @default.
- W2022876420 workType "article" @default.