FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022888479> ?p ?o ?g. }

• W2022888479 endingPage "1204" @default.
• W2022888479 startingPage "1199" @default.
• W2022888479 abstract "N-methyl-D-aspartate glutamate receptor (NMDA-R) antagonists produce schizophrenia-like positive and negative symptoms in healthy human subjects. Preclinical research suggests that NMDA-R antagonists interfere with the function of gamma-aminobutyric acid (GABA) neurons and alter the brain oscillations. These changes have been hypothesized to contribute to psychosis. In this investigation, we evaluated the hypothesis that the NMDA-R antagonist ketamine produces alterations in cortical functional connectivity during rest that are related to symptoms. We administered ketamine to a primary sample of 22 subjects and to an additional, partially overlapping, sample of 12 subjects. Symptoms before and after the experimental session were rated with the Positive and Negative Syndrome Scale (PANSS). In the primary sample, functional connectivity was measured via functional magnetic resonance imaging almost immediately after infusion began. In the additional sample, this assessment was repeated after 45 min of continuous ketamine infusion. Global, enhanced functional connectivity was observed at both timepoints, and this hyperconnectivity was related to symptoms in a region-specific manner. This study supports the hypothesis that pathological increases in resting brain functional connectivity contribute to the emergence of positive and negative symptoms associated with schizophrenia." @default.
• W2022888479 created "2016-06-24" @default.
• W2022888479 creator A5003407293 @default.
• W2022888479 creator A5016331294 @default.
• W2022888479 creator A5025902845 @default.
• W2022888479 creator A5037842456 @default.
• W2022888479 creator A5049975680 @default.
• W2022888479 creator A5052366236 @default.
• W2022888479 creator A5060512263 @default.
• W2022888479 creator A5067321338 @default.
• W2022888479 creator A5071039477 @default.
• W2022888479 creator A5080201746 @default.
• W2022888479 creator A5081806198 @default.
• W2022888479 creator A5081837367 @default.
• W2022888479 creator A5088958906 @default.
• W2022888479 date "2013-01-22" @default.
• W2022888479 modified "2023-10-17" @default.
• W2022888479 title "Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans" @default.
• W2022888479 cites W15515072 @default.
• W2022888479 cites W1914381346 @default.
• W2022888479 cites W1970448316 @default.
• W2022888479 cites W1978230214 @default.
• W2022888479 cites W1978660262 @default.
• W2022888479 cites W1979283977 @default.
• W2022888479 cites W1980921457 @default.
• W2022888479 cites W1982706444 @default.
• W2022888479 cites W1987285132 @default.
• W2022888479 cites W1987323424 @default.
• W2022888479 cites W1991661467 @default.
• W2022888479 cites W1994366727 @default.
• W2022888479 cites W1995221679 @default.
• W2022888479 cites W1997935178 @default.
• W2022888479 cites W2015592587 @default.
• W2022888479 cites W2018646758 @default.
• W2022888479 cites W2018699045 @default.
• W2022888479 cites W2020055733 @default.
• W2022888479 cites W2028884770 @default.
• W2022888479 cites W2033433729 @default.
• W2022888479 cites W2036802268 @default.
• W2022888479 cites W2038239475 @default.
• W2022888479 cites W2038577949 @default.
• W2022888479 cites W2046037125 @default.
• W2022888479 cites W2059957672 @default.
• W2022888479 cites W2061084307 @default.
• W2022888479 cites W2061506085 @default.
• W2022888479 cites W2061960110 @default.
• W2022888479 cites W2062104945 @default.
• W2022888479 cites W2064678154 @default.
• W2022888479 cites W2071199266 @default.
• W2022888479 cites W2071881327 @default.
• W2022888479 cites W2072471087 @default.
• W2022888479 cites W2078297889 @default.
• W2022888479 cites W2088811157 @default.
• W2022888479 cites W2089244139 @default.
• W2022888479 cites W2092036317 @default.
• W2022888479 cites W2093795230 @default.
• W2022888479 cites W2099360322 @default.
• W2022888479 cites W2099921986 @default.
• W2022888479 cites W2101356730 @default.
• W2022888479 cites W2117140276 @default.
• W2022888479 cites W2126349398 @default.
• W2022888479 cites W2133462240 @default.
• W2022888479 cites W2140506009 @default.
• W2022888479 cites W2141857827 @default.
• W2022888479 cites W2146434369 @default.
• W2022888479 cites W2150857753 @default.
• W2022888479 cites W2156222687 @default.
• W2022888479 cites W2157629216 @default.
• W2022888479 cites W2159694863 @default.
• W2022888479 cites W3018310297 @default.
• W2022888479 cites W4212930680 @default.
• W2022888479 cites W4235770099 @default.
• W2022888479 cites W4254734404 @default.
• W2022888479 cites W4849013 @default.
• W2022888479 doi "https://doi.org/10.1038/mp.2012.194" @default.
• W2022888479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3646075" @default.
• W2022888479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23337947" @default.
• W2022888479 hasPublicationYear "2013" @default.
• W2022888479 type Work @default.
• W2022888479 sameAs 2022888479 @default.
• W2022888479 citedByCount "193" @default.
• W2022888479 countsByYear W20228884792013 @default.
• W2022888479 countsByYear W20228884792014 @default.
• W2022888479 countsByYear W20228884792015 @default.
• W2022888479 countsByYear W20228884792016 @default.
• W2022888479 countsByYear W20228884792017 @default.
• W2022888479 countsByYear W20228884792018 @default.
• W2022888479 countsByYear W20228884792019 @default.
• W2022888479 countsByYear W20228884792020 @default.
• W2022888479 countsByYear W20228884792021 @default.
• W2022888479 countsByYear W20228884792022 @default.
• W2022888479 countsByYear W20228884792023 @default.
• W2022888479 crossrefType "journal-article" @default.
• W2022888479 hasAuthorship W2022888479A5003407293 @default.
• W2022888479 hasAuthorship W2022888479A5016331294 @default.
• W2022888479 hasAuthorship W2022888479A5025902845 @default.
• W2022888479 hasAuthorship W2022888479A5037842456 @default.
• W2022888479 hasAuthorship W2022888479A5049975680 @default.

• next