Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022882907> ?p ?o ?g. }
- W2022882907 endingPage "e73650" @default.
- W2022882907 startingPage "e73650" @default.
- W2022882907 abstract "Tumor-specific adenoviral vectors comprise a fruitful gene-based diagnostic imaging and therapy research area for advanced stage of cancer, including metastatic disease. However, clinical translation of viral vectors has encountered considerable obstacles, largely due to host immune responses against the virus. Here, we explored the utilization of an immunosuppressant, rapamycin, to circumvent the anti-adenovirus immunity in immunocompetent murine prostate cancer models. Rapamycin diminished adenoviral-induced acute immune response by inhibiting NF-κB activation; it also reduced the scale and delayed the onset of inflammatory cytokine secretion. Further, we found that rapamycin abrogated anti-adenovirus antibody production and retarded the function of myeloid cells and lymphocytes that were activated upon viral administration in pre-immunized hosts. Thus, the co-administration of rapamycin prolonged and enhanced adenovirus-delivered transgene expression in vivo, and thereby augmented the imaging capability of adenoviral vectors in both bioluminescent and positron emission tomography modalities. Furthermore, we showed that despite an excellent response of cancer cells to a cytotoxic gene therapeutic vector in vitro, only minimal therapeutic effects were observed in vivo in pre-immunized mice. However, when we combined gene therapy with transient immunosuppression, complete tumor growth arrest was achieved. Overall, transient immunosuppression by rapamycin was able to boost the diagnostic utility and therapeutic potentials of adenoviral vectors." @default.
- W2022882907 created "2016-06-24" @default.
- W2022882907 creator A5000354865 @default.
- W2022882907 creator A5032257695 @default.
- W2022882907 creator A5054396700 @default.
- W2022882907 creator A5083611896 @default.
- W2022882907 creator A5084229628 @default.
- W2022882907 creator A5091002191 @default.
- W2022882907 date "2013-09-02" @default.
- W2022882907 modified "2023-09-26" @default.
- W2022882907 title "Rapamycin Enhances Adenovirus-Mediated Cancer Imaging and Therapy in Pre-Immunized Murine Hosts" @default.
- W2022882907 cites W1496352515 @default.
- W2022882907 cites W1621753546 @default.
- W2022882907 cites W1623305982 @default.
- W2022882907 cites W1624279568 @default.
- W2022882907 cites W1676309931 @default.
- W2022882907 cites W1946263079 @default.
- W2022882907 cites W1966037150 @default.
- W2022882907 cites W1967033604 @default.
- W2022882907 cites W1974600730 @default.
- W2022882907 cites W1979341492 @default.
- W2022882907 cites W1979980796 @default.
- W2022882907 cites W1980720313 @default.
- W2022882907 cites W1988050497 @default.
- W2022882907 cites W1991171011 @default.
- W2022882907 cites W1992033402 @default.
- W2022882907 cites W1992727359 @default.
- W2022882907 cites W1993742546 @default.
- W2022882907 cites W1995466259 @default.
- W2022882907 cites W1998397400 @default.
- W2022882907 cites W2008621673 @default.
- W2022882907 cites W2017961829 @default.
- W2022882907 cites W2020364299 @default.
- W2022882907 cites W2022850278 @default.
- W2022882907 cites W2024608158 @default.
- W2022882907 cites W2032396826 @default.
- W2022882907 cites W2042841596 @default.
- W2022882907 cites W2044708576 @default.
- W2022882907 cites W2045430045 @default.
- W2022882907 cites W2054287302 @default.
- W2022882907 cites W2054545020 @default.
- W2022882907 cites W2056680264 @default.
- W2022882907 cites W2061448062 @default.
- W2022882907 cites W2076060547 @default.
- W2022882907 cites W2080329545 @default.
- W2022882907 cites W2081655601 @default.
- W2022882907 cites W2086651005 @default.
- W2022882907 cites W2087466782 @default.
- W2022882907 cites W2090648684 @default.
- W2022882907 cites W2095109478 @default.
- W2022882907 cites W2100353497 @default.
- W2022882907 cites W2104045882 @default.
- W2022882907 cites W2109065342 @default.
- W2022882907 cites W2110402196 @default.
- W2022882907 cites W2122033091 @default.
- W2022882907 cites W2122158568 @default.
- W2022882907 cites W2132101222 @default.
- W2022882907 cites W2144584725 @default.
- W2022882907 cites W2156829792 @default.
- W2022882907 cites W2158156023 @default.
- W2022882907 cites W2159936534 @default.
- W2022882907 cites W2161828364 @default.
- W2022882907 cites W2164942212 @default.
- W2022882907 cites W2166470661 @default.
- W2022882907 cites W2169503293 @default.
- W2022882907 cites W2175655302 @default.
- W2022882907 doi "https://doi.org/10.1371/journal.pone.0073650" @default.
- W2022882907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3759448" @default.
- W2022882907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24023896" @default.
- W2022882907 hasPublicationYear "2013" @default.
- W2022882907 type Work @default.
- W2022882907 sameAs 2022882907 @default.
- W2022882907 citedByCount "3" @default.
- W2022882907 countsByYear W20228829072014 @default.
- W2022882907 countsByYear W20228829072016 @default.
- W2022882907 countsByYear W20228829072022 @default.
- W2022882907 crossrefType "journal-article" @default.
- W2022882907 hasAuthorship W2022882907A5000354865 @default.
- W2022882907 hasAuthorship W2022882907A5032257695 @default.
- W2022882907 hasAuthorship W2022882907A5054396700 @default.
- W2022882907 hasAuthorship W2022882907A5083611896 @default.
- W2022882907 hasAuthorship W2022882907A5084229628 @default.
- W2022882907 hasAuthorship W2022882907A5091002191 @default.
- W2022882907 hasBestOaLocation W20228829071 @default.
- W2022882907 hasConcept C102230213 @default.
- W2022882907 hasConcept C104317684 @default.
- W2022882907 hasConcept C111335760 @default.
- W2022882907 hasConcept C111599444 @default.
- W2022882907 hasConcept C121608353 @default.
- W2022882907 hasConcept C126322002 @default.
- W2022882907 hasConcept C150903083 @default.
- W2022882907 hasConcept C161997846 @default.
- W2022882907 hasConcept C203014093 @default.
- W2022882907 hasConcept C207001950 @default.
- W2022882907 hasConcept C2776954459 @default.
- W2022882907 hasConcept C2780252810 @default.
- W2022882907 hasConcept C32470452 @default.
- W2022882907 hasConcept C40767141 @default.