FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022881117> ?p ?o ?g. }

• W2022881117 endingPage "104" @default.
• W2022881117 startingPage "99" @default.
• W2022881117 abstract "Axonal transport of neurotransmitter receptors is a well established phenomenon. In this study, we sought to determine whether the cellular components necessary for mechanical-to-electrical transduction in primary afferents are also conveyed to the peripheral terminals via fast axonal transport. In previous studies, severed cutaneous nerves have been shown to develop mechanical sensitivity at their ligated ends within hours of injury. Since the rate of development of this mechanical sensitivity was temperature dependent, we postulated that axonal transport was involved. In this study, we performed two experiments in which the rate of axonal transport was modified. In the first experiment, the nerve was cut at a proximal site to block the supply of additional transported components to the distal end of the nerve. At a point 80 to 120 mm distal to this proximal cut, a nerve crush and ligation were performed either 3 or 12 h after the proximal nerve ligation. The centripetally conducted action potentials generated by applying mechanical stimuli to the nerve subjacent to the distal ligature were recorded 10 h after the distal ligature was placed. Given a fast axonal transport rate of 400 mm/day, transported molecules should traverse a 100-mm segment within 6 h. Consistent with this calculation, 29% of the myelinated fibers responded to mechanical stimuli when the time lapse between lesions was 3 h, whereas only 3% responded when the time between lesions was 12 h. In the second experiment, axonal transport was enhanced by a prior nerve injury (conditioning lesion). Seven days after this lesion, the nerve was reinjured proximal to the conditioning lesion location, and the development of mechanosensitivity at the acute injury site was assessed. The rate of development of mechanical sensitivity was greatly enhanced by the conditioning lesion, and 44% of the myelinated fibers responded to mechanical stimuli 10 h after the acute injury. These two studies support the ideas that: (1) the cellular components necessary for mechanical-to-electrical transduction are transported to distal sensory terminals via fast axonal transport; (2) nerve crush and ligation lead to ectopic expression of these transducers at the nerve injury site; and (3) prior nerve injury increases the rate of development of mechanosensitivity, perhaps by increasing the production of transducers." @default.
• W2022881117 created "2016-06-24" @default.
• W2022881117 creator A5007640041 @default.
• W2022881117 creator A5026711216 @default.
• W2022881117 creator A5086565001 @default.
• W2022881117 date "1994-03-01" @default.
• W2022881117 modified "2023-09-26" @default.
• W2022881117 title "Cellular components necessary for mechanoelectrical transduction are conveyed to primary afferent terminals by fast axonal transport" @default.
• W2022881117 cites W124369364 @default.
• W2022881117 cites W1973071194 @default.
• W2022881117 cites W1981562838 @default.
• W2022881117 cites W1982732253 @default.
• W2022881117 cites W1987512190 @default.
• W2022881117 cites W1993765535 @default.
• W2022881117 cites W2018703337 @default.
• W2022881117 cites W2029376214 @default.
• W2022881117 cites W2047974869 @default.
• W2022881117 cites W2075472925 @default.
• W2022881117 cites W2081533056 @default.
• W2022881117 cites W2166282511 @default.
• W2022881117 cites W2266267593 @default.
• W2022881117 cites W2343201735 @default.
• W2022881117 cites W2398731712 @default.
• W2022881117 cites W2409694852 @default.
• W2022881117 doi "https://doi.org/10.1016/0006-8993(94)91820-1" @default.
• W2022881117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8019856" @default.
• W2022881117 hasPublicationYear "1994" @default.
• W2022881117 type Work @default.
• W2022881117 sameAs 2022881117 @default.
• W2022881117 citedByCount "39" @default.
• W2022881117 countsByYear W20228811172013 @default.
• W2022881117 countsByYear W20228811172014 @default.
• W2022881117 countsByYear W20228811172018 @default.
• W2022881117 countsByYear W20228811172020 @default.
• W2022881117 countsByYear W20228811172021 @default.
• W2022881117 crossrefType "journal-article" @default.
• W2022881117 hasAuthorship W2022881117A5007640041 @default.
• W2022881117 hasAuthorship W2022881117A5026711216 @default.
• W2022881117 hasAuthorship W2022881117A5086565001 @default.
• W2022881117 hasConcept C105702510 @default.
• W2022881117 hasConcept C126322002 @default.
• W2022881117 hasConcept C136357698 @default.
• W2022881117 hasConcept C142724271 @default.
• W2022881117 hasConcept C15152581 @default.
• W2022881117 hasConcept C169760540 @default.
• W2022881117 hasConcept C179437574 @default.
• W2022881117 hasConcept C185592680 @default.
• W2022881117 hasConcept C2775991916 @default.
• W2022881117 hasConcept C2777998629 @default.
• W2022881117 hasConcept C2779530196 @default.
• W2022881117 hasConcept C2781156865 @default.
• W2022881117 hasConcept C55493867 @default.
• W2022881117 hasConcept C70192387 @default.
• W2022881117 hasConcept C71924100 @default.
• W2022881117 hasConcept C86803240 @default.
• W2022881117 hasConceptScore W2022881117C105702510 @default.
• W2022881117 hasConceptScore W2022881117C126322002 @default.
• W2022881117 hasConceptScore W2022881117C136357698 @default.
• W2022881117 hasConceptScore W2022881117C142724271 @default.
• W2022881117 hasConceptScore W2022881117C15152581 @default.
• W2022881117 hasConceptScore W2022881117C169760540 @default.
• W2022881117 hasConceptScore W2022881117C179437574 @default.
• W2022881117 hasConceptScore W2022881117C185592680 @default.
• W2022881117 hasConceptScore W2022881117C2775991916 @default.
• W2022881117 hasConceptScore W2022881117C2777998629 @default.
• W2022881117 hasConceptScore W2022881117C2779530196 @default.
• W2022881117 hasConceptScore W2022881117C2781156865 @default.
• W2022881117 hasConceptScore W2022881117C55493867 @default.
• W2022881117 hasConceptScore W2022881117C70192387 @default.
• W2022881117 hasConceptScore W2022881117C71924100 @default.
• W2022881117 hasConceptScore W2022881117C86803240 @default.
• W2022881117 hasIssue "1" @default.
• W2022881117 hasLocation W20228811171 @default.
• W2022881117 hasLocation W20228811172 @default.
• W2022881117 hasOpenAccess W2022881117 @default.
• W2022881117 hasPrimaryLocation W20228811171 @default.
• W2022881117 hasRelatedWork W1990124435 @default.
• W2022881117 hasRelatedWork W2016362698 @default.
• W2022881117 hasRelatedWork W2019296074 @default.
• W2022881117 hasRelatedWork W2022881117 @default.
• W2022881117 hasRelatedWork W2023095885 @default.
• W2022881117 hasRelatedWork W2045374533 @default.
• W2022881117 hasRelatedWork W2126118258 @default.
• W2022881117 hasRelatedWork W2489753988 @default.
• W2022881117 hasRelatedWork W2968479970 @default.
• W2022881117 hasRelatedWork W167631596 @default.
• W2022881117 hasVolume "641" @default.
• W2022881117 isParatext "false" @default.
• W2022881117 isRetracted "false" @default.
• W2022881117 magId "2022881117" @default.
• W2022881117 workType "article" @default.