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- W2022878847 abstract "RATIONALE: Eosinophilic bronchitis (EB) is characterized by chronic cough and sputum eosinophilia without bronchial hyperresponsiveness. Patients with EB show increased levels of prostaglandin E2 (PGE2) in sputum supernatant compared with asthmatic subjects. PGE2 could play a protective role in this disorder. METHODS: Twenty-one patients with EB, 16 asthmatic patients and 12 healthy subjects were studied. We analyzed PGE2 receptors (EP2 and EP4) by Real-Time PCR from peripheral blood eosinophils, induced sputum and bronchial biopsies. Also, receptor expression was analyzed by confocal microscopy and flow cytometry in peripheral blood eosinophils. Moreover, we tested the effect of sputum supernatants from EB and asthmatic patients on bronchial smooth muscle cells (BSMC) proliferation. RESULTS: Patients with EB showed higher mRNA expression levels of EP2 and EP4 than asthmatic patients in peripheral blood eosinophils (7.78 and 10.86-fold), in sputum cells (2.02 and 1.36-fold) and in bronchial biopsies (1.85 and 2.38-fold). Also, an elevated expression of EP2 and EP4 in eosinophils of EB patients with respect to asthmatic patients was observed by flow cytometry. When BSMC were cultured with EB sputum supernatants an important inhibition of BSMC proliferation was observed when compared with asthmatic sputum supernatants (60.33% vs 48.92%; p<0.05). CONCLUSIONS: The protective role of PGE2 in eosinophilic bronchitis is probably exerted through EP2 and EP4. PGE2 inhibits BSMC proliferation entailing a reduction of smooth muscle hyperplasia and preventing airflow obstruction. These results may open novel therapeutic approaches to inflammatory respiratory diseases." @default.
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- W2022878847 date "2010-02-01" @default.
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- W2022878847 title "PGE2 May Decrease Airway Inflammation and Muscular Hyperplasia in Eosinophilic Bronchitis Patients through Prostanoid Receptors EP2 and EP4" @default.
- W2022878847 doi "https://doi.org/10.1016/j.jaci.2009.12.204" @default.
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