Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022877189> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022877189 endingPage "409" @default.
- W2022877189 startingPage "393" @default.
- W2022877189 abstract "Summary A simple, selective, and stability-indicating reverse phase liquid chromatographic method has been developed and validated for the simultaneous determination of impurities and forced degradation products of quetiapine fumarate. The chromatographic separation was achieved on Inertsil-3 C8, 150 mm × 4.6 mm, 5 μm column at 35°C with UV detection at 217 nm using gradient mobile phase at a flow rate of 1.0 mL/min. Mobile phase A contains a mixture of 0.01 M di-potassium hydrogen orthophosphate (pH 6.8) and acetonitrile in the ratio of 80:20 (v/v), respectively, and mobile phase B contains a mixture of 0.01 M di-potassium hydrogen orthophosphate (pH 6.8) and acetonitrile in the ratio of 20:80 (v/v), respectively. The drug product was subjected to the stress conditions of oxidative, hydrolysis (acid and base), hydrolytic, thermal, and photolytic degradation. Quetiapine fumarate was found to degrade significantly in acid, base, and oxidative stress conditions. The degradation products were well resolved from main peak and its impurities. The mass balance was found to be in the range of 96.6–102.2% in all the stressed conditions, thus proved the stability-indicating power of the method. The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of detection and quantification, accuracy, precision, and robustness." @default.
- W2022877189 created "2016-06-24" @default.
- W2022877189 creator A5019357792 @default.
- W2022877189 creator A5057221811 @default.
- W2022877189 creator A5059001607 @default.
- W2022877189 creator A5088402062 @default.
- W2022877189 date "2013-06-01" @default.
- W2022877189 modified "2023-09-26" @default.
- W2022877189 title "A validated stability-indicating RP-LC method for the estimation of process-related impurities and degradation products of quetiapine fumarate in solid oral dosage form" @default.
- W2022877189 cites W1966042227 @default.
- W2022877189 cites W1975714885 @default.
- W2022877189 cites W1980649173 @default.
- W2022877189 cites W1987940179 @default.
- W2022877189 cites W1997880277 @default.
- W2022877189 cites W2019879674 @default.
- W2022877189 cites W2025040248 @default.
- W2022877189 cites W2026318971 @default.
- W2022877189 cites W2033468374 @default.
- W2022877189 cites W2039936541 @default.
- W2022877189 cites W2040655825 @default.
- W2022877189 cites W2068704471 @default.
- W2022877189 cites W2073666900 @default.
- W2022877189 cites W2090148886 @default.
- W2022877189 cites W2142357474 @default.
- W2022877189 doi "https://doi.org/10.1556/achrom.25.2013.2.13" @default.
- W2022877189 hasPublicationYear "2013" @default.
- W2022877189 type Work @default.
- W2022877189 sameAs 2022877189 @default.
- W2022877189 citedByCount "11" @default.
- W2022877189 countsByYear W20228771892016 @default.
- W2022877189 countsByYear W20228771892018 @default.
- W2022877189 countsByYear W20228771892019 @default.
- W2022877189 countsByYear W20228771892020 @default.
- W2022877189 countsByYear W20228771892021 @default.
- W2022877189 countsByYear W20228771892022 @default.
- W2022877189 countsByYear W20228771892023 @default.
- W2022877189 crossrefType "journal-article" @default.
- W2022877189 hasAuthorship W2022877189A5019357792 @default.
- W2022877189 hasAuthorship W2022877189A5057221811 @default.
- W2022877189 hasAuthorship W2022877189A5059001607 @default.
- W2022877189 hasAuthorship W2022877189A5088402062 @default.
- W2022877189 hasBestOaLocation W20228771891 @default.
- W2022877189 hasConcept C178790620 @default.
- W2022877189 hasConcept C179998833 @default.
- W2022877189 hasConcept C185592680 @default.
- W2022877189 hasConcept C199360897 @default.
- W2022877189 hasConcept C2776412080 @default.
- W2022877189 hasConcept C2776921671 @default.
- W2022877189 hasConcept C2777682752 @default.
- W2022877189 hasConcept C2779679103 @default.
- W2022877189 hasConcept C2780494398 @default.
- W2022877189 hasConcept C2780634440 @default.
- W2022877189 hasConcept C2911140283 @default.
- W2022877189 hasConcept C41008148 @default.
- W2022877189 hasConcept C43617362 @default.
- W2022877189 hasConcept C45188465 @default.
- W2022877189 hasConcept C71987851 @default.
- W2022877189 hasConcept C76155785 @default.
- W2022877189 hasConcept C77281830 @default.
- W2022877189 hasConceptScore W2022877189C178790620 @default.
- W2022877189 hasConceptScore W2022877189C179998833 @default.
- W2022877189 hasConceptScore W2022877189C185592680 @default.
- W2022877189 hasConceptScore W2022877189C199360897 @default.
- W2022877189 hasConceptScore W2022877189C2776412080 @default.
- W2022877189 hasConceptScore W2022877189C2776921671 @default.
- W2022877189 hasConceptScore W2022877189C2777682752 @default.
- W2022877189 hasConceptScore W2022877189C2779679103 @default.
- W2022877189 hasConceptScore W2022877189C2780494398 @default.
- W2022877189 hasConceptScore W2022877189C2780634440 @default.
- W2022877189 hasConceptScore W2022877189C2911140283 @default.
- W2022877189 hasConceptScore W2022877189C41008148 @default.
- W2022877189 hasConceptScore W2022877189C43617362 @default.
- W2022877189 hasConceptScore W2022877189C45188465 @default.
- W2022877189 hasConceptScore W2022877189C71987851 @default.
- W2022877189 hasConceptScore W2022877189C76155785 @default.
- W2022877189 hasConceptScore W2022877189C77281830 @default.
- W2022877189 hasIssue "2" @default.
- W2022877189 hasLocation W20228771891 @default.
- W2022877189 hasOpenAccess W2022877189 @default.
- W2022877189 hasPrimaryLocation W20228771891 @default.
- W2022877189 hasRelatedWork W2008434336 @default.
- W2022877189 hasRelatedWork W2087046738 @default.
- W2022877189 hasRelatedWork W2089660391 @default.
- W2022877189 hasRelatedWork W2186574121 @default.
- W2022877189 hasRelatedWork W2262922897 @default.
- W2022877189 hasRelatedWork W2762211497 @default.
- W2022877189 hasRelatedWork W2909534107 @default.
- W2022877189 hasRelatedWork W2912248150 @default.
- W2022877189 hasRelatedWork W3210559715 @default.
- W2022877189 hasRelatedWork W2185489241 @default.
- W2022877189 hasVolume "25" @default.
- W2022877189 isParatext "false" @default.
- W2022877189 isRetracted "false" @default.
- W2022877189 magId "2022877189" @default.
- W2022877189 workType "article" @default.