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- W2022880095 abstract "1 Arousal from sleep is associated with transient stimulation of ventilation above normal waking levels that predisposes to subsequent breathing instability and central apnoea. The transient hyperpnoea at arousal is normally explained by differences in arterial partial pressure of CO2 (P a,CO 2 ) between sleep and wakefulness, with a higher P a,CO 2 in sleep leading to stimulation of ventilation at arousal according to the awake ventilatory response to CO2. Surprisingly, however, the validity of this current model in fully explaining the increased ventilation at arousal from sleep has not been directly tested. 2 This study tests the hypothesis that the level of ventilation at arousal from non-rapid eye movement (non-REM) sleep is greater than that produced by elevating P a,CO 2 in wakefulness to the sleeping level, i.e. the ventilation predicted by the current model. 3 Studies were performed in five dogs. Inspired CO2 was used to increase end-tidal partial pressure of CO2 (P ET,CO 2 ) in wakefulness and measure the ventilatory response. The same P ET,CO 2 was then maintained in non-REM sleep. Ventilation was measured for 10 breaths before and after arousal from non-REM sleep induced by a 72 dB tone. 4 Arousal from sleep produced a transient surge in ventilation of 1.42 ± 0.35 l min−1 (P= 0.005). This increased ventilation was due to arousal from sleep per se as the tone alone produced no change in awake ventilation. In support of the hypothesis, ventilation at wake onset from sleep was greater by 0.83 ± 0.28 l min−1 (P= 0.031) than the ventilation elicited in wakefulness by raising P ET,CO 2 to the sleeping level. 5 The results show that > 50% of the increase in ventilation at wake onset from sleep is not attributable to the awake ventilatory response to the elevated P a,CO 2 that was previously present in sleep. This result leads to important modifications of the physiological model currently used to explain the ventilatory consequences of arousal from sleep." @default.
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- W2022880095 date "2001-08-01" @default.
- W2022880095 modified "2023-10-18" @default.
- W2022880095 title "The ventilatory response to arousal from sleep is not fully explained by differences in CO<sub>2</sub> levels between sleep and wakefulness" @default.
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- W2022880095 doi "https://doi.org/10.1111/j.1469-7793.2001.00881.x" @default.
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