Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022883506> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2022883506 endingPage "129" @default.
- W2022883506 startingPage "128" @default.
- W2022883506 abstract "The action of retinoic acid (RA) in normal development and differentiation is mediated by changes in the expression of RA-responsive target genes. We used differential display reverse transcriptase polymerase chain reaction (RT-PCR) to identify RA-responsive genes expressed in embryonic stem (ES) cells and found that murine folate receptor-α (FR-α) expression is rapidly induced by RA treatment. The observed increase in FR-α expression occurs within 3 h, is independent of protein synthesis and does not occur when ES cells are differentiated by removal of leukaemia inhibitory factor (LIF), evidence that the response to RA is both direct and specific. Two messenger RNA (mRNA) isoforms of FR-α featuring novel sequence in the 5′ untranslated region (UTR) were cloned, and both were found to be upregulated by RA. Other splice variants in both the 5′ UTR and 3′ UTR of FR-α mRNA were also identified. There is a striking similarity between these splicing patterns and those reported for human FR-α, which also generates multiple isoforms by alternative splicing in the 5′ and 3′ UTR. The conservation of these splicing patterns in the non-coding regions of the FR-α gene between mouse and human suggests that these regions, and in particular the 5′ UTR, play an important role in regulating expression of this gene." @default.
- W2022883506 created "2016-06-24" @default.
- W2022883506 creator A5001175535 @default.
- W2022883506 creator A5019940528 @default.
- W2022883506 creator A5033389759 @default.
- W2022883506 creator A5082294371 @default.
- W2022883506 creator A5089305017 @default.
- W2022883506 date "2006-11-01" @default.
- W2022883506 modified "2023-09-27" @default.
- W2022883506 title "420 POSTER Measuring alpha-folate receptor expression levels on ascites tumour cells may help to identify patients that are more likely to respond to alpha-FR targeted therapy" @default.
- W2022883506 doi "https://doi.org/10.1016/s1359-6349(06)70425-6" @default.
- W2022883506 hasPublicationYear "2006" @default.
- W2022883506 type Work @default.
- W2022883506 sameAs 2022883506 @default.
- W2022883506 citedByCount "0" @default.
- W2022883506 crossrefType "journal-article" @default.
- W2022883506 hasAuthorship W2022883506A5001175535 @default.
- W2022883506 hasAuthorship W2022883506A5019940528 @default.
- W2022883506 hasAuthorship W2022883506A5033389759 @default.
- W2022883506 hasAuthorship W2022883506A5082294371 @default.
- W2022883506 hasAuthorship W2022883506A5089305017 @default.
- W2022883506 hasConcept C104317684 @default.
- W2022883506 hasConcept C105580179 @default.
- W2022883506 hasConcept C150194340 @default.
- W2022883506 hasConcept C153911025 @default.
- W2022883506 hasConcept C159110408 @default.
- W2022883506 hasConcept C194583182 @default.
- W2022883506 hasConcept C22667442 @default.
- W2022883506 hasConcept C2775944032 @default.
- W2022883506 hasConcept C2781121885 @default.
- W2022883506 hasConcept C49453240 @default.
- W2022883506 hasConcept C53345823 @default.
- W2022883506 hasConcept C54355233 @default.
- W2022883506 hasConcept C54458228 @default.
- W2022883506 hasConcept C64943373 @default.
- W2022883506 hasConcept C67705224 @default.
- W2022883506 hasConcept C71924100 @default.
- W2022883506 hasConcept C86803240 @default.
- W2022883506 hasConcept C89604277 @default.
- W2022883506 hasConceptScore W2022883506C104317684 @default.
- W2022883506 hasConceptScore W2022883506C105580179 @default.
- W2022883506 hasConceptScore W2022883506C150194340 @default.
- W2022883506 hasConceptScore W2022883506C153911025 @default.
- W2022883506 hasConceptScore W2022883506C159110408 @default.
- W2022883506 hasConceptScore W2022883506C194583182 @default.
- W2022883506 hasConceptScore W2022883506C22667442 @default.
- W2022883506 hasConceptScore W2022883506C2775944032 @default.
- W2022883506 hasConceptScore W2022883506C2781121885 @default.
- W2022883506 hasConceptScore W2022883506C49453240 @default.
- W2022883506 hasConceptScore W2022883506C53345823 @default.
- W2022883506 hasConceptScore W2022883506C54355233 @default.
- W2022883506 hasConceptScore W2022883506C54458228 @default.
- W2022883506 hasConceptScore W2022883506C64943373 @default.
- W2022883506 hasConceptScore W2022883506C67705224 @default.
- W2022883506 hasConceptScore W2022883506C71924100 @default.
- W2022883506 hasConceptScore W2022883506C86803240 @default.
- W2022883506 hasConceptScore W2022883506C89604277 @default.
- W2022883506 hasIssue "12" @default.
- W2022883506 hasLocation W20228835061 @default.
- W2022883506 hasOpenAccess W2022883506 @default.
- W2022883506 hasPrimaryLocation W20228835061 @default.
- W2022883506 hasRelatedWork W1986662039 @default.
- W2022883506 hasRelatedWork W1995847322 @default.
- W2022883506 hasRelatedWork W2026771976 @default.
- W2022883506 hasRelatedWork W2028299201 @default.
- W2022883506 hasRelatedWork W2035900979 @default.
- W2022883506 hasRelatedWork W2092819668 @default.
- W2022883506 hasRelatedWork W2092849069 @default.
- W2022883506 hasRelatedWork W2162618419 @default.
- W2022883506 hasRelatedWork W2888038002 @default.
- W2022883506 hasRelatedWork W4205813338 @default.
- W2022883506 hasVolume "4" @default.
- W2022883506 isParatext "false" @default.
- W2022883506 isRetracted "false" @default.
- W2022883506 magId "2022883506" @default.
- W2022883506 workType "article" @default.