FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022878030> ?p ?o ?g. }

• W2022878030 abstract "Serotonin (5-hydroxytryptamine, 5-HT) is involved in gastrointestinal tract (GIT) motor functions through binding to specific receptors located in the GIT walls. The objectives of the current study were to compare mRNA levels and binding sites of 5-HT(4) receptors (5-HTR(4)) in smooth muscle layers from the fundus abomasi, pylorus, ileum, cecum, proximal loop of the ascending colon (PLAC), and external loop of the spiral colon (ELSC) of healthy dairy cows, and to verify whether mRNA and protein expression were correlated. Smooth muscle samples were prepared by scraping the mucosa and submucosa from full-thickness intestinal wall samples. The mRNA levels of 5-HTR(4) were measured by real-time PCR and expressed relative to those of the housekeeping gene glyceraldehyde phosphate dehydrogenase. Binding studies were performed using the 5-HTR(4) antagonist [(3)H]GR113808. The mRNA levels of 5-HTR(4) were affected (P < 0.05) by location along the GIT. The mRNA levels of 5-HTR(4) in the ELSC and the ileum were greater than in the PLAC (P = 0.05 and P = 0.07, respectively) but similar to those of all other locations. The competitive binding of [(3)H]GR113808 to suspended membranes from the fundus abomasi, pylorus, cecum, and ELSC was best fit by a 2-site receptor model, whereas it was best fit by a 1-site receptor model in the ileum and PLAC. The mRNA levels and numbers of 5-HTR(4) were not correlated (r = 0.14; P = 0.71). In conclusion, mRNA and binding sites for 5-HTR(4) are present in the smooth muscle layer of the entire GIT of dairy cows and may play a role with respect to motility. The effects of activation of this receptor subtype may be different among GIT locations due to differences in the amount of high- relative to low-affinity binding sites." @default.
• W2022878030 created "2016-06-24" @default.
• W2022878030 creator A5011415508 @default.
• W2022878030 creator A5021442572 @default.
• W2022878030 creator A5065105050 @default.
• W2022878030 creator A5086762528 @default.
• W2022878030 date "2006-12-01" @default.
• W2022878030 modified "2023-09-28" @default.
• W2022878030 title "5-Hydroxytryptamine-4 receptor messenger ribonucleic acid levels and densities in gastrointestinal muscle layers from healthy dairy cows1" @default.
• W2022878030 cites W1481686455 @default.
• W2022878030 cites W1975661708 @default.
• W2022878030 cites W1979067492 @default.
• W2022878030 cites W1979477079 @default.
• W2022878030 cites W1990029228 @default.
• W2022878030 cites W1995838863 @default.
• W2022878030 cites W2001743819 @default.
• W2022878030 cites W2004522200 @default.
• W2022878030 cites W2005490869 @default.
• W2022878030 cites W2014106658 @default.
• W2022878030 cites W2015634759 @default.
• W2022878030 cites W2020242827 @default.
• W2022878030 cites W2022872850 @default.
• W2022878030 cites W2024964650 @default.
• W2022878030 cites W2026703453 @default.
• W2022878030 cites W2037550602 @default.
• W2022878030 cites W2039806397 @default.
• W2022878030 cites W2043972017 @default.
• W2022878030 cites W2045952471 @default.
• W2022878030 cites W2053074524 @default.
• W2022878030 cites W2060598688 @default.
• W2022878030 cites W2065113227 @default.
• W2022878030 cites W2074631079 @default.
• W2022878030 cites W2075704954 @default.
• W2022878030 cites W2076079712 @default.
• W2022878030 cites W2076438268 @default.
• W2022878030 cites W2079358834 @default.
• W2022878030 cites W2086844446 @default.
• W2022878030 cites W2116051875 @default.
• W2022878030 cites W2118152671 @default.
• W2022878030 cites W214870122 @default.
• W2022878030 cites W2154811900 @default.
• W2022878030 cites W263254279 @default.
• W2022878030 cites W67730575 @default.
• W2022878030 doi "https://doi.org/10.2527/jas.2006-228" @default.
• W2022878030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17093220" @default.
• W2022878030 hasPublicationYear "2006" @default.
• W2022878030 type Work @default.
• W2022878030 sameAs 2022878030 @default.
• W2022878030 citedByCount "6" @default.
• W2022878030 countsByYear W20228780302012 @default.
• W2022878030 countsByYear W20228780302018 @default.
• W2022878030 crossrefType "journal-article" @default.
• W2022878030 hasAuthorship W2022878030A5011415508 @default.
• W2022878030 hasAuthorship W2022878030A5021442572 @default.
• W2022878030 hasAuthorship W2022878030A5065105050 @default.
• W2022878030 hasAuthorship W2022878030A5086762528 @default.
• W2022878030 hasConcept C104317684 @default.
• W2022878030 hasConcept C105580179 @default.
• W2022878030 hasConcept C126322002 @default.
• W2022878030 hasConcept C134018914 @default.
• W2022878030 hasConcept C153911025 @default.
• W2022878030 hasConcept C170493617 @default.
• W2022878030 hasConcept C185592680 @default.
• W2022878030 hasConcept C2777226302 @default.
• W2022878030 hasConcept C2777507495 @default.
• W2022878030 hasConcept C2778012502 @default.
• W2022878030 hasConcept C2779422922 @default.
• W2022878030 hasConcept C2780512811 @default.
• W2022878030 hasConcept C2780833581 @default.
• W2022878030 hasConcept C55493867 @default.
• W2022878030 hasConcept C71924100 @default.
• W2022878030 hasConcept C86803240 @default.
• W2022878030 hasConceptScore W2022878030C104317684 @default.
• W2022878030 hasConceptScore W2022878030C105580179 @default.
• W2022878030 hasConceptScore W2022878030C126322002 @default.
• W2022878030 hasConceptScore W2022878030C134018914 @default.
• W2022878030 hasConceptScore W2022878030C153911025 @default.
• W2022878030 hasConceptScore W2022878030C170493617 @default.
• W2022878030 hasConceptScore W2022878030C185592680 @default.
• W2022878030 hasConceptScore W2022878030C2777226302 @default.
• W2022878030 hasConceptScore W2022878030C2777507495 @default.
• W2022878030 hasConceptScore W2022878030C2778012502 @default.
• W2022878030 hasConceptScore W2022878030C2779422922 @default.
• W2022878030 hasConceptScore W2022878030C2780512811 @default.
• W2022878030 hasConceptScore W2022878030C2780833581 @default.
• W2022878030 hasConceptScore W2022878030C55493867 @default.
• W2022878030 hasConceptScore W2022878030C71924100 @default.
• W2022878030 hasConceptScore W2022878030C86803240 @default.
• W2022878030 hasLocation W20228780301 @default.
• W2022878030 hasLocation W20228780302 @default.
• W2022878030 hasOpenAccess W2022878030 @default.
• W2022878030 hasPrimaryLocation W20228780301 @default.
• W2022878030 hasRelatedWork W1972736016 @default.
• W2022878030 hasRelatedWork W2022878030 @default.
• W2022878030 hasRelatedWork W2034583712 @default.
• W2022878030 hasRelatedWork W2091734559 @default.
• W2022878030 hasRelatedWork W2169225653 @default.
• W2022878030 hasRelatedWork W2276244880 @default.
• W2022878030 hasRelatedWork W2416931975 @default.
• W2022878030 hasRelatedWork W2417334586 @default.

• next