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- W2022878861 abstract "A dispersed family of repetitive DNA sequences that is amplified in Old World primates has been characterized. The sequences are present in about 250–350 copies in humans, found on all chromosomes, and some are at least 1 kb in size. Within the core repeat is a 178-bp region that is moderately-to-highly conserved. A representative sequence exhibited strong promoter activity when placed in front of a promoterless gene and transfected into human cells. This promoter activity has been localized to a 138-bp region of the repeat that is about 150 bp downstream of the 178-bp conserved region. Transcripts of the sequences were not detected in six human breast epithelial and teratocarcinoma cell lines. Based upon the work of Pavelitz et al. [Pavelitz, T., Rusche, L., Matera, A.G., Scharf, J.M., Weiner, A.M., 1995. EMBO J. 14, 169–177], the sequence appears to be related to the LTR of an HERV-K class human endogenous retrovirus." @default.
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- W2022878861 date "1997-10-01" @default.
- W2022878861 modified "2023-10-16" @default.
- W2022878861 title "A family of repetitive DNA sequences in Old World primates" @default.
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- W2022878861 doi "https://doi.org/10.1016/s0378-1119(97)00381-8" @default.
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