FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022885997> ?p ?o ?g. }

• W2022885997 endingPage "667" @default.
• W2022885997 startingPage "663" @default.
• W2022885997 abstract "The therapeutic efficacy of multipotent mesenchymal stromal cells (MSCs) is attributed to particular MSC-derived cytokines and growth factors. As MSCs are applied locally to target organs or home there after systemic administration, they experience diverse microenvironments that are biochemically and biophysically distinct. Here we use well-defined in vitro conditions to study the impact of substrate elasticity on MSC-derived trophic factors. By varying hydrogel compliance, the elasticity of brain and muscle tissue was mimicked. We screened >90 secreted factors at the protein level, finding a diverse elasticity-dependent expression pattern. In particular, IL-8 was up-regulated as much as 90-fold in MSCs cultured for 2 days on hard substrates, whereas levels were consistently low on soft substrates. In summary, we show substrate elasticity directly affects MSC paracrine expression, a relevant finding for therapies administering MSCs in vivo." @default.
• W2022885997 created "2016-06-24" @default.
• W2022885997 creator A5004592563 @default.
• W2022885997 creator A5015920322 @default.
• W2022885997 creator A5026849709 @default.
• W2022885997 creator A5047273756 @default.
• W2022885997 date "2009-11-01" @default.
• W2022885997 modified "2023-09-24" @default.
• W2022885997 title "Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs)" @default.
• W2022885997 cites W1965953554 @default.
• W2022885997 cites W1974207011 @default.
• W2022885997 cites W1978811179 @default.
• W2022885997 cites W1979043688 @default.
• W2022885997 cites W1983891090 @default.
• W2022885997 cites W1989560466 @default.
• W2022885997 cites W1991350431 @default.
• W2022885997 cites W2001811125 @default.
• W2022885997 cites W2004535645 @default.
• W2022885997 cites W2010193681 @default.
• W2022885997 cites W2013765882 @default.
• W2022885997 cites W2016662872 @default.
• W2022885997 cites W2032334748 @default.
• W2022885997 cites W2043058475 @default.
• W2022885997 cites W2049387285 @default.
• W2022885997 cites W2054095354 @default.
• W2022885997 cites W2057022448 @default.
• W2022885997 cites W2062932351 @default.
• W2022885997 cites W2079010145 @default.
• W2022885997 cites W2080264344 @default.
• W2022885997 cites W2095301611 @default.
• W2022885997 cites W2097149179 @default.
• W2022885997 cites W2098734814 @default.
• W2022885997 cites W2115444861 @default.
• W2022885997 cites W2116500923 @default.
• W2022885997 cites W2134208433 @default.
• W2022885997 cites W2139234903 @default.
• W2022885997 cites W2144023435 @default.
• W2022885997 cites W2154935039 @default.
• W2022885997 cites W2167243609 @default.
• W2022885997 cites W2172503413 @default.
• W2022885997 cites W82442207 @default.
• W2022885997 doi "https://doi.org/10.1016/j.bbrc.2009.09.051" @default.
• W2022885997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19766096" @default.
• W2022885997 hasPublicationYear "2009" @default.
• W2022885997 type Work @default.
• W2022885997 sameAs 2022885997 @default.
• W2022885997 citedByCount "80" @default.
• W2022885997 countsByYear W20228859972012 @default.
• W2022885997 countsByYear W20228859972013 @default.
• W2022885997 countsByYear W20228859972014 @default.
• W2022885997 countsByYear W20228859972015 @default.
• W2022885997 countsByYear W20228859972016 @default.
• W2022885997 countsByYear W20228859972017 @default.
• W2022885997 countsByYear W20228859972018 @default.
• W2022885997 countsByYear W20228859972019 @default.
• W2022885997 countsByYear W20228859972020 @default.
• W2022885997 countsByYear W20228859972021 @default.
• W2022885997 countsByYear W20228859972022 @default.
• W2022885997 countsByYear W20228859972023 @default.
• W2022885997 crossrefType "journal-article" @default.
• W2022885997 hasAuthorship W2022885997A5004592563 @default.
• W2022885997 hasAuthorship W2022885997A5015920322 @default.
• W2022885997 hasAuthorship W2022885997A5026849709 @default.
• W2022885997 hasAuthorship W2022885997A5047273756 @default.
• W2022885997 hasConcept C121854251 @default.
• W2022885997 hasConcept C150903083 @default.
• W2022885997 hasConcept C159985019 @default.
• W2022885997 hasConcept C16930146 @default.
• W2022885997 hasConcept C170493617 @default.
• W2022885997 hasConcept C185592680 @default.
• W2022885997 hasConcept C192562407 @default.
• W2022885997 hasConcept C198826908 @default.
• W2022885997 hasConcept C202751555 @default.
• W2022885997 hasConcept C203014093 @default.
• W2022885997 hasConcept C207001950 @default.
• W2022885997 hasConcept C2780007613 @default.
• W2022885997 hasConcept C502942594 @default.
• W2022885997 hasConcept C55493867 @default.
• W2022885997 hasConcept C7876069 @default.
• W2022885997 hasConcept C86803240 @default.
• W2022885997 hasConcept C95444343 @default.
• W2022885997 hasConceptScore W2022885997C121854251 @default.
• W2022885997 hasConceptScore W2022885997C150903083 @default.
• W2022885997 hasConceptScore W2022885997C159985019 @default.
• W2022885997 hasConceptScore W2022885997C16930146 @default.
• W2022885997 hasConceptScore W2022885997C170493617 @default.
• W2022885997 hasConceptScore W2022885997C185592680 @default.
• W2022885997 hasConceptScore W2022885997C192562407 @default.
• W2022885997 hasConceptScore W2022885997C198826908 @default.
• W2022885997 hasConceptScore W2022885997C202751555 @default.
• W2022885997 hasConceptScore W2022885997C203014093 @default.
• W2022885997 hasConceptScore W2022885997C207001950 @default.
• W2022885997 hasConceptScore W2022885997C2780007613 @default.
• W2022885997 hasConceptScore W2022885997C502942594 @default.
• W2022885997 hasConceptScore W2022885997C55493867 @default.
• W2022885997 hasConceptScore W2022885997C7876069 @default.
• W2022885997 hasConceptScore W2022885997C86803240 @default.
• W2022885997 hasConceptScore W2022885997C95444343 @default.

• next